Notre Dame vs Purdue Prediction, Odds, Picks, Best Bets for Week 4 2026

College football's Saturday schedule includes the Notre Dame Fighting Irish facing the Purdue Boilermakers.

Get the latest NCAA football odds ahead of this game on FanDuel Sportsbook.

Notre Dame vs Purdue Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Notre Dame: (-4545) | Purdue: (+2000)
• Spread: Notre Dame: -27.5 (-118) | Purdue: +27.5 (-104)
• Total: 57.5 -- Over: (-110) | Under: (-110)

Notre Dame vs Purdue Betting Trends

• Notre Dame has won twice against the spread this season.
• Notre Dame owns one win ATS (1-1) as a 27.5-point favorite or greater this year.
• One of Notre Dame's three games this season has hit the over.
• Purdue has posted one win against the spread this season.
• Every Purdue game has hit the over this year.

Notre Dame vs Purdue Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Fighting Irish win (96.3%)

Notre Dame vs Purdue Point Spread

Purdue is a 27.5-point underdog against Notre Dame. Purdue is -104 to cover the spread, and Notre Dame is -118.

Notre Dame vs Purdue Over/Under

A total of 57.5 points has been set for the Notre Dame-Purdue matchup on Sept. 26, with the over available at -110 and the under at -110.

Notre Dame vs Purdue Moneyline

Notre Dame is the favorite, -4545 on the moneyline, while Purdue is a +2000 underdog.

Notre Dame vs. Purdue Points Insights

Notre Dame vs. Purdue Game Info

• Game day: Saturday, September 26, 2026
• Game time: 2 p.m. ET
• TV channel: Peacock
• Location: West Lafayette, Indiana
• Stadium: Ross-Ade Stadium

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Check out even more in-depth Notre Dame vs. Purdue analysis on FanDuel Research.