Padres vs Mariners Prediction, Odds, Moneyline, Spread & Over/Under for May 16

Odds updated as of 9:12 p.m.

The Friday schedule in MLB includes a matchup between the San Diego Padres and the Seattle Mariners.

We've got you covered, in terms of the vital information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Padres vs Mariners Game Info

• San Diego Padres (27-15) vs. Seattle Mariners (23-19)
• Date: Friday, May 16, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: Apple TV+

Padres vs Mariners Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-166) | SEA: (+140)
• Spread: SD: -1.5 (+118) | SEA: +1.5 (-142)
• Total: 8.5 -- Over: (-120) | Under: (-102)

Padres vs Mariners Probable Starting Pitchers

Probable Pitchers: Stephen Kolek (Padres) - 2-0, 0.00 ERA vs Logan Evans (Mariners) - 1-1, 6.60 ERA

The Padres will give the ball to Stephen Kolek (2-0, 0.00 ERA), who is eyeing win No. 3 on the season, and the Mariners will turn to Logan Evans (1-1, 6.60 ERA). Kolek has a record of 2-0-0 ATS in two starts with a spread this season. Kolek's team won his only start as a favorite this season. The Mariners have failed to cover in each of the three games Evans started that had a spread set by oddsmakers. The Mariners were the moneyline underdog for one Evans start this season -- they lost.

Padres vs Mariners Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (57.6%)

Padres vs Mariners Moneyline

• Seattle is a +140 underdog on the moneyline, while San Diego is a -166 favorite at home.

Padres vs Mariners Spread

• The Mariners are at the Padres, and are +1.5 on the runline. The Mariners are +118 to cover the spread, and the Padres are -142.

Padres vs Mariners Over/Under

• A combined run total of 8.5 has been set for Padres-Mariners on May 16, with the over at -120 and the under at -102.

Bet on San Diego Padres vs. Seattle Mariners on FanDuel today!

Padres vs Mariners Betting Trends

• The Padres have been chosen as favorites in 22 games this year and have walked away with the win 16 times (72.7%) in those games.
• This season San Diego has come away with a win eight times in 10 chances when named as a favorite of at least -166 on the moneyline.
• The Padres' games have gone over the total in 19 of their 41 opportunities.
• The Padres have an against the spread mark of 25-16-0 in 41 games with a line this season.
• The Mariners have won eight of the 16 games they were listed as the moneyline underdog this season (50%).
• Seattle has played as a moneyline underdog of +140 or longer in only two games this season, which it split 1-1.
• The Mariners have played in 42 games with a set over/under, and have combined with their opponents to go over the total 25 times (25-15-2).
• The Mariners are 20-22-0 ATS this season.

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego with 49 hits, batting .308 this season with 17 extra-base hits. He has an on-base percentage of .383 and a slugging percentage of .560.
• Among qualified hitters, he ranks 18th in batting average, his on-base percentage ranks 22nd, and he is 11th in slugging.
• Manny Machado leads the Padres with an OPS of .901. He has a slash line of .340/.410/.490 this season.
• His batting average is fifth among qualified players, his on-base percentage seventh, and his slugging percentage 33rd.
• Machado has picked up a hit in 14 games in a row. During his last 10 games he is batting .543 with four doubles, seven walks and six RBIs.
• Luis Arraez has collected 42 base hits, an OBP of .323 and a slugging percentage of .401 this season.
• Arraez brings a three-game hitting streak into this game. During his last five outings he is hitting .261 with a triple and three RBIs.
• Xander Bogaerts has been key for San Diego with 35 hits, an OBP of .331 plus a slugging percentage of .368.
• Bogaerts brings a two-game hitting streak into this matchup. In his last five games he is hitting .250 with two home runs, three walks and five RBIs.

Mariners Player Leaders

• Cal Raleigh has 38 hits, a team-best for the Mariners. He's batting .248 and slugging .556 with an on-base percentage of .368.
• Including all qualified players in MLB, he ranks 96th in batting average, 37th in on-base percentage and 12th in slugging percentage.
• Raleigh enters this game on a three-game hitting streak. In his last five games he is hitting .250 with a double, a home run, three walks and three RBIs.
• Jorge Polanco is batting .324 with six doubles, 10 home runs and eight walks. He's slugging .657 with an on-base percentage of .373.
• Julio Rodriguez has put up a slugging percentage of .406, a team-high for the Mariners.
• Randy Arozarena has a .385 on-base percentage to lead his team.

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