Brewers vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for May 22

Odds updated as of 6:11 p.m.

MLB action on Thursday includes the Milwaukee Brewers playing the Pittsburgh Pirates.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Brewers vs Pirates Game Info

• Milwaukee Brewers (24-26) vs. Pittsburgh Pirates (17-33)
• Date: Thursday, May 22, 2025
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and FDSWI

Brewers vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-112) | PIT: (-104)
• Spread: MIL: -1.5 (+134) | PIT: +1.5 (-162)
• Total: 9 -- Over: (-102) | Under: (-120)

Brewers vs Pirates Probable Starting Pitchers

Probable Pitchers: Aaron Civale (Brewers) - 0-1, 15.00 ERA vs Mike Burrows (Pirates) - 0-0, 0.00 ERA

The Brewers will call on Aaron Civale (0-1) against the Pirates and Mike Burrows. Civale and his team failed to cover the spread in his only opportunity this season as a starter. This will be Civale's first start this season with his team as the moneyline favorite. Burrows' team was never a moneyline underdog a season ago in games he pitched.

Brewers vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (53.3%)

Brewers vs Pirates Moneyline

• Pittsburgh is the underdog, -104 on the moneyline, while Milwaukee is a -112 favorite despite being on the road.

Brewers vs Pirates Spread

• The Brewers are 1.5-run road favorites on the runline against the Pirates. The Brewers are +134 to cover, and the Pirates are -162.

Brewers vs Pirates Over/Under

• A combined run total of 9 has been set for Brewers-Pirates on May 22, with the over at -102 and the under at -120.

Bet on Milwaukee Brewers vs. Pittsburgh Pirates on FanDuel today!

Brewers vs Pirates Betting Trends

• The Brewers have come away with 17 wins in the 25 contests they have been listed as the favorites in this season.
• This year Milwaukee has won 16 of 23 games when listed as at least -112 on the moneyline.
• The Brewers and their opponents have gone over the total this season in 19 of their 49 opportunities.
• The Brewers are 26-23-0 against the spread in their 49 games with a line set by sportsbooks this season.
• The Pirates have won 12 of the 33 games they were the underdog on the moneyline this season (36.4%).
• Pittsburgh has gone 11-21 when playing as a moneyline underdog with odds of -104 or longer (34.4%).
• The Pirates have had an over/under set by bookmakers 48 times, and have combined with opponents to go over the total in 17 of those games (17-28-3).
• The Pirates have put together a 20-28-0 record ATS this season.

Brewers Player Leaders

• Brice Turang leads Milwaukee with a slugging percentage of .379, fueled by eight extra-base hits. He has a .288 batting average and an on-base percentage of .363.
• Among all qualifying hitters in the majors, he is 31st in batting average, 38th in on-base percentage, and 112th in slugging.
• William Contreras is hitting .255 with six doubles, four home runs and 31 walks, while slugging .366 with an on-base percentage of .373.
• He is 81st in batting average, 29th in on-base percentage and 121st in slugging among qualified hitters.
• Rhys Hoskins leads his team in OBP (.402) and total hits (45) this season.
• Hoskins enters this game with five games in a row with at least one hit. In his last five games he is hitting .412 with two doubles, two home runs, three walks and three RBIs.
• Jackson Chourio leads Milwaukee in slugging percentage (.415) thanks to 22 extra-base hits.
• Chourio takes a two-game hitting streak into this game. In his last five games he is batting .136 with a walk and an RBI.

Pirates Player Leaders

• Oneil Cruz has accumulated a team-best OBP (.350), while leading the Pirates in hits (32). He's batting .221 and slugging.
• Including all the qualified hitters in the majors, his batting average ranks 133rd, his on-base percentage ranks 56th, and he is 76th in slugging.
• Andrew McCutchen is batting .243 with seven doubles, three home runs and 20 walks. He's slugging .357 with an on-base percentage of .344.
• Including all qualified players, he is 94th in batting average, 60th in on-base percentage and 131st in slugging percentage.
• Bryan Reynolds is batting .203 with five doubles, six home runs and 17 walks.
• Ke'Bryan Hayes paces his team with a .310 slugging percentage.

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