Best College Football Games Week 4: Predictions, Odds, Picks, Best Bets

Ranked squads are on the Week 4 college football schedule for 18 games, including the No. 1 Texas Longhorns playing the No. 14 Tennessee Volunteers.

Trying to find an edge in college football? We break down the betting odds for each of the big games below.

For additional insights, check out the latest college football betting picks from FanDuel Research's staff of writers.

Indiana vs. Northwestern

• Matchup: Northwestern Wildcats at No. 5 Indiana Hoosiers
• Projected Favorite: Indiana (86.26% win probability)
• Spread: Indiana (-20.5)
• Total: 49.5
• Time: 8 p.m. ET
• Date: Sept. 25
• TV Channel: FOX

Bet on Indiana vs. Northwestern with FanDuel Sportsbook.

Ohio State vs. Illinois

• Matchup: Illinois Fighting Illini at No. 7 Ohio State Buckeyes
• Projected Favorite: Ohio State (91.18% win probability)
• Spread: Ohio State (-26.5)
• Total: 54.5
• Time: 12 p.m. ET
• Date: Sept. 26
• TV Channel: FOX

Bet on Ohio State vs. Illinois with FanDuel Sportsbook.

Tennessee vs. Texas

• Matchup: No. 1 Texas Longhorns at No. 14 Tennessee Volunteers
• Projected Favorite: Texas (63.62% win probability)
• Spread: Texas (-5.5)
• Total: 54.5
• Time: 12 p.m. ET
• Date: Sept. 26
• TV Channel: ABC

Bet on Tennessee vs. Texas with FanDuel Sportsbook.

Louisville vs. Wake Forest

• Matchup: Wake Forest Demon Deacons at No. 16 Louisville Cardinals
• Projected Favorite: Louisville (79.03% win probability)
• Spread: Louisville (-12.5)
• Total: 57.5
• Time: 12 p.m. ET
• Date: Sept. 26
• TV Channel: ESPN

Bet on Louisville vs. Wake Forest with FanDuel Sportsbook.

Texas Tech vs. Sam Houston

• Matchup: Sam Houston Bearkats at No. 11 Texas Tech Red Raiders
• Projected Favorite: Texas Tech (97.69% win probability)
• Spread: Texas Tech (-34.5)
• Total: 56.5
• Time: 12 p.m. ET
• Date: Sept. 26
• TV Channel: TNT

Bet on Texas Tech vs. Sam Houston with FanDuel Sportsbook.

Purdue vs. Notre Dame

• Matchup: No. 3 Notre Dame Fighting Irish at Purdue Boilermakers
• Projected Favorite: Notre Dame (97.09% win probability)
• Spread: Notre Dame (-27.5)
• Total: 57.5
• Time: 2 p.m. ET
• Date: Sept. 26
• TV Channel: Peacock

Bet on Purdue vs. Notre Dame with FanDuel Sportsbook.

Michigan vs. Iowa

• Matchup: No. 17 Iowa Hawkeyes at No. 18 Michigan Wolverines
• Projected Favorite: Michigan (58.94% win probability)
• Spread: Michigan (-5.5)
• Total: 40.5
• Time: 3:30 p.m. ET
• Date: Sept. 26
• TV Channel: CBS

Bet on Michigan vs. Iowa with FanDuel Sportsbook.

Georgia vs. Oklahoma

• Matchup: Oklahoma Sooners at No. 2 Georgia Bulldogs
• Projected Favorite: Georgia (81.51% win probability)
• Spread: Georgia (-13.5)
• Total: 44.5
• Time: 3:30 p.m. ET
• Date: Sept. 26
• TV Channel: ESPN

Bet on Georgia vs. Oklahoma with FanDuel Sportsbook.

Florida vs. Ole Miss

• Matchup: No. 4 Ole Miss Rebels at No. 21 Florida Gators
• Projected Favorite: Ole Miss (50.16% win probability)
• Spread: Florida (-3.5)
• Total: 59.5
• Time: 3:30 p.m. ET
• Date: Sept. 26
• TV Channel: ABC

Bet on Florida vs. Ole Miss with FanDuel Sportsbook.

Iowa State vs. Utah

• Matchup: No. 15 Utah Utes at Iowa State Cyclones
• Projected Favorite: Utah (73.67% win probability)
• Spread: Utah (-7.5)
• Total: 46.5
• Time: 3:30 p.m. ET
• Date: Sept. 26
• TV Channel: FOX

Bet on Iowa State vs. Utah with FanDuel Sportsbook.

Georgia Southern vs. Houston

• Matchup: No. 25 Houston Cougars at Georgia Southern Eagles
• Projected Favorite: Houston (83.04% win probability)
• Spread: Houston (-17.5)
• Total: 56.5
• Time: 4 p.m. ET
• Date: Sept. 26
• TV Channel: ESPNU

Bet on Georgia Southern vs. Houston with FanDuel Sportsbook.

Penn State vs. Wisconsin

• Matchup: Wisconsin Badgers at No. 13 Penn State Nittany Lions
• Projected Favorite: Penn State (77.64% win probability)
• Spread: Penn State (-9.5)
• Total: 43.5
• Time: 5 p.m. ET
• Date: Sept. 26
• TV Channel: Peacock

Bet on Penn State vs. Wisconsin with FanDuel Sportsbook.

Miami (FL) vs. Central Michigan

• Matchup: Central Michigan Chippewas at No. 6 Miami Hurricanes
• Projected Favorite: Miami (FL) (98.71% win probability)
• Spread: Miami (FL) (-41.5)
• Total: 52.5
• Time: 6:30 p.m. ET
• Date: Sept. 26
• TV Channel: The CW

Bet on Miami (FL) vs. Central Michigan with FanDuel Sportsbook.

Alabama vs. South Carolina

• Matchup: South Carolina Gamecocks at No. 8 Alabama Crimson Tide
• Projected Favorite: Alabama (83.97% win probability)
• Spread: Alabama (-12.5)
• Total: 53.5
• Time: 7 p.m. ET
• Date: Sept. 26
• TV Channel: ESPN

Bet on Alabama vs. South Carolina with FanDuel Sportsbook.

LSU vs. Texas A&M

• Matchup: No. 23 Texas A&M Aggies at No. 10 LSU Tigers
• Projected Favorite: LSU (65.95% win probability)
• Spread: LSU (-8.5)
• Total: 52.5
• Time: 7:30 p.m. ET
• Date: Sept. 26
• TV Channel: ABC

Bet on LSU vs. Texas A&M with FanDuel Sportsbook.

USC vs. Oregon

• Matchup: No. 20 Oregon Ducks at No. 12 USC Trojans
• Projected Favorite: Oregon (54.75% win probability)
• Spread: Oregon (-3.5)
• Total: 60.5
• Time: 7:30 p.m. ET
• Date: Sept. 26
• TV Channel: NBC

Bet on USC vs. Oregon with FanDuel Sportsbook.

Mississippi State vs. Missouri

• Matchup: No. 19 Missouri Tigers at No. 24 Mississippi State Bulldogs
• Projected Favorite: Mississippi State (61.59% win probability)
• Spread: Mississippi State (-4.5)
• Total: 58.5
• Time: 7:45 p.m. ET
• Date: Sept. 26
• TV Channel: SEC Network

Bet on Mississippi State vs. Missouri with FanDuel Sportsbook.

SMU vs. Missouri State

• Matchup: Missouri State Bears at No. 22 SMU Mustangs
• Projected Favorite: SMU (97.39% win probability)
• Spread: SMU (-30.5)
• Total: 60.5
• Time: 9 p.m. ET
• Date: Sept. 26
• TV Channel: ACC Network

Bet on SMU vs. Missouri State with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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