Louisville vs Wake Forest Prediction, Odds, Picks, Best Bets for Week 4 2026

Subscribe to our newsletter

The Louisville Cardinals versus the Wake Forest Demon Deacons is on the college football schedule for Saturday.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Louisville vs Wake Forest Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: Louisville: (-465) | Wake Forest: (+350)
Spread: Louisville: -12.5 (-106) | Wake Forest: +12.5 (-114)
Total: 57.5 -- Over: (-115) | Under: (-105)

Louisville's record against the spread is 3-0-0.
Louisville has covered every time (1-0) as a 12.5-point favorite or greater this year.
Louisville and its opponent have not failed to hit the over in any game this season.
Wake Forest has posted one win against the spread this year.
Wake Forest is unbeaten ATS (1-0) as a 12.5-point underdog or more this season.
A pair of Wake Forest three games in 2026 have gone over the point total.

All college football win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (79.2%)

Louisville is favored by 12.5 points against Wake Forest. Louisville is -106 to cover the spread, while Wake Forest is -114.

The over/under for the Louisville versus Wake Forest matchup on Sept. 26 has been set at 57.5, with -115 odds on the over and -105 odds on the under.

The moneyline numbers for Louisville vs. Wake Forest reveal Louisville as the favorite (-465) and Wake Forest as the underdog (+350).

	Point Scored (PG)	Points Scored CFB Rank	Points Allowed (PG)	Points Allowed CFB Rank	Average Total	Total Games
Louisville	46.0	14	28.3	103	56.8	3
Wake Forest	32.0	63	28.3	103	52.5	3

Check out even more in-depth Louisville vs. Wake Forest analysis on FanDuel Research.

Want more stories like this?