Diamondbacks vs Rockies Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 8:11 p.m.

The Tuesday schedule in MLB includes a matchup between the Arizona Diamondbacks and the Colorado Rockies.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Diamondbacks vs Rockies Game Info

• Arizona Diamondbacks (82-74) vs. Colorado Rockies (57-99)
• Date: Tuesday, September 22, 2026
• Time: 8:40 p.m. ET
• Venue: Coors Field -- Denver, Colorado
• Coverage: Rockies.TV and Dbacks.TV

Diamondbacks vs Rockies Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-184) | COL: (+154)
• Spread: ARI: -1.5 (-118) | COL: +1.5 (-102)
• Total: 10.5 -- Over: (-132) | Under: (+108)

Diamondbacks vs Rockies Probable Starting Pitchers

Probable Pitchers: Mike Soroka (Diamondbacks) - 8-5, 3.45 ERA vs Kyle Freeland (Rockies) - 4-10, 6.38 ERA

The probable pitchers are Mike Soroka (8-5) for the Diamondbacks and Kyle Freeland (4-10) for the Rockies. Soroka's team is 9-9-0 against the spread in his starts this season. Soroka's team has won 58.3% of his starts when they are favored on the moneyline (7-5). The Rockies are 13-12-0 against the spread when Freeland starts. The Rockies have been the moneyline underdog in 24 of Freeland's starts this season, and they went 9-15 in those matchups.

Diamondbacks vs Rockies Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (60.8%)

Diamondbacks vs Rockies Moneyline

• Colorado is the underdog, +154 on the moneyline, while Arizona is a -184 favorite despite being on the road.

Diamondbacks vs Rockies Spread

• The Rockies are +1.5 on the spread (-102 to cover), and Arizona is -118 to cover the runline.

Diamondbacks vs Rockies Over/Under

• A total of 10.5 runs has been set for the Diamondbacks-Rockies game on Sept. 22, with the over available at -132 and the under at +108.

Bet on Arizona Diamondbacks vs. Colorado Rockies on FanDuel today!

Diamondbacks vs Rockies Betting Trends

• The Diamondbacks have come away with 37 wins in the 66 contests they have been listed as the favorites in this season.
• This year Arizona has won four of six games when listed as at least -184 on the moneyline.
• The Diamondbacks and their opponents have hit the over in 67 of their 154 games with a total set by oddsmakers this season.
• The Diamondbacks have posted a record of 80-74-0 against the spread this season.
• The Rockies have been the moneyline underdog 149 total times this season. They've gone 54-95 in those games.
• When playing as a moneyline underdog with odds of +154 or longer, Colorado has gone 17-45 (27.4%).
• The Rockies have had an over/under set by oddsmakers 153 times, and have combined with opponents to go over the total in 75 of those games (75-75-3).
• The Rockies have covered 52.9% of their games this season, going 81-72-0 ATS.

Diamondbacks Player Leaders

• Corbin Carroll is hitting .240 with 31 doubles, 16 triples, 22 home runs and 72 walks. He has an on-base percentage of .331 while slugging .470.
• Among qualified hitters in the majors, he is 98th in batting average, 70th in on-base percentage, and 30th in slugging.
• Ketel Marte is hitting .249 with 29 doubles, three triples, 22 home runs and 48 walks, while slugging .437 with an on-base percentage of .315.
• He ranks 81st in batting average, 96th in on-base percentage and 58th in slugging among qualified hitters.
• Gabriel Moreno leads Arizona with 139 hits and an OBP of .386, plus a team-best slugging percentage of .481.
• Moreno brings a two-game hitting streak into this game. In his last five games he is batting .444 with a double, two home runs, four walks and two RBIs.
• Geraldo Perdomo is batting .256 with a .363 OBP and 52 RBI for Arizona this season.
• Perdomo has hit safely in five straight games. In his last five games he is batting .389 with a triple, three walks and two RBIs.

Rockies Player Leaders

• Jake McCarthy is hitting .297 with 30 doubles, 13 triples, 15 home runs and 29 walks. He's slugging .490 with an on-base percentage of .340.
• Including all qualified hitters in MLB, he ranks eighth in batting average, 54th in on-base percentage and 19th in slugging percentage.
• McCarthy enters this game on a four-game hitting streak. During his last five outings he is batting .300 with three triples, a walk and three RBIs.
• TJ Rumfield paces his team with a .392 on-base percentage, and has a club-best .451 slugging percentage. He has a batting average of .300.
• Including all qualified hitters, he ranks seventh in batting average, third in on-base percentage and 47th in slugging percentage.
• Hunter Goodman paces the Rockies with 121 hits.
• Kyle Karros is batting .258 with 21 doubles, three triples, 12 home runs and 52 walks.

Diamondbacks vs Rockies Head to Head

• 8/12/2026: 6-4 COL (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -172, Underdog Moneyline: +158)
• 8/11/2026: 3-2 COL (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -160, Underdog Moneyline: +148)
• 8/10/2026: 9-0 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -205, Underdog Moneyline: +186)
• 5/24/2026: 9-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 5/23/2026: 5-4 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 5/22/2026: 3-2 COL (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 5/21/2026: 2-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 5/16/2026: 4-2 COL (Favorite: Diamondbacks, Spread: -1.5, Total: 11.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/15/2026: 9-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 11.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/17/2025: 6-5 COL (Favorite: Diamondbacks, Spread: -1.5, Total: 12, Favorite Moneyline: -144, Underdog Moneyline: +122)

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