Tigers vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 4

Odds updated as of 5:11 p.m.

MLB action on Monday includes the Boston Red Sox taking on the Detroit Tigers.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Red Sox vs Tigers Game Info

• Boston Red Sox (13-21) vs. Detroit Tigers (18-17)
• Date: Monday, May 4, 2026
• Time: 6:10 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: DSN and NESN

Red Sox vs Tigers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-116) | DET: (-102)
• Spread: BOS: -1.5 (+142) | DET: +1.5 (-172)
• Total: 8 -- Over: (-120) | Under: (-102)

Red Sox vs Tigers Probable Starting Pitchers

Probable Pitchers: Payton Tolle (Red Sox) - 0-1, 3.37 ERA vs Tyler Holton (Tigers) - 0-1, 5.27 ERA

The Red Sox will give the nod to Payton Tolle (0-1, 3.37 ERA), who is eyeing win No. 1 on the season, and the Tigers will counter with Tyler Holton (0-1, 5.27 ERA). Tolle has a record of 0-2-0 ATS in two starts with a spread this season. Tolle has yet to start a game this season when his team was the moneyline favorite. Holton has started just one game with a set spread, which the Tigers covered. The Tigers have not been the underdog on the moneyline when Holton starts this season.

Red Sox vs Tigers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (66.6%)

Red Sox vs Tigers Moneyline

• Detroit is the underdog, -102 on the moneyline, while Boston is a -116 favorite despite being on the road.

Red Sox vs Tigers Spread

• The Tigers are hosting the Red Sox, and are +1.5 on the runline. The Tigers are +142 to cover the spread, and the Red Sox are -172.

Red Sox vs Tigers Over/Under

• Red Sox versus Tigers, on May 4, has an over/under of 8, with the over being -120 and the under -102.

Bet on Boston Red Sox vs. Detroit Tigers on FanDuel today!

Red Sox vs Tigers Betting Trends

• The Red Sox have been victorious in 10, or 43.5%, of the 23 contests they have been chosen as favorites in this season.
• This year Boston has won 10 of 23 games when listed as at least -116 on the moneyline.
• The Red Sox and their opponents have gone over the total this season in 16 of their 34 opportunities.
• In 34 games with a line this season, the Red Sox have a mark of 11-23-0 against the spread.
• The Tigers are 5-5 in games they were listed as the moneyline underdog (winning 50% of those games).
• Detroit has a 4-5 record (winning 44.4% of its games) when playing as a moneyline underdog of -102 or longer.
• The Tigers have played in 35 games with an over/under set, and have combined with opponents to go over the total 16 times (16-18-1).
• The Tigers have an 18-17-0 record against the spread this season (covering 51.4% of the time).

Red Sox Player Leaders

• Wilyer Abreu leads Boston in slugging percentage (.460) thanks to 11 extra-base hits. He has a .298 batting average and an on-base percentage of .379.
• Among all qualified hitters, he is 31st in batting average, his on-base percentage ranks 35th, and he is 52nd in slugging.
• Willson Contreras has 33 hits and an OBP of .387, both of which lead the Red Sox this season. He's batting .280 and slugging .492.
• Among all qualifying players, he ranks 42nd in batting average, 24th in on-base percentage and 36th in slugging percentage.
• Contreras enters this matchup looking to extend his eight-game hit streak. In his last 10 games he is batting .316 with two doubles, three home runs, three walks and nine RBIs.
• Jarren Duran has 21 hits this season and has a slash line of .186/.246/.310.
• Duran heads into this game with three games in a row with at least one hit. In his last five games he is batting .222 with two home runs, a walk and four RBIs.
• Caleb Durbin has been key for Boston with 18 hits, an OBP of .254 plus a slugging percentage of .248.

Tigers Player Leaders

• Kevin McGonigle has put up a .407 on-base percentage and a .477 slugging percentage, both team-best numbers for the Tigers. He's batting .315.
• He is 16th in batting average, 11th in on-base percentage and 42nd in slugging percentage among all qualifying hitters in the majors.
• Riley Greene has eight doubles, four home runs and 21 walks while batting .290. He's slugging .452 with an on-base percentage of .393.
• Including all qualifying hitters, he is 36th in batting average, 18th in on-base percentage and 56th in slugging percentage.
• Dillon Dingler paces the Tigers with 26 hits.
• Gleyber Torres is hitting .259 with two doubles, two home runs and 25 walks.

Red Sox vs Tigers Head to Head

• 4/20/2026: 8-6 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/19/2026: 6-2 DET (Favorite: Red Sox, Spread: -1.5, Total: 7, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/18/2026: 4-1 DET (Favorite: Tigers, Spread: -1.5, Total: 6.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/17/2026: 1-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/28/2025: 4-3 BOS (Favorite: Tigers, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/27/2025: 2-1 DET (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/26/2025: 4-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/14/2025: 6-5 DET (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 5/13/2025: 10-9 DET (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/12/2025: 14-2 DET (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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