Cubs vs Marlins Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 4:11 a.m.

On Tuesday in MLB, the Chicago Cubs are playing the Miami Marlins.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this matchup.

Cubs vs Marlins Game Info

• Chicago Cubs (87-69) vs. Miami Marlins (76-80)
• Date: Tuesday, September 22, 2026
• Time: 7:40 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and Marlins.TV

Cubs vs Marlins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-210) | MIA: (+176)
• Spread: CHC: -1.5 (+114) | MIA: +1.5 (-137)
• Total: 6.5 -- Over: (-115) | Under: (-105)

Cubs vs Marlins Probable Starting Pitchers

Probable Pitchers: Kevin Gausman (Cubs) - 9-12, 4.55 ERA vs Janson Junk (Marlins) - 6-9, 4.50 ERA

The Cubs will give the nod to Kevin Gausman (9-12) versus the Marlins and Janson Junk (6-9). Gausman and his team are 13-18-0 ATS this season when he starts. Gausman's team has won 60% of his starts when they are favored on the moneyline (12-8). The Marlins have a 12-11-0 ATS record in Junk's 23 starts with a set spread. The Marlins are 6-7 in Junk's 13 starts this season that they were the moneyline underdog.

Cubs vs Marlins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (63.7%)

Cubs vs Marlins Moneyline

• Chicago is a -210 favorite on the moneyline, while Miami is a +176 underdog on the road.

Cubs vs Marlins Spread

• The Cubs are hosting the Marlins and are favored by 1.5 runs on the spread. The Cubs are +114 to cover the runline, with the Marlins being -137.

Cubs vs Marlins Over/Under

• The Cubs-Marlins contest on Sept. 22 has been given an over/under of 6.5 runs. The over is set at -115 and the under at -105.

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Cubs vs Marlins Betting Trends

• The Cubs have been chosen as favorites in 103 games this year and have walked away with the win 59 times (57.3%) in those games.
• This year Chicago has won two of four games when listed as at least -210 on the moneyline.
• Contests with the Cubs have gone over the total set by bookmakers in 86 of 151 chances this season.
• In 151 games with a line this season, the Cubs have a mark of 73-78-0 against the spread.
• The Marlins have gone 35-53 in games they were listed as the moneyline underdog (winning 39.8% of those games).
• When it has played as a moneyline underdog with odds of +176 or longer, Miami has a 2-3 record (winning 40% of its games).
• The Marlins have played in 154 games with a set over/under, and have combined with their opponents to go over the total 79 times (79-73-2).
• The Marlins have put together a 79-75-0 record ATS this season.

Cubs Player Leaders

• Pete Crow-Armstrong leads Chicago in OBP (.371), slugging percentage (.578) and total hits (170) this season. He has a .280 batting average.
• He is 23rd in batting average, 13th in on-base percentage, and second in slugging among qualified batters in the majors.
• Alex Bregman is batting .262 with 32 doubles, two triples, 26 home runs and 75 walks, while slugging .452 with an on-base percentage of .352.
• Among qualifying batters, he ranks 58th in batting average, 41st in on-base percentage and 46th in slugging percentage.
• Nico Hoerner has collected 161 base hits, an OBP of .317 and a slugging percentage of .355 this season.
• Hoerner enters this game with three games in a row with at least one hit. During his last five outings he is hitting .200 with a double, a walk and two RBIs.
• Seiya Suzuki has been key for Chicago with 140 hits, an OBP of .365 plus a slugging percentage of .470.
• Suzuki heads into this game on a three-game hitting streak. During his last five outings he is batting .238 with a home run, a walk and four RBIs.

Marlins Player Leaders

• Otto Lopez has a .442 slugging percentage, which leads the Marlins. He's batting .305 with an on-base percentage of .348.
• He ranks fifth in batting average, 45th in on-base percentage and 52nd in slugging percentage among all qualified batters in the majors.
• Javier Sanoja has 31 doubles, five triples, 10 home runs and 26 walks while batting .291. He's slugging .454 with an on-base percentage of .330.
• Xavier Edwards has racked up a team-high .360 on-base percentage.
• Jakob Marsee has 19 doubles, six triples, 11 home runs and 77 walks while batting .230.

Cubs vs Marlins Head to Head

• 9/6/2026: 10-3 MIA (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/5/2026: 6-5 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/4/2026: 6-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/21/2025: 2-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 5/20/2025: 14-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/19/2025: 8-7 MIA (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/14/2025: 3-1 MIA (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 5/13/2025: 5-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 5/12/2025: 5-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -255, Underdog Moneyline: +210)
• 8/25/2024: 7-2 MIA (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -176, Underdog Moneyline: +148)

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