Reds vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for April 16

Odds updated as of 12:11 p.m.

MLB action on Thursday includes the Cincinnati Reds facing the San Francisco Giants.

We've got you covered, in terms of the vital information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Reds vs Giants Game Info

• Cincinnati Reds (11-7) vs. San Francisco Giants (6-12)
• Date: Thursday, April 16, 2026
• Time: 12:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: Reds.TV and NBCS-BA

Reds vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-130) | SF: (+110)
• Spread: CIN: -1.5 (+164) | SF: +1.5 (-200)
• Total: 8 -- Over: (-118) | Under: (-104)

Reds vs Giants Probable Starting Pitchers

Probable Pitchers: Chase Burns (Reds) - 1-1, 3.31 ERA vs Landen Roupp (Giants) - 2-1, 3.24 ERA

The Reds will look to Chase Burns (1-1) versus the Giants and Landen Roupp (2-1). Burns and his team have a record of 1-2-0 against the spread when he starts. Burns' team is 1-1 this season when he starts and they're favored on the moneyline. The Giants have gone 1-2-0 against the spread when Roupp starts. The Giants were the moneyline underdog for two Roupp starts this season -- they won both.

Reds vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (53.6%)

Reds vs Giants Moneyline

• The moneyline numbers for Reds vs. Giants reveal Cincinnati as the favorite (-130) and San Francisco as the underdog (+110) on the road.

Reds vs Giants Spread

• The Reds are favored by 1.5 runs at home against the Giants. The Reds are +164 to cover the spread, while the Giants are -200.

Reds vs Giants Over/Under

• An over/under of 8 has been set for Reds-Giants on April 16, with the over being -118 and the under -104.

Bet on Cincinnati Reds vs. San Francisco Giants on FanDuel today!

Reds vs Giants Betting Trends

• The Reds have come away with three wins in the four contests they have been listed as the favorites in this season.
• Cincinnati has a record of 2-1 in contests when sportsbooks favor them by -130 or more on the moneyline.
• The Reds' games have gone over the total in 10 of their 18 opportunities.
• The Reds are 10-8-0 against the spread in their 18 games that had a posted line this season.
• The Giants have won five of the 13 games they were listed as the moneyline underdog this season (38.5%).
• San Francisco has a 2-3 record (winning 40% of its games) when it has played as a moneyline underdog of +110 or longer.
• The Giants have had an over/under set by oddsmakers 18 times, and have combined with opponents to go over the total in eight of those games (8-7-3).
• The Giants have put together a 5-13-0 record ATS this season (covering just 27.8% of the time).

Reds Player Leaders

• Sal Stewart has 20 hits and an OBP of .434 to go with a slugging percentage of .726. All three of those stats are best among Cincinnati hitters this season. He has a .323 batting average, as well.
• Among qualified hitters in MLB, his batting average ranks 16th, his on-base percentage ranks ninth, and he is second in slugging.
• Stewart hopes to build on a three-game hitting streak in this matchup. During his last five outings he is hitting .222 with three home runs, three walks and eight RBIs.
• Elly De La Cruz has hit six homers this season while driving in 11 runs. He's batting .282 this season and slugging .577 with an on-base percentage of .363.
• He is 51st in batting average, 53rd in on-base percentage and 13th in slugging in MLB.
• De La Cruz has picked up at least one hit in six games in a row. During his last 10 games he is hitting .333 with three doubles, three home runs, six walks and seven RBIs.
• Eugenio Suarez has 16 hits this season and has a slash line of .250/.324/.406.
• Matt McLain is batting .203 with a .354 OBP and three RBI for Cincinnati this season.

Giants Player Leaders

• Luis Arraez has a .371 on-base percentage and a .413 slugging percentage, both team-best marks for the Giants. He's batting .333.
• Including all the qualifying hitters in the majors, his batting average is seventh, his on-base percentage is 43rd, and he is 79th in slugging.
• Arraez brings a three-game hitting streak into this game. In his last five games he is hitting .467 with a triple and four walks.
• Willy Adames leads his team with 18 hits. He has a batting average of .257 while slugging .514 with an on-base percentage of .307.
• His batting average ranks 74th among all qualified players, his on-base percentage is 121st, and he is 36th in slugging.
• Matt Chapman is hitting .271 with three doubles, a triple, a home run and five walks.
• Jung Hoo Lee is hitting .213 with six doubles, a home run and six walks.

Reds vs Giants Head to Head

• 4/15/2026: 8-3 CIN (Favorite: Giants, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/14/2026: 2-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/9/2025: 8-6 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/8/2025: 1-0 CIN (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/7/2025: 2-0 CIN (Favorite: Giants, Spread: -1.5, Total: 6.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 3/30/2025: 6-3 SF (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 3/29/2025: 3-2 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 3/27/2025: 6-4 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/4/2024: 8-2 SF (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/3/2024: 6-4 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)

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