Ohio State vs Illinois Prediction, Odds, Picks, Best Bets for Week 4 2026

Saturday's slate in college football includes a matchup between the Ohio State Buckeyes and the Illinois Fighting Illini.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Ohio State vs Illinois Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Ohio State: (-4545) | Illinois: (+1600)
• Spread: Ohio State: -27.5 (-105) | Illinois: +27.5 (-115)
• Total: 53.5 -- Over: (-115) | Under: (-105)

Ohio State vs Illinois Betting Trends

• Ohio State's record against the spread is 3-0-0.
• Ohio State is unbeaten ATS (2-0) as a 27.5-point favorite or greater this season.
• Two of Ohio State's three games have hit the over.
• Illinois has but one win versus the spread this year.
• All three Illinois games have gone over the point total this year.

Ohio State vs Illinois Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Buckeyes win (90.7%)

Ohio State vs Illinois Point Spread

Illinois is listed as an underdog by 27.5 points (-115 odds), and Ohio State, the favorite, is -105 to cover.

Ohio State vs Illinois Over/Under

An over/under of 53.5 has been set for Ohio State-Illinois on Sept. 26, with the over being -115 and the under -105.

Ohio State vs Illinois Moneyline

Ohio State is the favorite, -4545 on the moneyline, while Illinois is a +1600 underdog.

Ohio State vs. Illinois Points Insights

Ohio State vs. Illinois Game Info

• Game day: Saturday, September 26, 2026
• Game time: 12 p.m. ET
• TV channel: FOX
• Location: Columbus, Ohio
• Stadium: Ohio Stadium

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Check out even more in-depth Ohio State vs. Illinois analysis on FanDuel Research.