Best College Football Games Week 4: Predictions, Odds, Picks, Best Bets

The No. 1 Texas Longhorns and the No. 14 Tennessee Volunteers take the field for one of 18 games on the college football slate in Week 4 that include a ranked team.

Here are the betting odds to break down ahead of Week 4 in college football.

For additional insights, check out the latest college football betting picks from FanDuel Research's staff of writers.

Indiana vs. Northwestern

• Matchup: Northwestern Wildcats at No. 5 Indiana Hoosiers
• Projected Favorite: Indiana (86.68% win probability)
• Spread: Indiana (-20.5)
• Total: 49.5
• Time: 8 p.m. ET
• Date: Sept. 25
• TV Channel: FOX

Bet on Indiana vs. Northwestern with FanDuel Sportsbook.

Ohio State vs. Illinois

• Matchup: Illinois Fighting Illini at No. 7 Ohio State Buckeyes
• Projected Favorite: Ohio State (90.58% win probability)
• Spread: Ohio State (-27.5)
• Total: 54.5
• Time: 12 p.m. ET
• Date: Sept. 26
• TV Channel: FOX

Bet on Ohio State vs. Illinois with FanDuel Sportsbook.

Tennessee vs. Texas

• Matchup: No. 1 Texas Longhorns at No. 14 Tennessee Volunteers
• Projected Favorite: Texas (60.88% win probability)
• Spread: Texas (-4.5)
• Total: 55.5
• Time: 12 p.m. ET
• Date: Sept. 26
• TV Channel: ABC

Bet on Tennessee vs. Texas with FanDuel Sportsbook.

Louisville vs. Wake Forest

• Matchup: Wake Forest Demon Deacons at No. 16 Louisville Cardinals
• Projected Favorite: Louisville (79.16% win probability)
• Spread: Louisville (-12.5)
• Total: 57.5
• Time: 12 p.m. ET
• Date: Sept. 26
• TV Channel: ESPN

Bet on Louisville vs. Wake Forest with FanDuel Sportsbook.

Texas Tech vs. Sam Houston

• Matchup: Sam Houston Bearkats at No. 11 Texas Tech Red Raiders
• Projected Favorite: Texas Tech (98.13% win probability)
• Spread: Texas Tech (-34.5)
• Total: 55.5
• Time: 12 p.m. ET
• Date: Sept. 26
• TV Channel: TNT

Bet on Texas Tech vs. Sam Houston with FanDuel Sportsbook.

Purdue vs. Notre Dame

• Matchup: No. 3 Notre Dame Fighting Irish at Purdue Boilermakers
• Projected Favorite: Notre Dame (96.13% win probability)
• Spread: Notre Dame (-27.5)
• Total: 58.5
• Time: 2 p.m. ET
• Date: Sept. 26
• TV Channel: Peacock

Bet on Purdue vs. Notre Dame with FanDuel Sportsbook.

Michigan vs. Iowa

• Matchup: No. 17 Iowa Hawkeyes at No. 18 Michigan Wolverines
• Projected Favorite: Michigan (59.22% win probability)
• Spread: Michigan (-5.5)
• Total: 38.5
• Time: 3:30 p.m. ET
• Date: Sept. 26
• TV Channel: CBS

Bet on Michigan vs. Iowa with FanDuel Sportsbook.

Georgia vs. Oklahoma

• Matchup: Oklahoma Sooners at No. 2 Georgia Bulldogs
• Projected Favorite: Georgia (80.53% win probability)
• Spread: Georgia (-13.5)
• Total: 44.5
• Time: 3:30 p.m. ET
• Date: Sept. 26
• TV Channel: ESPN

Bet on Georgia vs. Oklahoma with FanDuel Sportsbook.

Florida vs. Ole Miss

• Matchup: No. 4 Ole Miss Rebels at No. 21 Florida Gators
• Projected Favorite: Florida (50.85% win probability)
• Spread: Florida (-3.5)
• Total: 58.5
• Time: 3:30 p.m. ET
• Date: Sept. 26
• TV Channel: ABC

Bet on Florida vs. Ole Miss with FanDuel Sportsbook.

Iowa State vs. Utah

• Matchup: No. 15 Utah Utes at Iowa State Cyclones
• Projected Favorite: Utah (75.17% win probability)
• Spread: Utah (-8.5)
• Total: 48.5
• Time: 3:30 p.m. ET
• Date: Sept. 26
• TV Channel: FOX

Bet on Iowa State vs. Utah with FanDuel Sportsbook.

Georgia Southern vs. Houston

• Matchup: No. 25 Houston Cougars at Georgia Southern Eagles
• Projected Favorite: Houston (86.73% win probability)
• Spread: Houston (-18.5)
• Total: 56.5
• Time: 4 p.m. ET
• Date: Sept. 26
• TV Channel: ESPNU

Bet on Georgia Southern vs. Houston with FanDuel Sportsbook.

Penn State vs. Wisconsin

• Matchup: Wisconsin Badgers at No. 13 Penn State Nittany Lions
• Projected Favorite: Penn State (75.41% win probability)
• Spread: Penn State (-9.5)
• Total: 44.5
• Time: 5 p.m. ET
• Date: Sept. 26
• TV Channel: Peacock

Bet on Penn State vs. Wisconsin with FanDuel Sportsbook.

Miami (FL) vs. Central Michigan

• Matchup: Central Michigan Chippewas at No. 6 Miami Hurricanes
• Projected Favorite: Miami (FL) (98.68% win probability)
• Spread: Miami (FL) (-41.5)
• Total: 53.5
• Time: 6:30 p.m. ET
• Date: Sept. 26
• TV Channel: The CW

Bet on Miami (FL) vs. Central Michigan with FanDuel Sportsbook.

Alabama vs. South Carolina

• Matchup: South Carolina Gamecocks at No. 8 Alabama Crimson Tide
• Projected Favorite: Alabama (82.11% win probability)
• Spread: Alabama (-12.5)
• Total: 53.5
• Time: 7 p.m. ET
• Date: Sept. 26
• TV Channel: ESPN

Bet on Alabama vs. South Carolina with FanDuel Sportsbook.

LSU vs. Texas A&M

• Matchup: No. 23 Texas A&M Aggies at No. 10 LSU Tigers
• Projected Favorite: LSU (62.15% win probability)
• Spread: LSU (-8.5)
• Total: 51.5
• Time: 7:30 p.m. ET
• Date: Sept. 26
• TV Channel: ABC

Bet on LSU vs. Texas A&M with FanDuel Sportsbook.

USC vs. Oregon

• Matchup: No. 20 Oregon Ducks at No. 12 USC Trojans
• Projected Favorite: Oregon (51.57% win probability)
• Spread: Oregon (-3.5)
• Total: 62.5
• Time: 7:30 p.m. ET
• Date: Sept. 26
• TV Channel: NBC

Bet on USC vs. Oregon with FanDuel Sportsbook.

Mississippi State vs. Missouri

• Matchup: No. 19 Missouri Tigers at No. 24 Mississippi State Bulldogs
• Projected Favorite: Mississippi State (65.69% win probability)
• Spread: Mississippi State (-5.5)
• Total: 58.5
• Time: 7:45 p.m. ET
• Date: Sept. 26
• TV Channel: SEC Network

Bet on Mississippi State vs. Missouri with FanDuel Sportsbook.

SMU vs. Missouri State

• Matchup: Missouri State Bears at No. 22 SMU Mustangs
• Projected Favorite: SMU (96.56% win probability)
• Spread: SMU (-34.5)
• Total: 60.5
• Time: 9 p.m. ET
• Date: Sept. 26
• TV Channel: ACC Network

Bet on SMU vs. Missouri State with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!