Padres vs Mariners Prediction, Odds, Moneyline, Spread & Over/Under for May 16

Odds updated as of 9:11 a.m.

The San Diego Padres will face the Seattle Mariners in MLB action on Friday.

We've got you covered, in terms of the vital info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Padres vs Mariners Game Info

• San Diego Padres (27-15) vs. Seattle Mariners (23-19)
• Date: Friday, May 16, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: Apple TV+

Padres vs Mariners Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-154) | SEA: (+130)
• Spread: SD: -1.5 (+140) | SEA: +1.5 (-170)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Padres vs Mariners Probable Starting Pitchers

Probable Pitchers: Stephen Kolek (Padres) - 2-0, 0.00 ERA vs Logan Evans (Mariners) - 1-1, 6.60 ERA

The Padres will call on Stephen Kolek (2-0) against the Mariners and Logan Evans (1-1). Kolek has a record of 2-0-0 ATS in two starts with a spread this season. Kolek's team won his only start as a favorite this season. The Mariners failed to cover in all of Evans' three starts that had a set spread. The Mariners were named the moneyline underdog for one Evans start this season -- they lost.

Padres vs Mariners Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (57.6%)

Padres vs Mariners Moneyline

• San Diego is a -154 favorite on the moneyline, while Seattle is a +130 underdog on the road.

Padres vs Mariners Spread

• The Padres are hosting the Mariners and are favored by 1.5 runs on the spread. The Padres are +140 to cover the runline, with the Mariners being -170.

Padres vs Mariners Over/Under

• Padres versus Mariners on May 16 has an over/under of 8.5 runs, with the odds on the over -115 and the under set at -105.

Bet on San Diego Padres vs. Seattle Mariners on FanDuel today!

Padres vs Mariners Betting Trends

• The Padres have been favorites in 22 games this season and have come away with the win 16 times (72.7%) in those contests.
• This season San Diego has been victorious 10 times in 12 chances when named as a favorite of at least -154 on the moneyline.
• The Padres and their opponents have hit the over in 19 of their 41 games with a total set by oddsmakers this season.
• The Padres have posted a record of 25-16-0 against the spread this season.
• The Mariners have won eight of the 16 games they were listed as the moneyline underdog this season (50%).
• Seattle has played as a moneyline underdog of +130 or longer in only two games this season, which it split 1-1.
• The Mariners have had an over/under set by bookmakers 42 times, and have combined with opponents to go over the total in 25 of those games (25-15-2).
• The Mariners have a 20-22-0 record against the spread this season.

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego with 49 hits, batting .308 this season with 17 extra-base hits. He has an on-base percentage of .383 and a slugging percentage of .560.
• Among all qualifying hitters in MLB, he is 18th in batting average, 22nd in on-base percentage, and 10th in slugging.
• Manny Machado is slashing .340/.410/.490 this season and leads the Padres with an OPS of .901.
• Among qualified hitters, he ranks fifth in batting average, seventh in on-base percentage and 33rd in slugging percentage.
• Machado has picked up at least one hit in 14 straight games. During his last 10 games he is hitting .543 with four doubles, seven walks and six RBIs.
• Luis Arraez has collected 42 base hits, an OBP of .323 and a slugging percentage of .401 this season.
• Arraez has picked up a hit in three straight games. During his last five outings he is hitting .261 with a triple and three RBIs.
• Xander Bogaerts has three home runs, 20 RBI and a batting average of .243 this season.
• Bogaerts has safely hit in two games in a row. During his last five outings he is hitting .250 with two home runs, three walks and five RBIs.

Mariners Player Leaders

• Cal Raleigh has racked up 38 hits, a team-best for the Mariners. He's batting .248 and slugging .556 with an on-base percentage of .368.
• He ranks 96th in batting average, 37th in on-base percentage and 11th in slugging percentage among all qualified hitters in MLB.
• Raleigh enters this game on a three-game hitting streak. In his last five games he is batting .250 with a double, a home run, three walks and three RBIs.
• Jorge Polanco is batting .324 with six doubles, 10 home runs and eight walks. He's slugging .657 with an on-base percentage of .373.
• Julio Rodriguez has a team-best .406 slugging percentage.
• Randy Arozarena leads his team with a .385 OBP.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!