Twins vs Brewers Prediction, Odds, Moneyline, Spread & Over/Under for May 16

Odds updated as of 6:11 a.m.

The MLB slate on Friday includes the Minnesota Twins taking on the Milwaukee Brewers.

We've got you covered, in terms of the vital information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Twins vs Brewers Game Info

• Minnesota Twins (24-20) vs. Milwaukee Brewers (21-23)
• Date: Friday, May 16, 2025
• Time: 8:10 p.m. ET
• Venue: American Family Field -- Milwaukee, Wisconsin
• Coverage: FDSWI and MNNT

Twins vs Brewers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-110) | MIL: (-106)
• Spread: MIN: -1.5 (+146) | MIL: +1.5 (-178)
• Total: 7.5 -- Over: (-120) | Under: (-102)

Twins vs Brewers Probable Starting Pitchers

Probable Pitchers: Joe Ryan (Twins) - 3-2, 2.74 ERA vs Chad Patrick (Brewers) - 2-3, 3.19 ERA

This contest's pitching matchup is set, as the Twins will send Joe Ryan (3-2) to the mound, while Chad Patrick (2-3) will answer the bell for the Brewers. Ryan and his team are 3-5-0 ATS this season when he starts. Ryan's team has a record of 2-3 this season when he starts and they are the favorite on the moneyline. The Brewers are 4-3-0 against the spread when Patrick starts. The Brewers were named the moneyline underdog for two Patrick starts this season -- they lost both.

Twins vs Brewers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (54.2%)

Twins vs Brewers Moneyline

• Looking at the moneyline for Twins-Brewers, Minnesota is the favorite at -110, and Milwaukee is -106 playing at home.

Twins vs Brewers Spread

• The Brewers are hosting the Twins, and are +1.5 on the runline. The Brewers are +146 to cover the spread, and the Twins are -178.

Twins vs Brewers Over/Under

• A total of 7.5 runs has been set for the Twins-Brewers contest on May 16, with the over available at -120 and the under at -102.

Bet on Minnesota Twins vs. Milwaukee Brewers on FanDuel today!

Twins vs Brewers Betting Trends

• The Twins have been chosen as favorites in 27 games this year and have walked away with the win 15 times (55.6%) in those games.
• Minnesota has a record of 15-12 when favored by -110 or more this year.
• The Twins' games have gone over the total in 16 of their 43 opportunities.
• The Twins have an against the spread record of 24-19-0 in 43 games with a line this season.
• The Brewers have won 23.8% of the games this season they were the moneyline underdog (5-16).
• Milwaukee is 4-16 (winning just 20% of its games) when playing as a moneyline underdog of -106 or longer.
• The Brewers have combined with opponents to hit the over on the total 17 times this season for a 17-25-1 record against the over/under.
• The Brewers have collected a 23-20-0 record ATS this season.

Twins Player Leaders

• Byron Buxton has 41 hits to go with a slugging percentage of .522, both of which are tops among Minnesota hitters this season. He has a .261 batting average and an on-base percentage of .312.
• Among qualified batters in the majors, his batting average ranks 70th, his on-base percentage ranks 103rd, and he is 21st in slugging.
• Buxton has recorded at least one hit in two straight games. In his last five games he is hitting .118 with a home run, three walks and two RBIs.
• Trevor Larnach leads Minnesota in OBP (.318) this season, fueled by 39 hits. He's batting .244 while slugging .406.
• Among qualifying batters, his batting average ranks him 101st, his on-base percentage 95th, and his slugging percentage 88th.
• Ty France is batting .252 with a .361 slugging percentage and 21 RBI this year.
• Harrison Bader is batting .300 with a .384 OBP and 18 RBI for Minnesota this season.
• Bader takes a five-game hitting streak into this game. In his last five games he is hitting .400 with two doubles, a walk and two RBIs.

Brewers Player Leaders

• Jackson Chourio has racked up a slugging percentage of .457, a team-best for the Brewers. He's batting .258 with an on-base percentage of .276.
• Including all qualifying hitters, he ranks 75th in batting average, while his on-base percentage is 140th and he is 56th in slugging.
• Brice Turang has three doubles, three home runs and 19 walks while hitting .289. He's slugging .368 with an on-base percentage of .368.
• Including all qualified hitters, he ranks 35th in batting average, 37th in on-base percentage and 120th in slugging percentage.
• William Contreras has three doubles, four home runs and 25 walks while hitting .238.
• Rhys Hoskins leads his team with 38 hits and a .396 on-base percentage.

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