Dodgers vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 9:11 p.m.

The MLB's Tuesday slate includes the Los Angeles Dodgers taking on the San Diego Padres.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Dodgers vs Padres Game Info

• Los Angeles Dodgers (96-60) vs. San Diego Padres (87-69)
• Date: Tuesday, September 22, 2026
• Time: 10:10 p.m. ET
• Venue: Dodger Stadium -- Los Angeles, California
• Coverage: TBS, SportsNet LA, and Padres.TV

Dodgers vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAD: (-130) | SD: (+110)
• Spread: LAD: -1.5 (+155) | SD: +1.5 (-188)
• Total: 8.5 -- Over: (-108) | Under: (-112)

Dodgers vs Padres Probable Starting Pitchers

Probable Pitchers: Brock Stewart (Dodgers) - 1-2, 2.55 ERA vs Michael King (Padres) - 12-9, 3.03 ERA

The Dodgers will look to Brock Stewart (1-2) against the Padres and Michael King (12-9). Stewart did not pitch in a game with a spread last season. Stewart did not appear in a game when his team was the moneyline favorite last season. The Padres are 12-19-0 ATS in King's 31 starts with a set spread. The Padres have been the moneyline underdog in 10 of King's starts this season, and they went 4-6 in those games.

Dodgers vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Dodgers win (59.4%)

Dodgers vs Padres Moneyline

• The Dodgers vs Padres moneyline has Los Angeles as a -130 favorite, while San Diego is a +110 underdog on the road.

Dodgers vs Padres Spread

• The Padres are +1.5 on the spread (-188 to cover), and Los Angeles is +155 to cover the runline.

Dodgers vs Padres Over/Under

• The over/under for the Dodgers versus Padres contest on Sept. 22 has been set at 8.5, with -108 odds on the over and -112 odds on the under.

Bet on Los Angeles Dodgers vs. San Diego Padres on FanDuel today!

Dodgers vs Padres Betting Trends

• The Dodgers have been favorites in 148 games this season and have come away with the win 93 times (62.8%) in those contests.
• Los Angeles has a record of 84-51 in contests when sportsbooks favor them by -130 or more on the moneyline.
• The Dodgers and their opponents have gone over in 73 of their 154 games with a total set by sportsbooks this season.
• The Dodgers are 65-89-0 against the spread in their 154 games with a line set by sportsbooks this season.
• The Padres have won 35 of the 73 games they were the moneyline underdog this season (47.9%).
• San Diego is 15-25 (winning just 37.5% of its games) when playing as a moneyline underdog of +110 or longer.
• The Padres have played in 156 games with an over/under set, and have combined with opponents to go over the total 74 times (74-79-3).
• The Padres have covered 57.7% of their games this season, going 90-66-0 against the spread.

Dodgers Player Leaders

• Freddie Freeman leads Los Angeles with a slugging percentage of .438, fueled by 49 extra-base hits. He has a .292 batting average and an on-base percentage of .367.
• Among qualifying hitters in baseball, he ranks ninth in batting average, 16th in on-base percentage, and 57th in slugging.
• Kyle Tucker is hitting .234 with 23 doubles, four triples, 17 home runs and 77 walks, while slugging .393 with an on-base percentage of .334.
• His batting average ranks 106th among qualified players, his on-base percentage 63rd, and his slugging percentage 95th.
• Mookie Betts has collected 118 base hits, an OBP of .325 and a slugging percentage of .454 this season.
• Andy Pages has 21 home runs, 80 RBI and a batting average of .272 this season.

Padres Player Leaders

• Fernando Tatis Jr. has accumulated an on-base percentage of .355, a slugging percentage of .468, and has 173 hits, all club-bests for the Padres (while batting .285).
• Including all the qualified players in the big leagues, he is 14th in batting average, 39th in on-base percentage and 33rd in slugging percentage.
• Tatis hopes to build on a four-game hitting streak in this matchup. During his last five outings he is hitting .200 with a double, two home runs, two walks and three RBIs.
• Jackson Merrill has 25 doubles, five triples, 26 home runs and 40 walks while batting .255. He's slugging .445 with an on-base percentage of .304.
• He is 72nd in batting average, 112th in on-base percentage and 49th in slugging percentage in MLB.
• Manny Machado is batting .219 with 22 doubles, 28 home runs and 75 walks.
• Xander Bogaerts has 18 doubles, a triple, 12 home runs and 73 walks while hitting .229.

Dodgers vs Padres Head to Head

• 7/5/2026: 5-2 SD (Favorite: Dodgers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 7/4/2026: 3-0 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -255, Underdog Moneyline: +210)
• 7/3/2026: 4-3 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 7/2/2026: 12-7 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 6/28/2026: 4-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/27/2026: 15-3 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 6/26/2026: 7-1 SD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/20/2026: 4-0 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 5/19/2026: 5-4 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/18/2026: 1-0 SD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)

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