Phillies vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for May 11

Odds updated as of 5:12 p.m.

The Sunday schedule in MLB includes a matchup between the Philadelphia Phillies and the Cleveland Guardians.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this matchup.

Phillies vs Guardians Game Info

• Philadelphia Phillies (23-16) vs. Cleveland Guardians (23-16)
• Date: Sunday, May 11, 2025
• Time: 7:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: ESPN

Phillies vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PHI: (-172) | CLE: (+144)
• Spread: PHI: -1.5 (+102) | CLE: +1.5 (-122)
• Total: 7.5 -- Over: (+102) | Under: (-124)

Phillies vs Guardians Probable Starting Pitchers

Probable Pitchers: Zack Wheeler (Phillies) - 3-1, 3.35 ERA vs Luis Ortiz (Guardians) - 2-3, 5.30 ERA

This contest's pitching matchup is set, as the Phillies will send Zack Wheeler (3-1) to the mound, while Luis Ortiz (2-3) will take the ball for the Guardians. Wheeler and his team are 4-4-0 ATS this season when he starts. Wheeler's team has been victorious in 71.4% of the games he's started as the moneyline favorite with a record of 5-2. When Ortiz starts, the Guardians have gone 3-4-0 against the spread. The Guardians have been the underdog on the moneyline in three of Ortiz's starts this season, and they went 1-2 in those matchups.

Phillies vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Phillies win (58.2%)

Phillies vs Guardians Moneyline

• The moneyline numbers for Phillies vs. Guardians reveal Philadelphia as the favorite (-172) and Cleveland as the underdog (+144) despite being the home team.

Phillies vs Guardians Spread

• The Guardians are +1.5 on the spread (-122 to cover), and Philadelphia is +102 to cover the runline.

Phillies vs Guardians Over/Under

• A total of 7.5 runs has been set for the Phillies-Guardians contest on May 11, with the over available at +102 and the under at -124.

Bet on Philadelphia Phillies vs. Cleveland Guardians on FanDuel today!

Phillies vs Guardians Betting Trends

• The Phillies have won in 19, or 61.3%, of the 31 contests they have been named as odds-on favorites in this year.
• This season Philadelphia has come away with a win nine times in 11 chances when named as a favorite of at least -172 on the moneyline.
• The Phillies' games have gone over the total in 18 of their 38 opportunities.
• The Phillies have posted a record of 20-18-0 against the spread this season.
• The Guardians have been the underdog on the moneyline 23 total times this season. They've finished 11-12 in those games.
• Cleveland has played as a moneyline underdog of +144 or longer in just two games this season, which it lost both.
• The Guardians have had an over/under set by bookmakers 38 times, and have combined with opponents to go over the total in 21 of those games (21-15-2).
• The Guardians have an 18-20-0 record ATS this season (covering 47.4% of the time).

Phillies Player Leaders

• Kyle Schwarber leads Philadelphia in OBP (.402) and total hits (37) this season. He's batting .262 batting average while slugging .553.
• Among all qualifying hitters in the majors, he ranks 68th in batting average, eighth in on-base percentage, and eighth in slugging.
• Bryce Harper has eight doubles, seven home runs and 27 walks. He's batting .242 and slugging .436 with an on-base percentage of .356.
• He is 99th in batting average, 46th in on-base percentage and 62nd in slugging in the majors.
• Trea Turner has hit two homers with a team-high .404 SLG this season.
• Turner enters this matchup with nine games in a row with at least one hit. During his last 10 outings he is batting .386 with two doubles, a home run, two walks and three RBIs.
• Bryson Stott has been key for Philadelphia with 36 hits, an OBP of .327 plus a slugging percentage of .391.

Guardians Player Leaders

• Steven Kwan has accumulated a .391 on-base percentage and a .451 slugging percentage, both team-best marks for the Guardians. He's batting .327.
• Including all the qualified hitters in MLB, his batting average is fourth, his on-base percentage ranks 13th, and he is 54th in slugging.
• Jose Ramirez has eight doubles, six home runs and 13 walks while hitting .287. He's slugging .478 with an on-base percentage of .348.
• His batting average is 34th among all qualified players, his on-base percentage is 58th, and he is 35th in slugging.
• Kyle Manzardo has racked up 25 hits, a team-high for the Guardians.
• Carlos Santana has three doubles, four home runs and 16 walks while hitting .231.

Phillies vs Guardians Head to Head

• 5/10/2025: 7-1 PHI (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/9/2025: 6-0 CLE (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/28/2024: 4-3 CLE (Favorite: Phillies, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/27/2024: 8-0 PHI (Favorite: Phillies, Spread: -1.5, Total: 9.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 7/26/2024: 3-1 CLE (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 7/23/2023: 8-5 PHI (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/22/2023: 1-0 CLE (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/21/2023: 6-5 CLE (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)

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