Reds vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for April 15

Odds updated as of 6:13 p.m.

MLB action on Wednesday includes the San Francisco Giants facing the Cincinnati Reds.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Giants vs Reds Game Info

• San Francisco Giants (6-11) vs. Cincinnati Reds (10-7)
• Date: Wednesday, April 15, 2026
• Time: 6:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: Reds.TV and NBCS-BA

Giants vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-110) | CIN: (-106)
• Spread: SF: -1.5 (+142) | CIN: +1.5 (-172)
• Total: 9 -- Over: (-115) | Under: (-105)

Giants vs Reds Probable Starting Pitchers

Probable Pitchers: Tyler Mahle (Giants) - 0-2, 4.30 ERA vs Rhett Lowder (Reds) - 1-1, 3.31 ERA

The Giants will give the ball to Tyler Mahle (0-2, 4.30 ERA), who is eyeing win No. 1 on the season, and the Reds will turn to Rhett Lowder (1-1, 3.31 ERA). Mahle and his team have a record of 1-2-0 against the spread when he starts. Mahle has yet to start a game this season when his team was the moneyline favorite. The Reds have gone 2-1-0 against the spread when Lowder starts. The Reds are 2-1 in Lowder's three starts this season that they were the moneyline underdog.

Giants vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (52%)

Giants vs Reds Moneyline

• San Francisco is the favorite, -110 on the moneyline, while Cincinnati is a -106 underdog despite being at home.

Giants vs Reds Spread

• The Reds are +1.5 on the spread (-172 to cover), and San Francisco is +142 to cover the runline.

Giants vs Reds Over/Under

• A combined run total of 9 has been set for Giants-Reds on April 15, with the over at -115 and the under at -105.

Bet on San Francisco Giants vs. Cincinnati Reds on FanDuel today!

Giants vs Reds Betting Trends

• The Giants have come away with one wins in the four contests they have been listed as the favorites in this season.
• This season San Francisco has been victorious one time in four chances when named as a favorite of at least -110 on the moneyline.
• The Giants and their opponents have gone over in seven of their 17 games with a total set by sportsbooks this season.
• The Giants are 5-12-0 against the spread in their 17 games that had a posted line this season.
• The Reds have won seven of the 12 games they were listed as the moneyline underdog this season (58.3%).
• In games it has played as a moneyline underdog with odds of -106 or longer, Cincinnati has a 7-5 record (winning 58.3% of its games).
• The Reds have combined with opponents to go over the total nine times this season for a 9-7-1 record against the over/under.
• The Reds have collected a 9-8-0 record against the spread this season.

Giants Player Leaders

• Willy Adames has 18 hits, which leads San Francisco hitters this season, while batting .273 with 12 extra-base hits. He has an on-base percentage of .324 and a slugging percentage of .545.
• He is 60th in batting average, 101st in on-base percentage, and 26th in slugging among qualified hitters in MLB.
• Adames hopes to build on a two-game hitting streak in this matchup. In his last five games he is batting .350 with three doubles, two home runs, a walk and three RBIs.
• Luis Arraez leads the Giants with an OPS of .780. He has a slash line of .333/.364/.417 this season.
• He is eighth in batting average, 52nd in on-base percentage and 76th in slugging in MLB.
• Arraez takes a two-game streak with at least one hit into this contest. In his last five games he is batting .438 with a triple, three walks and two RBIs.
• Matt Chapman has collected 18 base hits, an OBP of .324 and a slugging percentage of .394 this season.
• Jung Hoo Lee has been key for San Francisco with 12 hits, an OBP of .262 plus a slugging percentage of .345.

Reds Player Leaders

• Sal Stewart has accumulated a team-high OBP (.431), while pacing the Reds in hits (18). He's batting .310 and slugging.
• Including all qualifying hitters, he ranks 26th in batting average, while his on-base percentage is 10th and he is seventh in slugging.
• Elly De La Cruz is slugging .552 to lead his team. He has a batting average of .284 with an on-base percentage of .360.
• Including all qualified players, he is 53rd in batting average, 58th in on-base percentage and 23rd in slugging percentage.
• Matt McLain is batting .210 with three doubles and 10 walks.
• Spencer Steer has three doubles, three home runs and three walks while batting .185.

Giants vs Reds Head to Head

• 4/14/2026: 2-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/9/2025: 8-6 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/8/2025: 1-0 CIN (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/7/2025: 2-0 CIN (Favorite: Giants, Spread: -1.5, Total: 6.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 3/30/2025: 6-3 SF (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 3/29/2025: 3-2 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 3/27/2025: 6-4 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/4/2024: 8-2 SF (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/3/2024: 6-4 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/12/2024: 6-5 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)

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