Brewers vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for May 21

Odds updated as of 2:11 a.m.

The Milwaukee Brewers versus the Baltimore Orioles is on the MLB schedule for Wednesday.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Brewers vs Orioles Game Info

• Milwaukee Brewers (24-25) vs. Baltimore Orioles (15-32)
• Date: Wednesday, May 21, 2025
• Time: 1:10 p.m. ET
• Venue: American Family Field -- Milwaukee, Wisconsin
• Coverage: MLB Network, FDSWI, and MASN2

Brewers vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-126) | BAL: (+108)
• Spread: MIL: -1.5 (+162) | BAL: +1.5 (-194)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Brewers vs Orioles Probable Starting Pitchers

Probable Pitchers: Chad Patrick (Brewers) - 2-4, 3.35 ERA vs Tomoyuki Sugano (Orioles) - 4-3, 3.08 ERA

The Brewers will give the ball to Chad Patrick (2-4, 3.35 ERA), who is eyeing win No. 3 on the season, and the Orioles will turn to Tomoyuki Sugano (4-3, 3.08 ERA). When Patrick starts, his team is 4-4-0 against the spread this season. Patrick's team has been victorious in 60% of the games he's started as the moneyline favorite with a record of 3-2. The Orioles have a 4-5-0 ATS record in Sugano's nine starts that had a set spread. The Orioles have a 2-1 record in Sugano's three starts this season when they were the underdog on the moneyline.

Brewers vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (51.3%)

Brewers vs Orioles Moneyline

• Looking at the moneyline for Orioles-Brewers, Baltimore is the underdog at +108, and Milwaukee is -126 playing at home.

Brewers vs Orioles Spread

• The Brewers are hosting the Orioles and are favored by 1.5 runs on the spread. The Brewers are +162 to cover the runline, with the Orioles being -194.

Brewers vs Orioles Over/Under

• The over/under for the Brewers versus Orioles game on May 21 has been set at 8.5, with -105 odds on the over and -115 odds on the under.

Bet on Milwaukee Brewers vs. Baltimore Orioles on FanDuel today!

Brewers vs Orioles Betting Trends

• The Brewers have won in 17, or 70.8%, of the 24 contests they have been named as odds-on favorites in this year.
• Milwaukee has a record of 9-3 in contests when oddsmakers favor them by -126 or more on the moneyline.
• The Brewers and their opponents have gone over in 18 of their 48 games with a total set by sportsbooks this season.
• The Brewers are 26-22-0 against the spread in their 48 games that had a posted line this season.
• The Orioles have won six of the 19 games they were the underdog on the moneyline this season (31.6%).
• When it has played as a moneyline underdog with odds of +108 or longer, Baltimore has a record of 1-7 (12.5%).
• The Orioles have had an over/under set by bookmakers 47 times, and have combined with opponents to go over the total in 23 of those games (23-22-2).
• The Orioles have covered just 29.8% of their games this season, going 14-33-0 against the spread.

Brewers Player Leaders

• Brice Turang has an OPS of .762, fueled by an OBP of .372 and a team-best slugging percentage of .390 this season. He has a .297 batting average.
• Among all qualifying hitters, he ranks 22nd in batting average, his on-base percentage ranks 32nd, and he is 107th in slugging.
• Turang hopes to build on a two-game hitting streak in this matchup. In his last five games he is batting .350 with a double, a home run, two walks and three RBIs.
• William Contreras is batting .255 with six doubles, four home runs and 31 walks. He's slugging .366 with an on-base percentage of .373.
• He is 84th in batting average, 30th in on-base percentage and 124th in slugging among qualifying hitters.
• Sal Frelick is batting .282 with a .410 slugging percentage and 14 RBI this year.
• Frelick enters this game with three games in a row with at least one hit. In his last five games he is hitting .375 with a triple, a home run, two walks and four RBIs.
• Rhys Hoskins leads Milwaukee with 43 hits and an OBP of .402 this season.
• Hoskins has safely hit in four games in a row. During his last five outings he is batting .333 with two doubles, a home run, four walks and two RBIs.

Orioles Player Leaders

• Cedric Mullins is hitting .230 with eight doubles, 10 home runs and 22 walks. He's slugging .466 with an on-base percentage of .330.
• Including all the qualifying players in MLB, he is 118th in batting average, 81st in on-base percentage and 44th in slugging percentage.
• Mullins hopes to build on a three-game hitting streak in this matchup. During his last five outings he is batting .211 with a double, two home runs, two walks and five RBIs.
• Ryan O'Hearn paces his team with 37 hits and a .385 OBP. He has a batting average of .289 while slugging .492.
• Including all qualified hitters, he ranks 31st in batting average, 16th in on-base percentage and 31st in slugging percentage.
• Jackson Holliday is hitting .272 with four doubles, two triples, six home runs and 10 walks.
• Gunnar Henderson is slugging .457 to pace his team.

Brewers vs Orioles Head to Head

• 5/20/2025: 5-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/19/2025: 5-4 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/14/2024: 6-4 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 4/13/2024: 11-5 MIL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/12/2024: 11-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/8/2023: 6-3 BAL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/7/2023: 10-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/6/2023: 4-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/13/2022: 4-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 4/12/2022: 5-4 MIL (Favorite: Brewers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -156, Underdog Moneyline: +132)

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