Twins vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 4:11 a.m.

In MLB action on Tuesday, the Minnesota Twins play the San Francisco Giants.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Twins vs Giants Game Info

• Minnesota Twins (73-84) vs. San Francisco Giants (65-92)
• Date: Tuesday, September 22, 2026
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and Twins.TV

Twins vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-134) | SF: (+114)
• Spread: MIN: -1.5 (+130) | SF: +1.5 (-156)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Twins vs Giants Probable Starting Pitchers

Probable Pitchers: Taj Bradley (Twins) - 11-6, 3.81 ERA vs Anthony Molina (Giants) - 3-1, 4.18 ERA

The probable starters are Taj Bradley (11-6) for the Twins and Anthony Molina (3-1) for the Giants. Bradley and his team have a record of 18-11-0 against the spread when he starts. Bradley's team has been victorious in 70% of the games he's started as the moneyline favorite with a record of 7-3. When Molina starts, the Giants are 3-1-0 against the spread. The Giants have a 3-1 record in Molina's four starts this season when they were the underdog on the moneyline.

Twins vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (52.8%)

Twins vs Giants Moneyline

• Minnesota is the favorite, -134 on the moneyline, while San Francisco is a +114 underdog despite being at home.

Twins vs Giants Spread

• The Twins are at the Giants and are favored by 1.5 runs on the spread. The Twins are +130 to cover the runline, with the Giants being -156.

Twins vs Giants Over/Under

• Twins versus Giants, on Sept. 22, has an over/under of 7.5, with the over being -115 and the under -105.

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Twins vs Giants Betting Trends

• The Twins have been chosen as favorites in 57 games this year and have walked away with the win 30 times (52.6%) in those games.
• This season Minnesota has been victorious 11 times in 21 chances when named as a favorite of at least -134 on the moneyline.
• Contests with the Twins have gone over the total set by bookmakers in 86 of 153 chances this season.
• In 153 games with a line this season, the Twins have a mark of 81-72-0 against the spread.
• The Giants are 40-68 in games they were the underdog on the moneyline (winning 37% of those games).
• San Francisco is 23-39 (winning just 37.1% of its games) when playing as a moneyline underdog of +114 or longer.
• The Giants have had an over/under set by oddsmakers 154 times, and have combined with opponents to go over the total in 76 of those games (76-68-10).
• The Giants have a 74-80-0 record against the spread this season (covering 48.1% of the time).

Twins Player Leaders

• Brooks Lee leads Minnesota in slugging percentage (.434) thanks to 51 extra-base hits. He has a .253 batting average and an on-base percentage of .301.
• He is 74th in batting average, 116th in on-base percentage, and 61st in slugging among qualified hitters in MLB.
• Lee will look for his seventh straight game with a hit in this contest. In his last 10 games he is batting .351 with a double, a home run, two walks and three RBIs.
• Josh Bell has 28 doubles, a triple, 20 home runs and 49 walks. He's batting .258 and slugging .421 with an on-base percentage of .320.
• He is 68th in batting average, 88th in on-base percentage and 73rd in slugging among qualifying hitters.
• Bell takes a five-game streak with at least one hit into this contest. During his last five outings he is batting .364 with a walk and four RBIs.
• Luke Keaschall has 141 hits this season and a team-best OBP of .367.
• Kody Clemens leads Minnesota in total hits (120) this season while batting .234 with 55 extra-base hits.

Giants Player Leaders

• Drew Gilbert has 14 doubles, three triples, 11 home runs and 37 walks while batting .237. He's slugging .396 with an on-base percentage of .327.
• Marcelo Mayer is batting .215 with 10 doubles, three home runs and 16 walks. He's slugging .306 with an on-base percentage of .277.
• Christian Koss has six doubles, four home runs and nine walks while hitting .230.
• Jonah Cox has three doubles, two triples, four home runs and eight walks while hitting .280.

Twins vs Giants Head to Head

• 9/21/2026: 5-2 SF (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/11/2025: 7-6 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/10/2025: 2-1 MIN (Favorite: Giants, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/9/2025: 3-1 MIN (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/14/2024: 3-2 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 7/13/2024: 4-2 MIN (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/12/2024: 7-1 SF (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/24/2023: 7-1 MIN (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 5/23/2023: 4-3 SF (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 5/22/2023: 4-1 SF (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)

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