Ohio State vs Illinois Prediction, Odds, Picks, Best Bets for Week 4 2026

The Saturday schedule in college football includes a matchup between the Ohio State Buckeyes and the Illinois Fighting Illini.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Ohio State vs Illinois Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Ohio State: (-4545) | Illinois: (+1600)
• Spread: Ohio State: -27.5 (-105) | Illinois: +27.5 (-115)
• Total: 54.5 -- Over: (-105) | Under: (-115)

Ohio State vs Illinois Betting Trends

• Against the spread, Ohio State is 3-0-0 this year.
• Ohio State has covered every time (2-0) as a 27.5-point favorite or greater this season.
• Ohio State has had two games (out of three) go over the total this year.
• Illinois has one win against the spread this season.
• Illinois and its opponent have yet to not hit the over this year.

Ohio State vs Illinois Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Buckeyes win (90.6%)

Ohio State vs Illinois Point Spread

Ohio State is favored by 27.5 points versus Illinois. Ohio State is -105 to cover the spread, while Illinois is -115.

Ohio State vs Illinois Over/Under

The over/under for the Ohio State versus Illinois game on Sept. 26 has been set at 54.5, with -105 odds on the over and -115 odds on the under.

Ohio State vs Illinois Moneyline

Illinois is the underdog, +1600 on the moneyline, while Ohio State is a -4545 favorite.

Ohio State vs. Illinois Points Insights

Ohio State vs. Illinois Game Info

• Game day: Saturday, September 26, 2026
• Game time: 12 p.m. ET
• TV channel: FOX
• Location: Columbus, Ohio
• Stadium: Ohio Stadium

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Check out even more in-depth Ohio State vs. Illinois analysis on FanDuel Research.