Syracuse vs UConn Prediction, Odds, Picks, Best Bets for Week 2 2025

The college football slate on Saturday includes the Syracuse Orange taking on the UConn Huskies.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Syracuse vs UConn Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Syracuse: (-250) | UConn: (+202)
• Spread: Syracuse: -6.5 (-122) | UConn: +6.5 (100)
• Total: 57.5 -- Over: (-105) | Under: (-115)

Syracuse vs UConn Betting Trends

• Syracuse is winless against the spread this year.
• Syracuse and its opponent have not failed to hit the over in any game this season.
• UConn is unbeaten against the spread this season.
• One of UConn's one games has hit the over.

Syracuse vs UConn Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Orange win (69.6%)

Syracuse vs UConn Point Spread

Syracuse is a 6.5-point favorite against UConn. Syracuse is -122 to cover the spread, and UConn is +100.

Syracuse vs UConn Over/Under

A total of 57.5 points has been set for the Syracuse-UConn matchup on Sept. 6, with the over available at -105 and the under at -115.

Syracuse vs UConn Moneyline

Syracuse is the favorite, -250 on the moneyline, while UConn is a +202 underdog.

Syracuse vs. UConn Points Insights

• The Orange's average implied point total last season was 1.4 more points than their implied total in Saturday's game (33.4 implied points on average compared to 32 implied points in this game).
• The Huskies' average implied point total last season (29.3 points) is 3.3 points higher than their implied total in this matchup (26 points).

Syracuse vs. UConn Game Info

• Game day: Saturday, September 6, 2025
• Game time: 12 p.m. ET
• TV channel: ACC Network Extra
• Location: Syracuse, New York
• Stadium: JMA Wireless Dome

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Check out even more in-depth Syracuse vs. UConn analysis on FanDuel Research.