Athletics vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 4:11 a.m.

Tuesday's slate in the MLB includes a matchup between the Athletics and the Los Angeles Angels.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Athletics vs Angels Game Info

• Athletics (61-95) vs. Los Angeles Angels (60-96)
• Date: Tuesday, September 22, 2026
• Time: 9:40 p.m. ET
• Venue: Sutter Health Park -- West Sacramento, California
• Coverage: NBCS-CA and ABTV

Athletics vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: OAK: (-108) | LAA: (-108)
• Spread: OAK: +1.5 (-176) | LAA: -1.5 (+146)
• Total: 9.5 -- Over: (-104) | Under: (-118)

Athletics vs Angels Probable Starting Pitchers

Probable Pitchers: Brady Basso (Athletics) - 1-3, 4.50 ERA vs Yusei Kikuchi (Angels) - 1-6, 5.02 ERA

The probable pitchers are Brady Basso (1-3) for the Athletics and Yusei Kikuchi (1-6) for the Angels. Basso and his team are 4-2-0 ATS this season when he starts. Basso has yet to start a game this season when his team was the moneyline favorite. The Angels have a 4-8-0 record against the spread in Kikuchi's starts. The Angels have a 2-7 record in Kikuchi's nine starts this season when they were the moneyline underdog.

Athletics vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Athletics win (57.2%)

Athletics vs Angels Moneyline

• The Athletics vs Angels moneyline has the Athletics as a -108 favorite, while the Angels are a -108 underdog on the road.

Athletics vs Angels Spread

Athletics vs Angels Over/Under

• The over/under for the Athletics versus Angels game on Sept. 22 has been set at 9.5, with -104 odds on the over and -118 odds on the under.

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Athletics vs Angels Betting Trends

• The Athletics have come away with 14 wins in the 32 contests they have been listed as the favorites in this season.
• This year, the Athletics have won 16 of 37 games when listed as at least -108 or better on the moneyline.
• The Athletics and their opponents have hit the over in 80 of their 155 games with a total this season.
• The Athletics have posted a record of 73-82-0 against the spread this season.
• The Angels have been the moneyline underdog 126 total times this season. They've gone 44-82 in those games.
• The Angels have a record of 44-82 when they have played as a moneyline underdog with odds of -108 or longer (34.9%).
• The Angels have combined with their opponents to go over the total 64 times this season for a 64-88-3 record against the over/under.
• The Angels have gone 82-73-0 against the spread this season.

Athletics Player Leaders

• Jeff McNeil leads Sacramento with a slugging percentage of .367, fueled by 30 extra-base hits. He has a .266 batting average and an on-base percentage of .313.
• He ranks 48th in batting average, 98th in on-base percentage, and 118th in slugging among all qualifying hitters in MLB.
• Shea Langeliers is batting .263 with 19 doubles, 23 home runs and 35 walks. He's slugging .483 with an on-base percentage of .329.
• Zack Gelof is batting .252 with a .456 slugging percentage and 50 RBI this year.
• Gelof has picked up a hit in four straight games. During his last five outings he is hitting .286 with a home run and four RBIs.
• Lawrence Butler leads the Athletics in OBP (.321) and total hits (102) this season.

Angels Player Leaders

• Zach Neto has a slugging percentage of .433 and has 142 hits, both team-high marks for the Angels. He's batting .237 and with an on-base percentage of .323.
• Including all qualified players, he ranks 100th in batting average, while his on-base percentage is 83rd and he is 63rd in slugging.
• Mike Trout has a .381 on-base percentage to pace his team. He has a batting average of .241 while slugging .419.
• He is 95th in batting average, eighth in on-base percentage and 74th in slugging percentage in the majors.
• Vaughn Grissom is hitting .237 with 22 doubles, 12 home runs and 30 walks.
• Wade Meckler has 14 doubles, three home runs and 30 walks while batting .289.

Athletics vs Angels Head to Head

• 6/28/2026: 4-1 LAA (Favorite: Athletics, Spread: -1.5, Total: 9.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/27/2026: 5-2 LAA (Favorite: Angels, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/26/2026: 9-3 OAK (Favorite: Athletics, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/21/2026: 9-7 LAA (Favorite: Athletics, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/20/2026: 7-0 LAA (Favorite: Athletics, Spread: -1.5, Total: 9.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 6/19/2026: 12-11 OAK (Favorite: Athletics, Spread: -1.5, Total: 10, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/18/2026: 5-0 OAK (Favorite: Athletics, Spread: -1.5, Total: 10, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 5/21/2026: 3-2 OAK (Favorite: Angels, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/20/2026: 6-5 OAK (Favorite: Athletics, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/19/2026: 14-6 OAK (Favorite: Angels, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)

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