Mariners vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for May 22

Odds updated as of 7:11 p.m.

In MLB action on Thursday, the Seattle Mariners face the Houston Astros.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Mariners vs Astros Game Info

• Seattle Mariners (28-20) vs. Houston Astros (25-24)
• Date: Thursday, May 22, 2025
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and ROOT Sports NW

Mariners vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-134) | HOU: (+114)
• Spread: SEA: -1.5 (+122) | HOU: +1.5 (-146)
• Total: 8.5 -- Over: (-112) | Under: (-108)

Mariners vs Astros Probable Starting Pitchers

Probable Pitchers: George Kirby (Mariners) - 0-0, 0.00 ERA vs Lance McCullers (Astros) - 0-1, 7.88 ERA

This contest's pitching matchup is set, as the Mariners will send George Kirby to the mound, while Lance McCullers (0-1) will take the ball for the Astros. In games Kirby pitched with a spread last season, his team was 15-18-0 ATS. Kirby and his team won as favorites in 52.2% of his 23 appearances last season with a moneyline. The Astros have a 1-2-0 ATS record in McCullers' three starts with a set spread. The Astros were the moneyline underdog for one McCullers start this season -- they won.

Mariners vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (54.6%)

Mariners vs Astros Moneyline

• Seattle is the favorite, -134 on the moneyline, while Houston is a +114 underdog despite being at home.

Mariners vs Astros Spread

• The Mariners are favored by 1.5 runs on the road against the Astros. The Mariners are +122 to cover the spread, while the Astros are -146.

Mariners vs Astros Over/Under

• Mariners versus Astros on May 22 has an over/under of 8.5 runs, with the odds on the over -112 and the under set at -108.

Bet on Seattle Mariners vs. Houston Astros on FanDuel today!

Mariners vs Astros Betting Trends

• The Mariners have been chosen as favorites in 28 games this year and have walked away with the win 17 times (60.7%) in those games.
• This season Seattle has been victorious 13 times in 20 chances when named as a favorite of at least -134 on the moneyline.
• Contests with the Mariners have gone over the total set by bookmakers in 26 of 47 chances this season.
• The Mariners are 24-23-0 against the spread in their 47 games that had a posted line this season.
• The Astros have won seven of the 15 games they were the underdog on the moneyline this season (46.7%).
• Houston has a 3-2 record (winning 60% of its games) when playing as a moneyline underdog of +114 or longer.
• The Astros have had an over/under set by bookmakers 49 times, and have combined with opponents to go over the total in 20 of those games (20-27-2).
• The Astros are 26-23-0 against the spread this season.

Mariners Player Leaders

• Cal Raleigh leads Seattle with 43 hits, batting .249 this season with 26 extra-base hits. He has an on-base percentage of .370 and a slugging percentage of .584.
• Among all qualifying batters in MLB, he ranks 91st in batting average, 33rd in on-base percentage, and fifth in slugging.
• Raleigh will look for his third straight game with a hit in this contest. In his last five games he is batting .235 with two doubles, two home runs, four walks and three RBIs.
• Julio Rodriguez leads Seattle in slugging percentage (.415) thanks to 16 extra-base hits. He's batting .231 with an on-base percentage of .309.
• Among all qualifying players, he ranks 116th in batting average, 106th in on-base percentage and 82nd in slugging percentage.
• Jorge Polanco is batting .298 with a .589 slugging percentage and 30 RBI this year.
• J.P. Crawford has 43 hits this season and a team-best OBP of .391.

Astros Player Leaders

• Isaac Paredes has totaled 48 hits with a .378 on-base percentage, leading the Astros in both statistics. He's batting .270 and slugging .483.
• Including all the qualifying hitters in MLB, his batting average places him 59th, his on-base percentage is 22nd, and he is 36th in slugging.
• Paredes heads into this game on a six-game hitting streak. During his last 10 games he is hitting .289 with six home runs, five walks and 11 RBIs.
• Jeremy Pena's .438 slugging percentage paces his team. He has a batting average of .297 with an on-base percentage of .356.
• His batting average ranks 22nd among all qualified players, his on-base percentage is 48th, and he is 65th in slugging.
• Jake Meyers is hitting .306 with seven doubles, a triple, three home runs and 15 walks.
• Jose Altuve is hitting .238 with six doubles, four home runs and 15 walks.

Mariners vs Astros Head to Head

• 4/9/2025: 7-6 SEA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/8/2025: 2-1 HOU (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/7/2025: 4-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 9/25/2024: 8-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/24/2024: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/23/2024: 6-1 SEA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/21/2024: 6-4 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/20/2024: 4-2 HOU (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/19/2024: 3-0 HOU (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/30/2024: 4-0 HOU (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -132, Underdog Moneyline: +112)

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