Cubs vs Marlins Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 7:11 p.m.

The Chicago Cubs versus the Miami Marlins is on the MLB schedule for Tuesday.

We've got you covered, in terms of the vital information regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Marlins Game Info

• Chicago Cubs (87-69) vs. Miami Marlins (76-80)
• Date: Tuesday, September 22, 2026
• Time: 7:40 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and Marlins.TV

Cubs vs Marlins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-200) | MIA: (+168)
• Spread: CHC: -1.5 (+114) | MIA: +1.5 (-137)
• Total: 6.5 -- Over: (-120) | Under: (-102)

Cubs vs Marlins Probable Starting Pitchers

Probable Pitchers: Shota Imanaga (Cubs) - 11-10, 3.80 ERA vs Janson Junk (Marlins) - 6-9, 4.50 ERA

The Cubs will give the nod to Shota Imanaga (11-10) against the Marlins and Janson Junk (6-9). Imanaga and his team are 14-15-0 ATS this season when he starts. Imanaga's team is 15-11 this season when he starts and they are the moneyline favorite. The Marlins are 12-11-0 against the spread when Junk starts. The Marlins are 6-7 in Junk's 13 starts this season that they were the moneyline underdog.

Cubs vs Marlins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (62.3%)

Cubs vs Marlins Moneyline

• Miami is a +168 underdog on the moneyline, while Chicago is a -200 favorite at home.

Cubs vs Marlins Spread

• The Cubs are hosting the Marlins and are favored by 1.5 runs on the spread. The Cubs are +114 to cover the runline, with the Marlins being -137.

Cubs vs Marlins Over/Under

• A total of 6.5 runs has been set for the Cubs-Marlins game on Sept. 22, with the over available at -120 and the under at -102.

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Cubs vs Marlins Betting Trends

• The Cubs have been victorious in 59, or 57.3%, of the 103 contests they have been chosen as favorites in this season.
• This season Chicago has come away with a win four times in seven chances when named as a favorite of at least -200 on the moneyline.
• The Cubs and their opponents have hit the over in 86 of their 151 games with a total set by oddsmakers this season.
• The Cubs have posted a record of 73-78-0 against the spread this season.
• The Marlins have won 39.8% of the games this season they were the moneyline underdog (35-53).
• In games it has played as a moneyline underdog with odds of +168 or longer, Miami has a 3-4 record (winning 42.9% of its games).
• The Marlins have played in 154 games with an over/under set, and have combined with opponents to go over the total 79 times (79-73-2).
• The Marlins have covered 51.3% of their games this season, going 79-75-0 against the spread.

Cubs Player Leaders

• Pete Crow-Armstrong leads Chicago in OBP (.371), slugging percentage (.578) and total hits (170) this season. He has a .280 batting average.
• Among qualifying hitters, he ranks 22nd in batting average, his on-base percentage ranks 13th, and he is second in slugging.
• Alex Bregman is hitting .262 with 32 doubles, two triples, 26 home runs and 75 walks, while slugging .452 with an on-base percentage of .352.
• He is 58th in batting average, 41st in on-base percentage and 46th in slugging in MLB.
• Seiya Suzuki has collected 140 base hits, an OBP of .365 and a slugging percentage of .470 this season.
• Suzuki enters this matchup with three games in a row with at least one hit. In his last five games he is hitting .238 with a home run, a walk and four RBIs.
• Nico Hoerner has been key for Chicago with 161 hits, an OBP of .317 plus a slugging percentage of .355.
• Hoerner enters this game on a three-game hitting streak. During his last five outings he is hitting .200 with a double, a walk and two RBIs.

Marlins Player Leaders

• Otto Lopez has a slugging percentage of .442, a team-high for the Marlins. He's batting .305 with an on-base percentage of .348.
• Including all qualified hitters, he is fifth in batting average, while his on-base percentage ranks 45th and he is 52nd in slugging.
• Javier Sanoja has 31 doubles, five triples, 10 home runs and 26 walks while batting .291. He's slugging .454 with an on-base percentage of .330.
• Xavier Edwards has put up a team-high .360 on-base percentage.
• Jakob Marsee has 19 doubles, six triples, 11 home runs and 77 walks while hitting .230.

Cubs vs Marlins Head to Head

• 9/6/2026: 10-3 MIA (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/5/2026: 6-5 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/4/2026: 6-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/21/2025: 2-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 5/20/2025: 14-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/19/2025: 8-7 MIA (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/14/2025: 3-1 MIA (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 5/13/2025: 5-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 5/12/2025: 5-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -255, Underdog Moneyline: +210)
• 8/25/2024: 7-2 MIA (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -176, Underdog Moneyline: +148)

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