Red Sox vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for May 25

Odds updated as of 4:15 a.m.

The MLB's Sunday slate includes the Boston Red Sox taking on the Baltimore Orioles.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Red Sox vs Orioles Game Info

• Boston Red Sox (27-27) vs. Baltimore Orioles (17-34)
• Date: Sunday, May 25, 2025
• Time: 1:35 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: MLB Network, NESN, and MASN

Red Sox vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-130) | BAL: (+110)
• Spread: BOS: -1.5 (+146) | BAL: +1.5 (-176)
• Total: 9.5 -- Over: (-105) | Under: (-115)

Red Sox vs Orioles Probable Starting Pitchers

Probable Pitchers: Walker Buehler (Red Sox) - 4-1, 4.00 ERA vs Dean Kremer (Orioles) - 3-5, 5.50 ERA

This contest's pitching matchup is set, as the Red Sox will send Walker Buehler (4-1) to the mound, while Dean Kremer (3-5) will take the ball for the Orioles. Buehler and his team have a record of 5-2-0 against the spread when he starts. Buehler's team has won each of the four games he's started as the moneyline favorite. The Orioles have gone 3-7-0 ATS in Kremer's 10 starts with a set spread. The Orioles are 1-4 in Kremer's five starts this season that they were the underdog on the moneyline.

Red Sox vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (51.3%)

Red Sox vs Orioles Moneyline

• Baltimore is the underdog, +110 on the moneyline, while Boston is a -130 favorite at home.

Red Sox vs Orioles Spread

• The Red Sox are hosting the Orioles and are favored by 1.5 runs (+146 to cover) on the runline. Baltimore is -176 to cover.

Red Sox vs Orioles Over/Under

• A total of 9.5 runs has been set for the Red Sox-Orioles game on May 25, with the over available at -105 and the under at -115.

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Red Sox vs Orioles Betting Trends

• The Red Sox have been victorious in 19, or 50%, of the 38 contests they have been chosen as favorites in this season.
• This season Boston has been victorious eight times in 18 chances when named as a favorite of at least -130 on the moneyline.
• The Red Sox's games have gone over the total in 26 of their 54 opportunities.
• The Red Sox are 28-26-0 against the spread in their 54 games that had a posted line this season.
• The Orioles have been the underdog on the moneyline 22 total times this season. They've finished 8-14 in those games.
• Baltimore has a 1-7 record (winning only 12.5% of its games) when it has played as a moneyline underdog of +110 or longer.
• The Orioles have had an over/under set by bookmakers 51 times, and have combined with opponents to go over the total in 26 of those games (26-23-2).
• The Orioles have put together a 16-35-0 record ATS this season (covering just 31.4% of the time).

Red Sox Player Leaders

• Rafael Devers leads Boston with an OBP of .412 this season while batting .297 with 40 walks and 35 runs scored. He has a slugging percentage of .550.
• Among all qualified batters in MLB, he is 19th in batting average, fifth in on-base percentage, and 11th in slugging.
• Jarren Duran has an OPS of .744, fueled by an OBP of .319 and a team-best slugging percentage of .425 this season. He's batting .268.
• Among qualifying hitters, his batting average places him 64th, his on-base percentage 99th, and his slugging percentage 76th.
• Wilyer Abreu is batting .262 with a .517 slugging percentage and 28 RBI this year.
• Abreu enters this game with two games in a row with at least one hit. In his last five games he is batting .235 with a double, a home run, a walk and an RBI.
• Ceddanne Rafaela is batting .226 with a .281 OBP and 19 RBI for Boston this season.

Orioles Player Leaders

• Cedric Mullins has nine doubles, 10 home runs and 23 walks while batting .225. He's slugging .451 with an on-base percentage of .322.
• Including all qualified hitters, he ranks 136th in batting average, while his on-base percentage is 92nd and he is 59th in slugging.
• Ryan O'Hearn has racked up 46 hits with a .405 on-base percentage to lead his team in both. He has a batting average of .315 while slugging .500.
• Including all qualified hitters, he ranks 10th in batting average, sixth in on-base percentage and 28th in slugging percentage.
• Adley Rutschman has seven doubles, a triple, five home runs and 24 walks while batting .214.
• Gunnar Henderson is slugging .458 to lead his team.

Red Sox vs Orioles Head to Head

• 5/24/2025: 2-1 BAL (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 5/24/2025: 6-5 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/23/2025: 19-5 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/3/2025: 8-4 BOS (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/2/2025: 3-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 3/31/2025: 8-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/11/2024: 5-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/10/2024: 5-3 BAL (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/9/2024: 12-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/18/2024: 4-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -122, Underdog Moneyline: +104)

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