Mariners vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for May 22

Odds updated as of 5:13 a.m.

The Seattle Mariners will face the Houston Astros in MLB action on Thursday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this game.

Mariners vs Astros Game Info

• Seattle Mariners (28-20) vs. Houston Astros (25-24)
• Date: Thursday, May 22, 2025
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and ROOT Sports NW

Mariners vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-130) | HOU: (+110)
• Spread: SEA: -1.5 (+116) | HOU: +1.5 (-140)
• Total: 8.5 -- Over: (-102) | Under: (-120)

Mariners vs Astros Probable Starting Pitchers

Probable Pitchers: George Kirby (Mariners) - 0-0, 0.00 ERA vs Lance McCullers (Astros) - 0-1, 7.88 ERA

The Mariners will give the nod to George Kirby and the Astros will counter with Lance McCullers (0-1, 7.88 ERA). In games Kirby pitched with a spread last season, his team was 15-18-0 ATS. Kirby appeared in 23 games last season as the moneyline favorite and his team finished with a record of 12-11 in those contests. The Astros have a 1-2-0 ATS record in McCullers' three starts with a set spread. The Astros were the underdog on the moneyline for one McCullers start this season -- they won.

Mariners vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (50.5%)

Mariners vs Astros Moneyline

• Houston is a +110 underdog on the moneyline, while Seattle is a -130 favorite on the road.

Mariners vs Astros Spread

• The Mariners are favored by 1.5 runs on the road against the Astros. The Mariners are +116 to cover the spread, while the Astros are -140.

Mariners vs Astros Over/Under

• Mariners versus Astros, on May 22, has an over/under of 8.5, with the over being -102 and the under -120.

Bet on Seattle Mariners vs. Houston Astros on FanDuel today!

Mariners vs Astros Betting Trends

• The Mariners have come away with 17 wins in the 28 contests they have been listed as the favorites in this season.
• Seattle has a record of 14-7 in contests when sportsbooks favor them by -130 or more on the moneyline.
• The Mariners' games have gone over the total in 26 of their 47 opportunities.
• The Mariners are 24-23-0 against the spread in their 47 games with a line set by sportsbooks this season.
• The Astros have won 46.7% of the games this season they were the underdog on the moneyline (7-8).
• Houston has gone 3-3 when playing as a moneyline underdog with odds of +110 or longer (50%).
• The Astros have played in 49 games with an over/under set, and have combined with their opponents to go over the total 20 times (20-27-2).
• The Astros are 26-23-0 against the spread this season.

Mariners Player Leaders

• Cal Raleigh leads Seattle in total hits (43) this season while batting .249 with 26 extra-base hits. He has an on-base percentage of .370 and a slugging percentage of .584.
• Among all qualified hitters in MLB, his batting average ranks 92nd, his on-base percentage ranks 33rd, and he is fifth in slugging.
• Raleigh has recorded at least one hit in two games in a row. During his last five outings he is hitting .235 with two doubles, two home runs, four walks and three RBIs.
• Julio Rodriguez has an OPS of .724, fueled by an OBP of .309 and a team-best slugging percentage of .415 this season. He's batting .231.
• His batting average ranks 117th among qualified players, his on-base percentage 107th, and his slugging percentage 84th.
• Jorge Polanco has 37 hits this season and has a slash line of .298/.353/.589.
• J.P. Crawford leads Seattle in OBP (.391) this season, fueled by 43 hits.

Astros Player Leaders

• Isaac Paredes has put up an on-base percentage of .378 and has 48 hits, both team-best numbers for the Astros. He's batting .270 and slugging .483.
• Including all qualified hitters in the majors, his batting average places him 60th, his on-base percentage is 23rd, and he is 36th in slugging.
• Paredes hopes to build on a six-game hitting streak in this matchup. During his last 10 outings he is batting .289 with six home runs, five walks and 11 RBIs.
• Jeremy Pena's .438 slugging percentage paces his team. He has a batting average of .297 with an on-base percentage of .356.
• His batting average ranks 22nd among all qualified players, his on-base percentage is 49th, and he is 64th in slugging.
• Jake Meyers has seven doubles, a triple, three home runs and 15 walks while hitting .306.
• Jose Altuve is hitting .238 with six doubles, four home runs and 15 walks.

Mariners vs Astros Head to Head

• 4/9/2025: 7-6 SEA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/8/2025: 2-1 HOU (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/7/2025: 4-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 9/25/2024: 8-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/24/2024: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/23/2024: 6-1 SEA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/21/2024: 6-4 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/20/2024: 4-2 HOU (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/19/2024: 3-0 HOU (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/30/2024: 4-0 HOU (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -132, Underdog Moneyline: +112)

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