Brewers vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for May 21

Odds updated as of 12:15 p.m.

The Milwaukee Brewers are among the MLB teams in action on Wednesday, up against the Baltimore Orioles.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Brewers vs Orioles Game Info

• Milwaukee Brewers (24-25) vs. Baltimore Orioles (15-32)
• Date: Wednesday, May 21, 2025
• Time: 1:10 p.m. ET
• Venue: American Family Field -- Milwaukee, Wisconsin
• Coverage: MLB Network, FDSWI, and MASN2

Brewers vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-122) | BAL: (+104)
• Spread: MIL: -1.5 (+160) | BAL: +1.5 (-194)
• Total: 8 -- Over: (-112) | Under: (-108)

Brewers vs Orioles Probable Starting Pitchers

Probable Pitchers: Chad Patrick (Brewers) - 2-4, 3.35 ERA vs Tomoyuki Sugano (Orioles) - 4-3, 3.08 ERA

The probable pitchers are Chad Patrick (2-4) for the Brewers and Tomoyuki Sugano (4-3) for the Orioles. Patrick and his team are 4-4-0 ATS this season when he starts. Patrick's team is 3-2 this season when he starts and they are the moneyline favorite. The Orioles have a 4-5-0 record against the spread in Sugano's starts. The Orioles have a 2-1 record in Sugano's three starts this season when they were the underdog on the moneyline.

Brewers vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (51.2%)

Brewers vs Orioles Moneyline

• Looking at the moneyline for Orioles-Brewers, Baltimore is the underdog at +104, and Milwaukee is -122 playing at home.

Brewers vs Orioles Spread

• The Brewers are favored by 1.5 runs at home versus the Orioles. The Brewers are +160 to cover the spread, while the Orioles are -194.

Brewers vs Orioles Over/Under

• The Brewers-Orioles contest on May 21 has been given an over/under of 8 runs. The over is set at -112 and the under at -108.

Bet on Milwaukee Brewers vs. Baltimore Orioles on FanDuel today!

Brewers vs Orioles Betting Trends

• The Brewers have been chosen as favorites in 24 games this year and have walked away with the win 17 times (70.8%) in those games.
• This season Milwaukee has come away with a win 13 times in 17 chances when named as a favorite of at least -122 on the moneyline.
• The Brewers' games have gone over the total in 18 of their 48 opportunities.
• In 48 games with a line this season, the Brewers have a mark of 26-22-0 against the spread.
• The Orioles have gone 6-13 in games they were the underdog on the moneyline (winning 31.6% of those games).
• Baltimore has a 3-9 record (winning only 25% of its games) when it has played as a moneyline underdog of +104 or longer.
• The Orioles have played in 47 games with a set over/under, and have combined with opponents to go over the total 23 times (23-22-2).
• The Orioles have gone 14-33-0 ATS this season.

Brewers Player Leaders

• Brice Turang leads Milwaukee in slugging percentage (.390) thanks to eight extra-base hits. He has a .297 batting average and an on-base percentage of .372.
• Among all qualifying hitters in baseball, his batting average ranks 21st, his on-base percentage ranks 32nd, and he is 108th in slugging.
• Turang has recorded at least one hit in two straight games. In his last five games he is hitting .350 with a double, a home run, two walks and three RBIs.
• William Contreras is batting .255 with six doubles, four home runs and 31 walks, while slugging .366 with an on-base percentage of .373.
• He ranks 85th in batting average, 30th in on-base percentage and 124th in slugging among qualified batters.
• Sal Frelick has 44 hits this season and has a slash line of .282/.360/.410.
• Frelick has logged a hit or more in three games in a row. In his last five games he is batting .375 with a triple, a home run, two walks and four RBIs.
• Jackson Chourio has been key for Milwaukee with 49 hits, an OBP of .257 plus a slugging percentage of .415.

Orioles Player Leaders

• Cedric Mullins has eight doubles, 10 home runs and 22 walks while hitting .230. He's slugging .466 with an on-base percentage of .330.
• He is 119th in batting average, 79th in on-base percentage and 45th in slugging percentage among all qualifying hitters in the big leagues.
• Mullins hopes to build on a three-game hitting streak in this matchup. In his last five games he is hitting .211 with a double, two home runs, two walks and five RBIs.
• Ryan O'Hearn has 37 hits with a .385 OBP to lead his team in both. He has a batting average of .289 while slugging .492.
• He is currently 31st in batting average, 16th in on-base percentage and 32nd in slugging percentage among all qualified hitters.
• Jackson Holliday is hitting .272 with four doubles, two triples, six home runs and 10 walks.
• Gunnar Henderson's .457 slugging percentage paces his team.

Brewers vs Orioles Head to Head

• 5/20/2025: 5-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/19/2025: 5-4 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/14/2024: 6-4 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 4/13/2024: 11-5 MIL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/12/2024: 11-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/8/2023: 6-3 BAL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/7/2023: 10-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/6/2023: 4-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/13/2022: 4-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 4/12/2022: 5-4 MIL (Favorite: Brewers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -156, Underdog Moneyline: +132)

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