Reds vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for April 28

Odds updated as of 6:11 p.m.

Monday's slate in the MLB includes a matchup between the Cincinnati Reds and the St. Louis Cardinals.

We've got you covered, in terms of the most important info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Reds vs Cardinals Game Info

• Cincinnati Reds (15-13) vs. St. Louis Cardinals (12-16)
• Date: Monday, April 28, 2025
• Time: 6:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: MLB Network, FDSOH, and FDSMW

Reds vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-120) | STL: (+102)
• Spread: CIN: +1.5 (-192) | STL: -1.5 (+158)
• Total: 9.5 -- Over: (-102) | Under: (-120)

Reds vs Cardinals Probable Starting Pitchers

Probable Pitchers: Nick Martínez (Reds) - 0-3, 5.40 ERA vs Andre Pallante (Cardinals) - 2-1, 4.05 ERA

The probable pitchers are Nick Martinez (0-3) for the Reds and Andre Pallante (2-1) for the Cardinals. When Martinez starts, his team is 1-4-0 against the spread this season. Martinez's team lost his only start as a favorite this season. The Cardinals have gone 3-2-0 ATS in Pallante's five starts that had a set spread. The Cardinals have been the underdog on the moneyline in five of Pallante's starts this season, and they went 3-2 in those matchups.

Reds vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (53.6%)

Reds vs Cardinals Moneyline

• Cincinnati is a -120 favorite on the moneyline, while St. Louis is a +102 underdog on the road.

Reds vs Cardinals Spread

• The Cardinals are 1.5-run favorites against the spread for this matchup with the Reds. The Cardinals are +158 to cover, while the Reds are -192 to cover as a 1.5-run underdog on the runline.

Reds vs Cardinals Over/Under

• The over/under for Reds-Cardinals on April 28 is 9.5. The over is -102, and the under is -120.

Bet on Cincinnati Reds vs. St. Louis Cardinals on FanDuel today!

Reds vs Cardinals Betting Trends

• The Reds have been chosen as favorites in 12 games this year and have walked away with the win eight times (66.7%) in those games.
• This season Cincinnati has been victorious six times in eight chances when named as a favorite of at least -120 on the moneyline.
• Contests with the Reds have gone over the total set by oddsmakers in 13 of 28 chances this season.
• The Reds are 16-12-0 against the spread in their 28 games that had a posted line this season.
• The Cardinals are 8-11 in games they were the underdog on the moneyline (winning 42.1% of those games).
• St. Louis has a record of 3-9 when playing as a moneyline underdog with odds of +102 or longer (25%).
• The Cardinals have played in 28 games with an over/under set, and have combined with opponents to go over the total 15 times (15-11-2).
• The Cardinals have a 12-16-0 record against the spread this season (covering 42.9% of the time).

Reds Player Leaders

• Elly De La Cruz is batting .270 with three doubles, five home runs and 12 walks. He has an on-base percentage of .339 and a slugging percentage of .432.
• Among all qualified batters in MLB, he ranks 56th in batting average, 61st in on-base percentage, and 58th in slugging.
• De La Cruz has recorded a base hit in 11 games in a row. During his last 10 outings he is hitting .341 with two home runs, six walks and six RBI.
• TJ Friedl has hit one homers this season while driving in 12 runs. He's batting .294 this season and slugging .394 with an on-base percentage of .350.
• Among qualified hitters, he ranks 25th in batting average, 51st in on-base percentage and 85th in slugging percentage.
• Friedl brings a two-game streak with at least one hit into this matchup. During his last five outings he is batting .292 with three doubles, a walk and two RBI.
• Austin Hays has 19 hits this season and has a slash line of .388/.444/.755.
• Hays has recorded a hit in three games in a row. During his last five outings he is batting .353 with two doubles, two home runs, three walks and four RBI.
• Noelvi Marte is batting .364 with a .404 OBP and 15 RBI for Cincinnati this season.
• Marte brings a three-game hitting streak into this game. In his last five games he is hitting .381 with a double, two home runs, two walks and eight RBI.

Cardinals Player Leaders

• Lars Nootbaar has accumulated a team-best .409 on-base percentage. He's batting .272 and slugging .427.
• Including all the qualifying hitters in the majors, his batting average ranks 49th, his on-base percentage is 12th, and he is 62nd in slugging.
• Nootbaar hopes to build on a three-game hitting streak in this matchup. In his last five games he is batting .421 with a double, a home run, six walks and six RBI.
• Brendan Donovan has racked up 37 hits while slugging .534. Both lead his team. He has a batting average of .359 with an on-base percentage of .396.
• Including all qualified players, he ranks third in batting average, 17th in on-base percentage and 21st in slugging percentage.
• Nolan James Arenado is hitting .255 with eight doubles, three home runs and 14 walks.
• Victor Scott II has five doubles, a triple, a home run and eight walks while batting .264.

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