Louisville vs Wake Forest Prediction, Odds, Picks, Best Bets for Week 4 2026

In college football action on Saturday, the Louisville Cardinals play the Wake Forest Demon Deacons.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

Louisville vs Wake Forest Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Louisville: (-521) | Wake Forest: (+385)
• Spread: Louisville: -12.5 (-110) | Wake Forest: +12.5 (-110)
• Total: 57.5 -- Over: (-112) | Under: (-108)

Louisville vs Wake Forest Betting Trends

• Louisville has covered the spread in every game this season.
• Louisville has yet to lose ATS (1-0) as a 12.5-point favorite or greater this season.
• Louisville and its opponent have not failed to hit the over in any game this season.
• Wake Forest has posted one win against the spread this season.
• Wake Forest is unbeaten ATS (1-0) as a 12.5-point underdog or greater this year.
• Wake Forest has played two games (out of three) which finished over the total this year.

Louisville vs Wake Forest Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (78.3%)

Louisville vs Wake Forest Point Spread

Louisville is favored by 12.5 points (-110 to cover) in this matchup. Wake Forest, the underdog, is -110.

Louisville vs Wake Forest Over/Under

The Louisville-Wake Forest matchup on Sept. 26 has been given an over/under of 57.5 points. The over is -112 and the under is -108.

Louisville vs Wake Forest Moneyline

Wake Forest is the underdog, +385 on the moneyline, while Louisville is a -521 favorite.

Louisville vs. Wake Forest Points Insights

Louisville vs. Wake Forest Game Info

• Game day: Saturday, September 26, 2026
• Game time: 12 p.m. ET
• TV channel: ESPN
• Location: Louisville, Kentucky
• Stadium: L&N Federal Credit Union Stadium

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Check out even more in-depth Louisville vs. Wake Forest analysis on FanDuel Research.