Astros vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for April 5

Odds updated as of 5:14 a.m.

The Sunday schedule in MLB includes a matchup between the Houston Astros and the Athletics.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Astros vs Athletics Game Info

• Houston Astros (6-3) vs. Athletics (2-6)
• Date: Sunday, April 5, 2026
• Time: 4:05 p.m. ET
• Venue: Sutter Health Park -- West Sacramento, California
• Coverage: NBCS-CA and SCHN

Astros vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-118) | OAK: (+100)
• Spread: HOU: -1.5 (+126) | OAK: +1.5 (-152)
• Total: 10 -- Over: (-105) | Under: (-115)

Astros vs Athletics Probable Starting Pitchers

Probable Pitchers: Lance McCullers (Astros) - 1-0, 1.29 ERA vs Jacob Lopez (Athletics) - 0-1, 6.75 ERA

This contest's pitching matchup is set, as the Astros will send Lance McCullers (1-0) to the mound, while Jacob Lopez (0-1) will take the ball for the Athletics. McCullers helped his team cover the spread in his only opportunity this season as a starter. This will be McCullers' first start this season with his team as the moneyline favorite. Lopez has started just one game with a set spread, which the Athletics failed to cover. The Athletics were the underdog on the moneyline for one Lopez start this season -- they lost.

Astros vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Athletics win (52.9%)

Astros vs Athletics Moneyline

• The Astros vs Athletics moneyline has the Astros as a -118 favorite, while the Athletics are a +100 underdog at home.

Astros vs Athletics Spread

• The Astros are 1.5-run favorites on the runline against the Athletics. The Astros are +126 to cover, while the Athletics are -152 to cover.

Astros vs Athletics Over/Under

• Astros versus Athletics on April 5 has an over/under of 10 runs, with the odds on the over -105 and the under set at -115.

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Astros vs Athletics Betting Trends

• The Astros have won in three of the five contests they have been named as odds-on favorites in this year.
• This season, the Astros have come away with a win three times in five chances when named as a favorite of at least -118 or shorter on the moneyline.
• The Astros and their opponents have hit the over in seven of their nine games with a total this season.
• The Astros have an against the spread record of 6-3-0 in nine games with a line this season.
• The Athletics have gone 1-5 in games they were listed as the moneyline underdog (winning 16.7% of those games).
• When playing as a moneyline underdog with odds of +100 or longer, the Athletics have a record of 1-5 (16.7%).
• The Athletics have combined with their opponents to go over the total three times this season for a 3-5-0 record against the over/under.
• The Athletics have a 4-4-0 record ATS this season.

Astros Player Leaders

• Yordan Alvarez has 11 hits and an OBP of .590 to go with a slugging percentage of .885. All three of those stats rank first among Houston hitters this season. He has a .423 batting average, as well.
• Among qualified hitters in the majors, his batting average ranks fourth, his on-base percentage ranks first, and he is third in slugging.
• Christian Walker leads Houston in slugging percentage (.625) thanks to seven extra-base hits. He's batting .344 with an on-base percentage of .417.
• He is 21st in batting average, 29th in on-base percentage and 17th in slugging among qualifying hitters.
• Jose Altuve is batting .321 with a .571 slugging percentage and four RBI this year.
• Carlos Correa has been key for Houston with eight hits, an OBP of .324 plus a slugging percentage of .364.

Athletics Player Leaders

• Shea Langeliers has accumulated a team-best OBP (.364) and slugging percentage (.800), while leading the Athletics in hits (nine, while batting .300).
• Including all the qualified hitters in the big leagues, his batting average is 43rd, his on-base percentage is 68th, and he is fifth in slugging.
• Max Muncy is slugging .600 to lead his team. He has a batting average of .300 with an on-base percentage of .323.
• Including all qualified hitters, he ranks 43rd in batting average, 104th in on-base percentage and 19th in slugging percentage.
• Jacob Wilson is batting .212 with three doubles.
• Lawrence Butler has a home run and a walk while hitting .200.

Astros vs Athletics Head to Head

• 4/4/2026: 11-0 HOU (Favorite: Athletics, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/3/2026: 11-4 OAK (Favorite: Athletics, Spread: -1.5, Total: 10, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/25/2025: 11-5 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/24/2025: 6-0 OAK (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/23/2025: 5-1 OAK (Favorite: Athletics, Spread: -1.5, Total: 10, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/27/2025: 7-1 OAK (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/26/2025: 5-1 OAK (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 7/25/2025: 15-3 OAK (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/24/2025: 5-2 OAK (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/19/2025: 6-4 OAK (Favorite: Astros, Spread: -1.5, Total: 10.5, Favorite Moneyline: -138, Underdog Moneyline: +118)

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