Reds vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for May 19

Odds updated as of 6:11 p.m.

The Monday slate in MLB includes a matchup between the Cincinnati Reds and the Pittsburgh Pirates.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Reds vs Pirates Game Info

• Cincinnati Reds (24-24) vs. Pittsburgh Pirates (15-32)
• Date: Monday, May 19, 2025
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: Fox Sports 1, SportsNet PT, and FDSOH

Reds vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-116) | PIT: (-102)
• Spread: CIN: -1.5 (+146) | PIT: +1.5 (-176)
• Total: 8 -- Over: (-120) | Under: (-102)

Reds vs Pirates Probable Starting Pitchers

Probable Pitchers: Nick Lodolo (Reds) - 3-4, 3.42 ERA vs Mitch Keller (Pirates) - 1-5, 4.15 ERA

The Reds will give the nod to Nick Lodolo (3-4) versus the Pirates and Mitch Keller (1-5). Lodolo and his team are 5-4-0 ATS this season when he starts. Lodolo's team has won 40% of his starts when they are favored on the moneyline (2-3). When Keller starts, the Pirates are 3-6-0 against the spread. The Pirates have been the moneyline underdog in six of Keller's starts this season, and they went 1-5 in those matchups.

Reds vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (57.8%)

Reds vs Pirates Moneyline

• The Reds vs Pirates moneyline has Cincinnati as a -116 favorite, while Pittsburgh is a -102 underdog at home.

Reds vs Pirates Spread

• The Pirates are +1.5 on the spread (-176 to cover), and Cincinnati is +146 to cover the runline.

Reds vs Pirates Over/Under

• The Reds-Pirates game on May 19 has been given an over/under of 8 runs. The over is set at -120 and the under at -102.

Bet on Cincinnati Reds vs. Pittsburgh Pirates on FanDuel today!

Reds vs Pirates Betting Trends

• The Reds have come away with 11 wins in the 19 contests they have been listed as the favorites in this season.
• Cincinnati has a record of 10-8 when favored by -116 or more this year.
• The Reds and their opponents have gone over the total this season in 18 of their 46 opportunities.
• The Reds are 25-21-0 against the spread in their 46 games with a line set by sportsbooks this season.
• The Pirates have won 10 of the 30 games they were the moneyline underdog this season (33.3%).
• When playing as a moneyline underdog with odds of -102 or longer, Pittsburgh has an 8-19 record (winning only 29.6% of its games).
• The Pirates have played in 45 games with an over/under set, and have combined with their opponents to go over the total 17 times (17-26-2).
• The Pirates have put together an 18-27-0 record against the spread this season (covering 40% of the time).

Reds Player Leaders

• Elly De La Cruz leads Cincinnati with 46 hits and a team-best slugging percentage of .406. He's batting .246 with an on-base percentage of .317.
• Among qualified batters in the majors, his batting average ranks 99th, his on-base percentage ranks 101st, and he is 90th in slugging.
• TJ Friedl is batting .265 with seven doubles, a triple, three home runs and 23 walks, while slugging .373 with an on-base percentage of .358.
• He is 60th in batting average, 46th in on-base percentage and 116th in slugging in the majors.
• Gavin Lux leads Cincinnati in OBP (.379) this season, fueled by 43 hits.
• Austin Hays has been key for Cincinnati with 26 hits, an OBP of .363 plus a slugging percentage of .590.
• Hays takes a five-game hitting streak into this game. During his last five outings he is batting .333 with two doubles, a home run, a walk and four RBIs.

Pirates Player Leaders

• Oneil Cruz has racked up 31 hits, a team-best for the Pirates. He's batting .223 and slugging .432 with an on-base percentage of .349.
• Including all qualifying players in the big leagues, he ranks 129th in batting average, 57th in on-base percentage and 70th in slugging percentage.
• Andrew McCutchen is hitting .248 with seven doubles, three home runs and 20 walks. He's slugging .368 with an on-base percentage of .348.
• He is 94th in batting average, 61st in on-base percentage and 121st in slugging percentage in the big leagues.
• Bryan Reynolds is hitting .203 with five doubles, six home runs and 16 walks.
• Isiah Kiner-Falefa is hitting .279 with three doubles, a triple, a home run and eight walks.

Reds vs Pirates Head to Head

• 4/13/2025: 4-0 CIN (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 4/12/2025: 5-2 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/11/2025: 5-3 CIN (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 9/22/2024: 2-0 PIT (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/21/2024: 7-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/20/2024: 8-3 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/25/2024: 4-3 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 8/24/2024: 10-2 CIN (Favorite: Pirates, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 8/23/2024: 6-5 PIT (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/22/2024: 7-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!