Tigers vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for May 22

Odds updated as of 6:11 a.m.

The MLB schedule on Thursday includes the Detroit Tigers taking on the Cleveland Guardians.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Tigers vs Guardians Game Info

• Detroit Tigers (33-17) vs. Cleveland Guardians (26-22)
• Date: Thursday, May 22, 2025
• Time: 6:40 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: MLB Network, FDSDET, and CLEG

Tigers vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-142) | CLE: (+120)
• Spread: DET: -1.5 (+152) | CLE: +1.5 (-184)
• Total: 8 -- Over: (-105) | Under: (-115)

Tigers vs Guardians Probable Starting Pitchers

Probable Pitchers: Jack Flaherty (Tigers) - 2-5, 4.44 ERA vs Tanner Bibee (Guardians) - 3-4, 4.06 ERA

The Tigers will give the nod to Jack Flaherty (2-5) versus the Guardians and Tanner Bibee (3-4). Flaherty and his team have a record of 2-7-0 against the spread when he starts. When Flaherty starts a game and his team is the favorite on the moneyline, they have a record of 2-3. The Guardians are 3-5-0 against the spread when Bibee starts. The Guardians are 1-2 in Bibee's three starts this season that they were the underdog on the moneyline.

Tigers vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (61.9%)

Tigers vs Guardians Moneyline

• The moneyline numbers for Tigers vs. Guardians reveal Detroit as the favorite (-142) and Cleveland as the underdog (+120) on the road.

Tigers vs Guardians Spread

• The Tigers are hosting the Guardians and are favored by 1.5 runs on the spread. The Tigers are +152 to cover the runline, with the Guardians being -184.

Tigers vs Guardians Over/Under

• Tigers versus Guardians, on May 22, has an over/under of 8, with the over being -105 and the under -115.

Bet on Detroit Tigers vs. Cleveland Guardians on FanDuel today!

Tigers vs Guardians Betting Trends

• The Tigers have won in 21, or 75%, of the 28 contests they have been named as odds-on favorites in this year.
• Detroit has a record of 18-2 when favored by -142 or more this year.
• The Tigers and their opponents have gone over in 25 of their 49 games with a total set by sportsbooks this season.
• The Tigers are 27-22-0 against the spread in their 49 games that had a posted line this season.
• The Guardians have won 13 of the 27 games they were listed as the moneyline underdog this season (48.1%).
• Cleveland has a 4-5 record (winning 44.4% of its games) when it has played as a moneyline underdog of +120 or longer.
• The Guardians have played in 46 games with a set over/under, and have combined with opponents to go over the total 22 times (22-22-2).
• The Guardians have collected a 21-25-0 record ATS this season (covering 45.7% of the time).

Tigers Player Leaders

• Spencer Torkelson leads Detroit with 43 hits, batting .249 this season with 25 extra-base hits. He has an on-base percentage of .357 and a slugging percentage of .532.
• Among all qualified hitters in the majors, his batting average ranks 92nd, his on-base percentage ranks 46th, and he is 17th in slugging.
• Riley Greene leads Detroit in slugging percentage (.532) and total hits (54) this season. He's batting .287 with an on-base percentage of .343.
• His batting average ranks 33rd among qualified players, his on-base percentage 63rd, and his slugging percentage 17th.
• Greene brings a four-game streak with at least one hit into this contest. In his last five games he is hitting .368 with two doubles, a home run, two walks and four RBIs.
• Gleyber Torres has 39 hits this season and has a slash line of .281/.363/.432.
• Kerry Carpenter is batting .278 with a .309 OBP and 22 RBI for Detroit this season.

Guardians Player Leaders

• Jose Ramirez has 52 hits, a team-best for the Guardians. He's batting .304 and slugging .520 with an on-base percentage of .363.
• Including all the qualified hitters in the big leagues, his batting average is 18th, his on-base percentage ranks 39th, and he is 22nd in slugging.
• Ramirez hopes to build on a 14-game hitting streak in this matchup. During his last 10 games he is hitting .395 with three doubles, three home runs, four walks and six RBIs.
• Steven Kwan's .377 OBP and .439 slugging percentage both lead his team. He has a batting average of .317.
• Including all qualified hitters, his batting average puts him seventh, his on-base percentage ranks 24th, and he is 62nd in slugging.
• Carlos Santana is hitting .231 with three doubles, six home runs and 24 walks.
• Kyle Manzardo is hitting .216 with five doubles, two triples, 10 home runs and 19 walks.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!