Giants vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for May 16

Odds updated as of 10:11 p.m.

The San Francisco Giants will take on the Athletics in MLB action on Friday.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Giants vs Athletics Game Info

• San Francisco Giants (25-19) vs. Athletics (22-22)
• Date: Friday, May 16, 2025
• Time: 10:15 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: MLB Network, NBCS-BA, and NBCS-CA

Giants vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-196) | OAK: (+164)
• Spread: SF: -1.5 (+114) | OAK: +1.5 (-137)
• Total: 7 -- Over: (-110) | Under: (-110)

Giants vs Athletics Probable Starting Pitchers

Probable Pitchers: Logan Webb (Giants) - 4-3, 2.60 ERA vs JP Sears (Athletics) - 4-2, 2.80 ERA

The Giants will give the nod to Logan Webb (4-3, 2.60 ERA), who is eyeing win No. 5 on the season, and the Athletics will counter with JP Sears (4-2, 2.80 ERA). Webb's team is 5-4-0 against the spread this season in his starts. Webb's team has a record of 4-4 this season when he starts and they are the favorite on the moneyline. The Athletics have a 6-2-0 record against the spread in Sears' starts. The Athletics are 1-2 in Sears' three starts this season that they were the moneyline underdog.

Giants vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (64.2%)

Giants vs Athletics Moneyline

• The Giants vs Athletics moneyline has the Giants as a -196 favorite, while the Athletics are a +164 underdog on the road.

Giants vs Athletics Spread

• The Giants are 1.5-run favorites on the runline against the Athletics. The Giants are +114 to cover, while the Athletics are -137 to cover.

Giants vs Athletics Over/Under

• A combined run total of 7 has been set for Giants-Athletics on May 16, with the over at -110 and the under at -110.

Bet on San Francisco Giants vs. Athletics on FanDuel today!

Giants vs Athletics Betting Trends

• The Giants have been victorious in 16, or 61.5%, of the 26 contests they have been chosen as favorites in this season.
• This season, the Giants have come away with a win three times in four chances when named as a favorite of at least -196 or shorter on the moneyline.
• The Giants and their opponents have hit the over in 25 of their 44 games with a total this season.
• The Giants have posted a record of 23-21-0 against the spread this season.
• The Athletics have put together an 11-17 record in games they were the underdog on the moneyline (winning 39.3% of those games).
• When playing as a moneyline underdog with odds of +164 or longer, the Athletics have a record of 1-3 (25%).
• The Athletics have played in 44 games with a set over/under, and have combined with their opponents to go over the total 24 times (24-17-3).
• The Athletics have a 22-22-0 record ATS this season (covering 50% of the time).

Giants Player Leaders

• Jung Hoo Lee leads San Francisco in slugging percentage (.482) thanks to 19 extra-base hits. He has a .286 batting average and an on-base percentage of .330.
• Among all qualifying hitters, he ranks 38th in batting average, his on-base percentage ranks 81st, and he is 38th in slugging.
• Lee hopes to build on a four-game hitting streak in this matchup. In his last five games he is batting .238 with two home runs and six RBIs.
• Heliot Ramos leads San Francisco in total hits (47) this season while batting .288 with 18 extra-base hits. He's slugging .485 with an on-base percentage of .353.
• Among qualifying batters, he ranks 37th in batting average, 53rd in on-base percentage and 36th in slugging percentage.
• Matt Chapman is batting .219 with a .413 slugging percentage and 24 RBI this year.
• Wilmer Flores has seven home runs, 33 RBI and a batting average of .255 this season.
• Flores brings a three-game hitting streak into this game. In his last five games he is hitting .294 with two walks.

Athletics Player Leaders

• Jacob Wilson has a .377 on-base percentage and a .491 slugging percentage, both team-high numbers for the Athletics. He's batting .347.
• Including all the qualified hitters in the big leagues, he is third in batting average, 28th in on-base percentage and 31st in slugging percentage.
• Tyler Soderstrom has collected 47 hits to lead his team. He has a batting average of .280 while slugging .506 with an on-base percentage of .341.
• He is 47th in batting average, 67th in on-base percentage and 26th in slugging percentage in the majors.
• Shea Langeliers is batting .266 with six doubles, eight home runs and 14 walks.
• Brent Rooker is hitting .249 with seven doubles, a triple, 10 home runs and 14 walks.

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