Pirates vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 24

Odds updated as of 12:11 p.m.

The Thursday slate in MLB includes a matchup between the Pittsburgh Pirates and the St. Louis Cardinals.

We've got you covered, in terms of the vital information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Pirates vs Cardinals Game Info

• Pittsburgh Pirates (80-78) vs. St. Louis Cardinals (77-81)
• Date: Thursday, September 24, 2026
• Time: 12:35 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and Cardinals.TV

Pirates vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-162) | STL: (+136)
• Spread: PIT: -1.5 (+152) | STL: +1.5 (-184)
• Total: 6.5 -- Over: (-138) | Under: (+112)

Pirates vs Cardinals Probable Starting Pitchers

Probable Pitchers: Paul Skenes (Pirates) - 10-11, 3.91 ERA vs Kyle Leahy (Cardinals) - 10-5, 3.65 ERA

The Pirates will give the nod to Paul Skenes (10-11, 3.91 ERA), who is eyeing win No. 11 on the season, and the Cardinals will turn to Kyle Leahy (10-5, 3.65 ERA). When Skenes starts, his team is 11-20-0 against the spread this season. Skenes' team is 12-13 this season when he starts and they are the moneyline favorite. The Cardinals are 13-14-0 ATS in Leahy's 27 starts that had a set spread. The Cardinals have a 6-10 record in Leahy's 16 starts this season when they were the underdog on the moneyline.

Pirates vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (64.5%)

Pirates vs Cardinals Moneyline

• Pittsburgh is a -162 favorite on the moneyline, while St. Louis is a +136 underdog on the road.

Pirates vs Cardinals Spread

• The Pirates are hosting the Cardinals and are favored by 1.5 runs (+152 to cover) on the runline. St. Louis is -184 to cover.

Pirates vs Cardinals Over/Under

• The Pirates-Cardinals game on Sept. 24 has been given an over/under of 6.5 runs. The over is set at -138 and the under at +112.

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Pirates vs Cardinals Betting Trends

• The Pirates have been victorious in 47, or 58%, of the 81 contests they have been chosen as favorites in this season.
• Pittsburgh has a record of 11-9 when favored by -162 or more this year.
• The Pirates and their opponents have gone over the total this season in 81 of their 156 opportunities.
• In 156 games with a line this season, the Pirates have a mark of 78-78-0 against the spread.
• The Cardinals have a 46-53 record in games they were listed as the moneyline underdog (winning 46.5% of those games).
• When it has played as a moneyline underdog with odds of +136 or longer, St. Louis has a 12-15 record (winning 44.4% of its games).
• The Cardinals have played in 154 games with a set over/under, and have combined with their opponents to go over the total 71 times (71-76-7).
• The Cardinals have put together an 82-72-0 record ATS this season.

Pirates Player Leaders

• Bryan Reynolds leads Pittsburgh with an OBP of .364 this season while batting .261 with 86 walks and 101 runs scored. He has a slugging percentage of .422.
• Among qualified hitters in baseball, he ranks 62nd in batting average, 20th in on-base percentage, and 71st in slugging.
• Brandon Lowe leads Pittsburgh in total hits (150) this season while batting .262 with 64 extra-base hits. He's slugging .494 with an on-base percentage of .331.
• Among all qualifying players, he is 56th in batting average, 68th in on-base percentage and 16th in slugging percentage.
• Nick Gonzales leads the Pirates with an OPS of .752. He has a slash line of .301/.364/.388 this season.
• Ryan O'Hearn has 18 home runs, 74 RBI and a batting average of .267 this season.
• O'Hearn takes a three-game hitting streak into this game. During his last five outings he is hitting .235 with two doubles, two walks and two RBIs.

Cardinals Player Leaders

• Alec Burleson has a .461 slugging percentage, which leads the Cardinals. He's batting .279 with an on-base percentage of .344.
• He ranks 25th in batting average, 49th in on-base percentage and 36th in slugging percentage among all qualified hitters in MLB.
• Jordan Walker has 162 hits to lead his team. He has a batting average of .273 while slugging .470 with an on-base percentage of .330.
• Including all qualifying players, he ranks 37th in batting average, 70th in on-base percentage and 30th in slugging percentage.
• Ivan Herrera has a team-best .357 on-base percentage.
• JJ Wetherholt is hitting .244 with 14 doubles, 17 home runs and 64 walks.

Pirates vs Cardinals Head to Head

• 9/23/2026: 5-1 STL (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 9/22/2026: 2-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/30/2026: 5-4 PIT (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +110)
• 8/29/2026: 6-2 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +110)
• 8/28/2026: 4-1 STL (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: +104)
• 5/21/2026: 6-2 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/20/2026: 7-0 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/19/2026: 9-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/30/2026: 10-5 STL (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 4/29/2026: 5-4 STL (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)

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