Athletics vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 9:11 p.m.

In MLB action on Tuesday, the Athletics take on the Los Angeles Angels.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding this game.

Athletics vs Angels Game Info

• Athletics (61-95) vs. Los Angeles Angels (60-96)
• Date: Tuesday, September 22, 2026
• Time: 9:40 p.m. ET
• Venue: Sutter Health Park -- West Sacramento, California
• Coverage: NBCS-CA and ABTV

Athletics vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: OAK: (-108) | LAA: (-108)
• Spread: OAK: +1.5 (-178) | LAA: -1.5 (+146)
• Total: 9.5 -- Over: (-104) | Under: (-118)

Athletics vs Angels Probable Starting Pitchers

Probable Pitchers: Brady Basso (Athletics) - 1-3, 4.50 ERA vs Yusei Kikuchi (Angels) - 1-6, 5.02 ERA

The Athletics will call on Brady Basso (1-3) against the Angels and Yusei Kikuchi (1-6). Basso and his team have a record of 4-2-0 against the spread when he starts. Basso has yet to start a game this season when his team was the moneyline favorite. The Angels have a 4-8-0 record against the spread in Kikuchi's starts. The Angels have been the moneyline underdog in nine of Kikuchi's starts this season, and they went 2-7 in those games.

Athletics vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Athletics win (57.4%)

Athletics vs Angels Moneyline

• The Athletics vs Angels moneyline has the Athletics as a -108 favorite, while the Angels are a -108 underdog on the road.

Athletics vs Angels Spread

Athletics vs Angels Over/Under

• The Athletics-Angels game on Sept. 22 has been given an over/under of 9.5 runs. The over is set at -104 and the under at -118.

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Athletics vs Angels Betting Trends

• The Athletics have come away with 14 wins in the 32 contests they have been listed as the favorites in this season.
• This year, the Athletics have won 16 of 37 games when listed as at least -108 or better on the moneyline.
• The Athletics and their opponents have hit the over in 80 of their 155 games with a total this season.
• In 155 games with a line this season, the Athletics have a mark of 73-82-0 against the spread.
• The Angels have been the moneyline underdog 126 total times this season. They've finished 44-82 in those games.
• The Angels have gone 44-82 when playing as a moneyline underdog with odds of -108 or longer (34.9%).
• The Angels have played in 155 games with a set over/under, and have combined with their opponents to go over the total 64 times (64-88-3).
• The Angels have put together an 82-73-0 record against the spread this season.

Athletics Player Leaders

• Jeff McNeil has an OPS of .680, fueled by an OBP of .313 and a team-best slugging percentage of .367 this season. He has a .266 batting average.
• Among qualifying batters, he is 48th in batting average, his on-base percentage ranks 98th, and he is 118th in slugging.
• Shea Langeliers is batting .263 with 19 doubles, 23 home runs and 35 walks, while slugging .483 with an on-base percentage of .329.
• Zack Gelof has collected 94 base hits, an OBP of .314 and a slugging percentage of .456 this season.
• Gelof heads into this game with four games in a row with at least one hit. During his last five outings he is batting .286 with a home run and four RBIs.
• Lawrence Butler leads the Athletics in OBP (.321) and total hits (102) this season.

Angels Player Leaders

• Zach Neto has a team-best slugging percentage (.433) while pacing the Angels in hits (142). He's batting .237 and with an on-base percentage of .323.
• Including all the qualifying hitters in the majors, his batting average places him 100th, his on-base percentage ranks 83rd, and he is 63rd in slugging.
• Mike Trout has a .381 on-base percentage to pace his team. He has a batting average of .241 while slugging .419.
• His batting average is 95th among all qualified players, his on-base percentage is eighth, and he is 74th in slugging.
• Vaughn Grissom is hitting .237 with 22 doubles, 12 home runs and 30 walks.
• Wade Meckler has 14 doubles, three home runs and 30 walks while batting .289.

Athletics vs Angels Head to Head

• 6/28/2026: 4-1 LAA (Favorite: Athletics, Spread: -1.5, Total: 9.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/27/2026: 5-2 LAA (Favorite: Angels, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/26/2026: 9-3 OAK (Favorite: Athletics, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/21/2026: 9-7 LAA (Favorite: Athletics, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/20/2026: 7-0 LAA (Favorite: Athletics, Spread: -1.5, Total: 9.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 6/19/2026: 12-11 OAK (Favorite: Athletics, Spread: -1.5, Total: 10, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/18/2026: 5-0 OAK (Favorite: Athletics, Spread: -1.5, Total: 10, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 5/21/2026: 3-2 OAK (Favorite: Angels, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/20/2026: 6-5 OAK (Favorite: Athletics, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/19/2026: 14-6 OAK (Favorite: Angels, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)

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