Tigers vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for May 22

Odds updated as of 6:11 p.m.

MLB action on Thursday includes the Detroit Tigers taking on the Cleveland Guardians.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Tigers vs Guardians Game Info

• Detroit Tigers (33-17) vs. Cleveland Guardians (26-22)
• Date: Thursday, May 22, 2025
• Time: 6:40 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: MLB Network, FDSDET, and CLEG

Tigers vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-124) | CLE: (+106)
• Spread: DET: -1.5 (+164) | CLE: +1.5 (-200)
• Total: 8 -- Over: (-112) | Under: (-108)

Tigers vs Guardians Probable Starting Pitchers

Probable Pitchers: Jack Flaherty (Tigers) - 2-5, 4.44 ERA vs Tanner Bibee (Guardians) - 3-4, 4.06 ERA

This contest's pitching matchup is set, as the Tigers will send Jack Flaherty (2-5) to the mound, while Tanner Bibee (3-4) will take the ball for the Guardians. When Flaherty starts, his team is 2-7-0 against the spread this season. Flaherty's team has a record of 2-3 this season when he starts and they are the favorite on the moneyline. The Guardians have a 3-5-0 ATS record in Bibee's eight starts with a set spread. The Guardians have a 1-2 record in Bibee's three starts this season when they were the moneyline underdog.

Tigers vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (60.6%)

Tigers vs Guardians Moneyline

• The moneyline numbers for Tigers vs. Guardians reveal Detroit as the favorite (-124) and Cleveland as the underdog (+106) on the road.

Tigers vs Guardians Spread

• The Guardians are +1.5 on the run line against the Tigers. The Guardians are -200 to cover, and the Tigers are +164.

Tigers vs Guardians Over/Under

• Tigers versus Guardians, on May 22, has an over/under of 8, with the over being -112 and the under -108.

Bet on Detroit Tigers vs. Cleveland Guardians on FanDuel today!

Tigers vs Guardians Betting Trends

• The Tigers have been victorious in 21, or 75%, of the 28 contests they have been chosen as favorites in this season.
• This year Detroit has won 19 of 24 games when listed as at least -124 on the moneyline.
• Contests with the Tigers have gone over the total set by sportsbooks in 25 of 49 chances this season.
• The Tigers have an against the spread mark of 27-22-0 in 49 games with a line this season.
• The Guardians have won 13 of the 27 games they were the underdog on the moneyline this season (48.1%).
• In games it has played as a moneyline underdog with odds of +106 or longer, Cleveland has a 5-10 record (winning just 33.3% of its games).
• The Guardians have played in 46 games with an over/under set, and have combined with opponents to go over the total 22 times (22-22-2).
• The Guardians have put together a 21-25-0 record against the spread this season (covering 45.7% of the time).

Tigers Player Leaders

• Spencer Torkelson leads Detroit in total hits (43) this season while batting .249 with 25 extra-base hits. He has an on-base percentage of .357 and a slugging percentage of .532.
• He is 91st in batting average, 46th in on-base percentage, and 16th in slugging among qualified hitters in MLB.
• Riley Greene leads Detroit with 54 hits and a team-best slugging percentage of .532. He's batting .287 with an on-base percentage of .343.
• He ranks 32nd in batting average, 63rd in on-base percentage and 16th in slugging in MLB.
• Greene has picked up a hit in four straight games. During his last five outings he is batting .368 with two doubles, a home run, two walks and four RBIs.
• Gleyber Torres has 39 hits this season and has a slash line of .281/.363/.432.
• Kerry Carpenter has been key for Detroit with 47 hits, an OBP of .309 plus a slugging percentage of .503.

Guardians Player Leaders

• Jose Ramirez has 52 hits, a team-best for the Guardians. He's batting .304 and slugging .520 with an on-base percentage of .363.
• Including all qualifying players in the majors, he ranks 17th in batting average, 38th in on-base percentage and 22nd in slugging percentage.
• Ramirez brings a 14-game hitting streak into this game. During his last 10 games he is batting .395 with three doubles, three home runs, four walks and six RBIs.
• Steven Kwan's .377 on-base percentage and .439 slugging percentage both pace his team. He has a batting average of .317.
• He is currently seventh in batting average, 23rd in on-base percentage and 62nd in slugging percentage among all qualifying hitters.
• Carlos Santana has three doubles, six home runs and 24 walks while hitting .231.
• Kyle Manzardo is hitting .216 with five doubles, two triples, 10 home runs and 19 walks.

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