Twins vs Brewers Prediction, Odds, Moneyline, Spread & Over/Under for May 16

Odds updated as of 7:11 p.m.

The Minnesota Twins will take on the Milwaukee Brewers in MLB action on Friday.

We've got you covered, in terms of the most important info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Twins vs Brewers Game Info

• Minnesota Twins (24-20) vs. Milwaukee Brewers (21-23)
• Date: Friday, May 16, 2025
• Time: 8:10 p.m. ET
• Venue: American Family Field -- Milwaukee, Wisconsin
• Coverage: FDSWI and MNNT

Twins vs Brewers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-120) | MIL: (+102)
• Spread: MIN: -1.5 (+142) | MIL: +1.5 (-172)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Twins vs Brewers Probable Starting Pitchers

Probable Pitchers: Joe Ryan (Twins) - 3-2, 2.74 ERA vs Chad Patrick (Brewers) - 2-3, 3.19 ERA

This contest's pitching matchup is set, as the Twins will send Joe Ryan (3-2) to the mound, while Chad Patrick (2-3) will take the ball for the Brewers. Ryan and his team have a record of 3-5-0 against the spread when he starts. When Ryan starts a game and his team is the favorite on the moneyline, they have a record of 2-3. The Brewers have a 4-3-0 record against the spread in Patrick's starts. The Brewers were the moneyline underdog for two Patrick starts this season -- they lost both.

Twins vs Brewers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (53.9%)

Twins vs Brewers Moneyline

• Milwaukee is the underdog, +102 on the moneyline, while Minnesota is a -120 favorite despite being on the road.

Twins vs Brewers Spread

• The Twins are at the Brewers and are favored by 1.5 runs (+142 to cover) on the runline. Milwaukee is -172 to cover.

Twins vs Brewers Over/Under

• An over/under of 7.5 has been set for Twins-Brewers on May 16, with the over being -115 and the under -105.

Bet on Minnesota Twins vs. Milwaukee Brewers on FanDuel today!

Twins vs Brewers Betting Trends

• The Twins have been favorites in 27 games this season and have come away with the win 15 times (55.6%) in those contests.
• This season Minnesota has come away with a win 13 times in 18 chances when named as a favorite of at least -120 on the moneyline.
• The Twins and their opponents have gone over the total this season in 16 of their 43 opportunities.
• The Twins are 24-19-0 against the spread in their 43 games that had a posted line this season.
• The Brewers have put together a 5-16 record in games they were listed as the moneyline underdog (winning 23.8% of those games).
• Milwaukee has a record of 2-14 when it has played as a moneyline underdog with odds of +102 or longer (12.5%).
• The Brewers have had an over/under set by bookmakers 43 times, and have combined with opponents to go over the total in 17 of those games (17-25-1).
• The Brewers have gone 23-20-0 ATS this season.

Twins Player Leaders

• Byron Buxton leads Minnesota with 41 hits and a team-best slugging percentage of .522. He's batting .261 with an on-base percentage of .312.
• Among qualified hitters in baseball, his batting average ranks 70th, his on-base percentage ranks 105th, and he is 21st in slugging.
• Buxton has hit safely in two games in a row. During his last five outings he is batting .118 with a home run, three walks and two RBIs.
• Trevor Larnach leads Minnesota in OBP (.318) this season, fueled by 39 hits. He's batting .244 while slugging .406.
• His batting average is 102nd among qualified players, his on-base percentage 97th, and his slugging percentage 88th.
• Ty France is batting .252 with a .361 slugging percentage and 21 RBI this year.
• Harrison Bader is batting .300 with a .384 OBP and 18 RBI for Minnesota this season.
• Bader heads into this matchup on a five-game hitting streak. In his last five games he is hitting .400 with two doubles, a walk and two RBIs.

Brewers Player Leaders

• Jackson Chourio has a .457 slugging percentage, which leads the Brewers. He's batting .258 with an on-base percentage of .276.
• Including all qualifying hitters, he ranks 75th in batting average, while his on-base percentage is 141st and he is 55th in slugging.
• Brice Turang is hitting .289 with three doubles, three home runs and 19 walks. He's slugging .368 with an on-base percentage of .368.
• He ranks 35th in batting average, 37th in on-base percentage and 122nd in slugging percentage in MLB.
• William Contreras has three doubles, four home runs and 25 walks while batting .238.
• Rhys Hoskins' 38 hits and .396 OBP are both team-highs.

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