Cardinals vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for June 27

Odds updated as of 8:12 a.m.

The MLB slate on Friday includes the St. Louis Cardinals facing the Cleveland Guardians.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cardinals vs Guardians Game Info

• St. Louis Cardinals (44-38) vs. Cleveland Guardians (40-39)
• Date: Friday, June 27, 2025
• Time: 7:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: Apple TV+

Cardinals vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-130) | CLE: (+110)
• Spread: STL: -1.5 (+130) | CLE: +1.5 (-156)
• Total: 8.5 -- Over: (-100) | Under: (-122)

Cardinals vs Guardians Probable Starting Pitchers

Probable Pitchers: Sonny Gray (Cardinals) - 7-2, 3.72 ERA vs Luis Ortiz (Guardians) - 4-8, 4.30 ERA

The Cardinals will look to Sonny Gray (7-2) against the Guardians and Luis Ortiz (4-8). Gray's team is 9-6-0 against the spread this season in his starts. Gray's team has been victorious in 88.9% of the games he's started as the moneyline favorite with a record of 8-1. The Guardians are 6-9-0 against the spread when Ortiz starts. The Guardians have a 3-5 record in Ortiz's eight starts this season when they were the underdog on the moneyline.

Cardinals vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (58.5%)

Cardinals vs Guardians Moneyline

• Cleveland is a +110 underdog on the moneyline, while St. Louis is a -130 favorite on the road.

Cardinals vs Guardians Spread

• The Guardians are at +1.5 on the runline against the Cardinals. The Guardians are -156 to cover the spread, and the Cardinals are +130.

Cardinals vs Guardians Over/Under

• A total of 8.5 runs has been set for the Cardinals-Guardians game on June 27, with the over available at -100 and the under at -122.

Bet on St. Louis Cardinals vs. Cleveland Guardians on FanDuel today!

Cardinals vs Guardians Betting Trends

• The Cardinals have come away with 19 wins in the 35 contests they have been listed as the favorites in this season.
• This season St. Louis has been victorious 13 times in 19 chances when named as a favorite of at least -130 on the moneyline.
• The Cardinals' games have gone over the total in 43 of their 82 opportunities.
• In 82 games with a line this season, the Cardinals have a mark of 44-38-0 against the spread.
• The Guardians have a 21-27 record in games they were the underdog on the moneyline (winning 43.8% of those games).
• Cleveland is 9-15 (winning only 37.5% of its games) when it has played as a moneyline underdog of +110 or longer.
• The Guardians have played in 77 games with a set over/under, and have combined with opponents to go over the total 33 times (33-41-3).
• The Guardians have put together a 38-39-0 record against the spread this season (covering 49.4% of the time).

Cardinals Player Leaders

• Nolan Arenado is batting .242 with 11 doubles, a triple, 10 home runs and 24 walks. He has an on-base percentage of .305 while slugging .391.
• Among qualifying hitters in MLB, his batting average ranks 116th, his on-base percentage ranks 123rd, and he is 115th in slugging.
• Brendan Donovan is slashing .301/.368/.426 this season and leads the Cardinals with an OPS of .793.
• His batting average is 13th among qualified players, his on-base percentage 24th, and his slugging percentage 78th.
• Lars Nootbaar has collected 67 base hits, an OBP of .337 and a slugging percentage of .388 this season.
• Nootbaar brings a six-game hitting streak into this matchup. In his last 10 games he is batting .184 with a double, three home runs, six walks and seven RBIs.
• Masyn Winn has been key for St. Louis with 68 hits, an OBP of .323 plus a slugging percentage of .389.
• Winn has safely hit in three straight games. During his last five outings he is batting .278 with a double, a home run, a walk and four RBIs.

Guardians Player Leaders

• Jose Ramirez has accumulated an on-base percentage of .378, a slugging percentage of .514, and has 92 hits, all club-bests for the Guardians (while batting .317).
• He is sixth in batting average, 17th in on-base percentage and 16th in slugging percentage among all qualifying hitters in the majors.
• Steven Kwan is batting .306 with 18 doubles, six home runs and 28 walks. He's slugging .429 with an on-base percentage of .370.
• He is currently 11th in batting average, 23rd in on-base percentage and 74th in slugging percentage among all qualifying batters.
• Carlos Santana is batting .234 with six doubles, nine home runs and 35 walks.
• Kyle Manzardo has 11 doubles, two triples, 12 home runs and 25 walks while hitting .222.

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