Astros vs Cubs Prediction, Odds, Moneyline, Spread & Over/Under for June 27

Odds updated as of 4:13 a.m.

MLB action on Friday includes the Houston Astros taking on the Chicago Cubs.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this matchup.

Astros vs Cubs Game Info

• Houston Astros (48-33) vs. Chicago Cubs (48-33)
• Date: Friday, June 27, 2025
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and MARQ

Astros vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-112) | CHC: (-104)
• Spread: HOU: +1.5 (-178) | CHC: -1.5 (+146)
• Total: 8.5 -- Over: (-112) | Under: (-108)

Astros vs Cubs Probable Starting Pitchers

Probable Pitchers: Brandon Walter (Astros) - 0-1, 3.80 ERA vs Cade Horton (Cubs) - 3-1, 3.73 ERA

The Astros will give the nod to Brandon Walter (0-1) versus the Cubs and Cade Horton (3-1). Walter and his team are 2-2-0 ATS this season when he starts. Walter's team won his only start as a favorite this season. The Cubs have gone 4-3-0 against the spread when Horton starts. The Cubs were the underdog on the moneyline for one Horton start this season -- they lost.

Astros vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (51.1%)

Astros vs Cubs Moneyline

• Houston is a -112 favorite on the moneyline, while Chicago is a -104 underdog on the road.

Astros vs Cubs Spread

• The Cubs are 1.5-run favorites against the spread for this matchup with the Astros. The Cubs are +146 to cover, while the Astros are -178 to cover as a 1.5-run underdog on the runline.

Astros vs Cubs Over/Under

• The over/under for Astros-Cubs on June 27 is 8.5. The over is -112, and the under is -108.

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Astros vs Cubs Betting Trends

• The Astros have been chosen as favorites in 55 games this year and have walked away with the win 33 times (60%) in those games.
• Houston has a record of 32-22 when favored by -112 or more this year.
• The Astros and their opponents have gone over the total this season in 31 of their 80 opportunities.
• The Astros have posted a record of 41-39-0 against the spread this season.
• The Cubs are 9-15 in games they were the underdog on the moneyline (winning 37.5% of those games).
• Chicago is 8-12 (winning 40% of its games) when it has played as a moneyline underdog of -104 or longer.
• The Cubs have combined with opponents to hit the over on the total 42 times this season for a 42-33-4 record against the over/under.
• The Cubs are 40-39-0 ATS this season.

Astros Player Leaders

• Jeremy Pena has 102 hits and an OBP of .379 to go with a slugging percentage of .492. All three of those stats are best among Houston hitters this season. He has a .324 batting average, as well.
• Among all qualifying hitters, he ranks fifth in batting average, his on-base percentage ranks 16th, and he is 26th in slugging.
• Pena will look for his fifth straight game with a hit in this contest. In his last five games he is batting .263 with three doubles, a home run, a walk and two RBIs.
• Isaac Paredes is hitting .251 with 10 doubles, a triple, 16 home runs and 42 walks, while slugging .463 with an on-base percentage of .357.
• He is 95th in batting average, 37th in on-base percentage and 49th in slugging among qualifying hitters.
• Jose Altuve has 79 hits this season and has a slash line of .263/.321/.417.
• Jake Meyers has been key for Houston with 79 hits, an OBP of .363 plus a slugging percentage of .399.
• Meyers enters this matchup on a two-game hitting streak. During his last five outings he is hitting .294 with an RBI.

Cubs Player Leaders

• Kyle Tucker has an on-base percentage of .395, a team-best for the Cubs. He's batting .287 and slugging .527.
• Including all the qualified hitters in MLB, his batting average ranks 27th, his on-base percentage ranks fifth, and he is 13th in slugging.
• Pete Crow-Armstrong leads his team with 85 hits. He has a batting average of .272 while slugging .556 with an on-base percentage of .307.
• Including all qualifying hitters, his batting average places him 51st, his on-base percentage ranks 118th, and he is sixth in slugging.
• Seiya Suzuki has 19 doubles, two triples, 21 home runs and 28 walks while hitting .256.
• Nico Hoerner is slugging .368 to lead his team.

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