Twins vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 9:11 p.m.

MLB action on Tuesday includes the Minnesota Twins playing the San Francisco Giants.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Twins vs Giants Game Info

• Minnesota Twins (73-84) vs. San Francisco Giants (65-92)
• Date: Tuesday, September 22, 2026
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and Twins.TV

Twins vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-134) | SF: (+114)
• Spread: MIN: -1.5 (+134) | SF: +1.5 (-162)
• Total: 7.5 -- Over: (+108) | Under: (-132)

Twins vs Giants Probable Starting Pitchers

Probable Pitchers: Taj Bradley (Twins) - 11-6, 3.81 ERA vs Anthony Molina (Giants) - 3-1, 4.18 ERA

The Twins will give the ball to Taj Bradley (11-6, 3.81 ERA), who is eyeing win No. 12 on the season, and the Giants will turn to Anthony Molina (3-1, 4.18 ERA). Bradley's team is 18-11-0 against the spread this season in his starts. When Bradley starts a game and his team is the favorite on the moneyline, they have a record of 7-3. The Giants have gone 3-1-0 against the spread when Molina starts. The Giants have a 3-1 record in Molina's four starts this season when they were the underdog on the moneyline.

Twins vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (50.2%)

Twins vs Giants Moneyline

• San Francisco is a +114 underdog on the moneyline, while Minnesota is a -134 favorite on the road.

Twins vs Giants Spread

• The Twins are favored by 1.5 runs on the road against the Giants. The Twins are +134 to cover the spread, while the Giants are -162.

Twins vs Giants Over/Under

• Twins versus Giants, on Sept. 22, has an over/under of 7.5, with the over being +108 and the under -132.

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Twins vs Giants Betting Trends

• The Twins have won in 30, or 52.6%, of the 57 contests they have been named as odds-on favorites in this year.
• This year Minnesota has won 11 of 21 games when listed as at least -134 on the moneyline.
• The Twins and their opponents have gone over the total this season in 86 of their 153 opportunities.
• The Twins are 81-72-0 against the spread in their 153 games with a line set by sportsbooks this season.
• The Giants are 40-68 in games they were the underdog on the moneyline (winning 37% of those games).
• When playing as a moneyline underdog with odds of +114 or longer, San Francisco has a record of 23-39 (37.1%).
• The Giants have combined with opponents to go over the total 76 times this season for a 76-68-10 record against the over/under.
• The Giants have a 74-80-0 record against the spread this season.

Twins Player Leaders

• Brooks Lee leads Minnesota with a slugging percentage of .434, fueled by 51 extra-base hits. He has a .253 batting average and an on-base percentage of .301.
• Among qualifying batters, he ranks 74th in batting average, his on-base percentage ranks 116th, and he is 61st in slugging.
• Lee has picked up at least one hit in six straight games. During his last 10 outings he is hitting .351 with a double, a home run, two walks and three RBIs.
• Josh Bell is batting .258 with 28 doubles, a triple, 20 home runs and 49 walks. He's slugging .421 with an on-base percentage of .320.
• His batting average ranks 68th among qualified players, his on-base percentage 88th, and his slugging percentage 73rd.
• Bell has picked up at least one hit in five straight games. During his last five outings he is batting .364 with a walk and four RBIs.
• Luke Keaschall leads Minnesota in OBP (.367) this season, fueled by 141 hits.
• Kody Clemens leads Minnesota with 120 hits, batting .234 this season with 55 extra-base hits.

Giants Player Leaders

• Drew Gilbert has 14 doubles, three triples, 11 home runs and 37 walks while batting .237. He's slugging .396 with an on-base percentage of .327.
• Marcelo Mayer has 10 doubles, three home runs and 16 walks while batting .215. He's slugging .306 with an on-base percentage of .277.
• Christian Koss has six doubles, four home runs and nine walks while batting .230.
• Jonah Cox has three doubles, two triples, four home runs and eight walks while batting .280.

Twins vs Giants Head to Head

• 9/21/2026: 5-2 SF (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/11/2025: 7-6 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/10/2025: 2-1 MIN (Favorite: Giants, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/9/2025: 3-1 MIN (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/14/2024: 3-2 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 7/13/2024: 4-2 MIN (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/12/2024: 7-1 SF (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/24/2023: 7-1 MIN (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 5/23/2023: 4-3 SF (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 5/22/2023: 4-1 SF (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)

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