Tigers vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for May 21

Odds updated as of 12:12 p.m.

On Thursday in MLB, the Detroit Tigers are up against the Cleveland Guardians.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this game.

Tigers vs Guardians Game Info

• Detroit Tigers (20-30) vs. Cleveland Guardians (29-22)
• Date: Thursday, May 21, 2026
• Time: 1:10 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: DSN and CleGuardians.TV

Tigers vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-120) | CLE: (+102)
• Spread: DET: -1.5 (+172) | CLE: +1.5 (-210)
• Total: 7.5 -- Over: (+102) | Under: (-124)

Tigers vs Guardians Probable Starting Pitchers

Probable Pitchers: Casey Mize (Tigers) - 2-2, 2.43 ERA vs Joey Cantillo (Guardians) - 3-1, 3.40 ERA

The Tigers will give the ball to Casey Mize (2-2, 2.43 ERA), who is eyeing win No. 3 on the season, and the Guardians will turn to Joey Cantillo (3-1, 3.40 ERA). Mize and his team have a record of 4-3-0 against the spread when he starts. Mize's team has won 66.7% of his starts when they are favored on the moneyline (2-1). When Cantillo starts, the Guardians are 8-2-0 against the spread. The Guardians have a 4-1 record in Cantillo's five starts this season when they were the underdog on the moneyline.

Tigers vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (57%)

Tigers vs Guardians Moneyline

• Cleveland is a +102 underdog on the moneyline, while Detroit is a -120 favorite at home.

Tigers vs Guardians Spread

• The Tigers are 1.5-run home favorites on the runline against the Guardians. The Tigers are +172 to cover, and the Guardians are -210.

Tigers vs Guardians Over/Under

• Tigers versus Guardians, on May 21, has an over/under of 7.5, with the over being +102 and the under -124.

Bet on Detroit Tigers vs. Cleveland Guardians on FanDuel today!

Tigers vs Guardians Betting Trends

• The Tigers have won in 13, or 52%, of the 25 contests they have been named as odds-on favorites in this year.
• This season Detroit has been victorious 13 times in 20 chances when named as a favorite of at least -120 on the moneyline.
• Contests with the Tigers have gone over the total set by oddsmakers in 21 of 49 chances this season.
• In 49 games with a line this season, the Tigers have a mark of 25-24-0 against the spread.
• The Guardians have gone 11-10 in games they were the underdog on the moneyline (winning 52.4% of those games).
• Cleveland is 9-9 (winning 50% of its games) when it has played as a moneyline underdog of +102 or longer.
• In the 48 games bookmakers have set an over/under for the Guardians, they have combined with opponents to go over the total 25 times (25-23-0).
• The Guardians are 25-23-0 ATS this season.

Tigers Player Leaders

• Kevin McGonigle has 12 doubles, two triples, two home runs and 30 walks while batting .285. He has an on-base percentage of .393 and a slugging percentage of .408.
• He is 34th in batting average, 12th in on-base percentage, and 83rd in slugging among all qualified hitters in MLB.
• Riley Greene leads Detroit in OBP (.430), slugging percentage (.486) and total hits (59) this season. He's batting .333.
• Among qualifying batters, he is second in batting average, second in on-base percentage and 35th in slugging percentage.
• Greene has picked up at least one hit in three straight games. In his last five games he is hitting .375 with a double, two walks and an RBI.
• Dillon Dingler has collected 37 base hits, an OBP of .313 and a slugging percentage of .443 this season.
• Matt Vierling has four home runs, 20 RBI and a batting average of .207 this season.

Guardians Player Leaders

• Jose Ramirez is hitting .235 with 11 doubles, eight home runs and 37 walks. He's slugging .422 with an on-base percentage of .363.
• Including all qualifying players in the majors, his batting average places him 112th, his on-base percentage is 40th, and he is 74th in slugging.
• Chase DeLauter's .470 slugging percentage paces his team. He has a batting average of .274 with an on-base percentage of .361.
• He ranks 49th in batting average, 41st in on-base percentage and 45th in slugging percentage in the big leagues.
• Brayan Rocchio a has .366 on-base percentage to lead the Guardians.
• Angel Martinez has collected 41 hits to pace his team.

Tigers vs Guardians Head to Head

• 5/20/2026: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/19/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 10/2/2025: 6-3 DET (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 10/1/2025: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/30/2025: 2-1 DET (Favorite: Tigers, Spread: -1.5, Total: 6, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 9/25/2025: 4-2 DET (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 9/23/2025: 5-2 CLE (Favorite: Tigers, Spread: -1.5, Total: 6.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 9/18/2025: 3-1 CLE (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 9/17/2025: 4-0 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/16/2025: 7-5 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)

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