Mariners vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 9:11 p.m.

The MLB slate on Tuesday includes the Seattle Mariners facing the Houston Astros.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding this game.

Mariners vs Astros Game Info

• Seattle Mariners (73-83) vs. Houston Astros (77-79)
• Date: Tuesday, September 22, 2026
• Time: 9:40 p.m. ET
• Venue: T-Mobile Park -- Seattle, Washington
• Coverage: Mariners.TV and SCHN

Mariners vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-142) | HOU: (+120)
• Spread: SEA: -1.5 (+152) | HOU: +1.5 (-184)
• Total: 7.5 -- Over: (+104) | Under: (-128)

Mariners vs Astros Probable Starting Pitchers

Probable Pitchers: Logan Gilbert (Mariners) - 12-10, 3.69 ERA vs Cristian Javier (Astros) - 2-6, 5.31 ERA

The Mariners will give the nod to Logan Gilbert (12-10) against the Astros and Cristian Javier (2-6). Gilbert and his team are 15-15-0 ATS this season when he starts. Gilbert's team has a record of 14-9 this season when he starts and they are the favorite on the moneyline. The Astros have gone 4-7-0 against the spread when Javier starts. The Astros are 1-2 in Javier's three starts this season that they were the moneyline underdog.

Mariners vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (58.5%)

Mariners vs Astros Moneyline

• The Mariners vs Astros moneyline has Seattle as a -142 favorite, while Houston is a +120 underdog on the road.

Mariners vs Astros Spread

• The Mariners are hosting the Astros and are favored by 1.5 runs (+152 to cover) on the runline. Houston is -184 to cover.

Mariners vs Astros Over/Under

• The Mariners-Astros contest on Sept. 22 has been given an over/under of 7.5 runs. The over is set at +104 and the under at -128.

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Mariners vs Astros Betting Trends

• The Mariners have been favorites in 119 games this season and have come away with the win 59 times (49.6%) in those contests.
• This season Seattle has been victorious 34 times in 57 chances when named as a favorite of at least -142 on the moneyline.
• Contests with the Mariners have gone over the total set by sportsbooks in 81 of 154 chances this season.
• In 154 games with a line this season, the Mariners have a mark of 56-98-0 against the spread.
• The Astros have gone 40-41 in games they were the underdog on the moneyline (winning 49.4% of those games).
• Houston is 12-17 (winning 41.4% of its games) when it has played as a moneyline underdog of +120 or longer.
• The Astros have had an over/under set by bookmakers 156 times, and have combined with opponents to go over the total in 76 of those games (76-73-7).
• The Astros have gone 77-79-0 against the spread this season.

Mariners Player Leaders

• Randy Arozarena leads Seattle OPS (.857) this season. He has a .279 batting average, an on-base percentage of .376, and a slugging percentage of .481.
• Among qualified hitters in MLB, his batting average ranks 25th, his on-base percentage ranks 11th, and he is 25th in slugging.
• Josh Naylor has an OPS of .682, fueled by an OBP of .323 and a team-best slugging percentage of .359 this season. He's batting .268.
• His batting average is 44th among qualified players, his on-base percentage 83rd, and his slugging percentage 123rd.
• Julio Rodriguez has collected 140 base hits, an OBP of .304 and a slugging percentage of .397 this season.
• Rodriguez has recorded a hit in two games in a row. During his last five outings he is hitting .316 with three doubles, a walk and an RBI.
• Cole Young has been key for Seattle with 137 hits, an OBP of .307 plus a slugging percentage of .385.

Astros Player Leaders

• Yordan Alvarez has racked up an on-base percentage of .430, a slugging percentage of .597, and has 170 hits, all club-highs for the Astros (while batting .313).
• Including all qualifying hitters in the majors, he is first in batting average, first in on-base percentage and first in slugging percentage.
• Alvarez hopes to build on a six-game hitting streak in this matchup. In his last 10 outings he is hitting .294 with three doubles, two home runs, six walks and four RBIs.
• Isaac Paredes is hitting .260 with 26 doubles, a triple, 22 home runs and 67 walks. He's slugging .434 with an on-base percentage of .358.
• His batting average is 63rd among all qualified players, his on-base percentage ranks 33rd, and he is 61st in slugging.
• Christian Walker has 25 doubles, a triple, 25 home runs and 48 walks while batting .221.
• Jose Altuve is batting .249 with 24 doubles, two triples, 16 home runs and 40 walks.

Mariners vs Astros Head to Head

• 8/16/2026: 3-2 SEA (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +114)
• 8/15/2026: 10-5 SEA (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +110)
• 8/14/2026: 10-7 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +112)
• 5/14/2026: 8-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/13/2026: 4-3 HOU (Favorite: Mariners, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/12/2026: 10-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 5/11/2026: 3-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 4/13/2026: 6-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 4/12/2026: 6-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 4/11/2026: 8-7 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -152, Underdog Moneyline: +128)

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