49ers vs Seahawks Prediction, Odds, Picks, Best Bets for NFL Week 1

The NFL schedule on Sunday includes the San Francisco 49ers taking on the Seattle Seahawks.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NFL moneyline insights you need to know.

49ers vs Seahawks Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: 49ers win (53.4%)

49ers vs Seahawks Point Spread

The 49ers are 1.5-point favorites against the Seahawks. The 49ers are -110 to cover the spread, while the Seahawks are -110 to cover as a 1.5-point underdog.

49ers vs Seahawks Over/Under

A combined point total of 43.5 has been set for 49ers-Seahawks on Sept. 7, with the over at -104 and the under at -118.

49ers vs Seahawks Moneyline

The moneyline numbers for 49ers vs. Seahawks reveal San Francisco as the favorite (-118) and Seattle as the underdog (+100) despite being the home team.

49ers vs Seahawks Betting Trends

• The 49ers covered the spread five times in 17 games last year.
• The 49ers' ATS record as 1.5-point favorites or greater was 5-8 last year.
• There were 11 San Francisco games (out of 17) that hit the over last season.
• Against the spread, the Seahawks were 6-11-0 last season.
• Seattle's ATS record as an underdog of 1.5 points or greater was 5-6 last year.
• In 17 Seahawks games last season, nine of them went over the total.

Check out even more in-depth 49ers vs. Seahawks analysis on FanDuel Research.

49ers vs Seahawks Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-118) | SEA: (+100)
• Spread: SF: -1.5 (-110) | SEA: +1.5 (-110)
• Total: 43.5 -- Over: (-104) | Under: (-118)

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