Phillies vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for May 10

Odds updated as of 6:11 p.m.

The Philadelphia Phillies will take on the Cleveland Guardians in MLB action on Saturday.

We've got you covered, in terms of the most important info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Phillies vs Guardians Game Info

• Philadelphia Phillies (22-16) vs. Cleveland Guardians (23-15)
• Date: Saturday, May 10, 2025
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and NBCS-PH

Phillies vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PHI: (-132) | CLE: (+112)
• Spread: PHI: -1.5 (+126) | CLE: +1.5 (-152)
• Total: 8 -- Over: (-106) | Under: (-114)

Phillies vs Guardians Probable Starting Pitchers

Probable Pitchers: Ranger Suarez (Phillies) - 0-0, 17.18 ERA vs Tanner Bibee (Guardians) - 3-2, 4.26 ERA

The Phillies will give the nod to Ranger Suarez and the Guardians will turn to Tanner Bibee (3-2, 4.26 ERA). Suarez and his team failed to cover the spread in his only opportunity this season as a starter. Suarez's team lost his only start as a favorite this season. The Guardians have a 3-3-0 ATS record in Bibee's six starts with a set spread. The Guardians were the underdog on the moneyline for two Bibee starts this season -- they split the games.

Phillies vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Phillies win (56.6%)

Phillies vs Guardians Moneyline

• Philadelphia is the favorite, -132 on the moneyline, while Cleveland is a +112 underdog despite being at home.

Phillies vs Guardians Spread

• The Guardians are hosting the Phillies, and are +1.5 on the runline. The Guardians are +126 to cover the spread, and the Phillies are -152.

Phillies vs Guardians Over/Under

• Phillies versus Guardians on May 10 has an over/under of 8 runs, with the odds on the over -106 and the under set at -114.

Bet on Philadelphia Phillies vs. Cleveland Guardians on FanDuel today!

Phillies vs Guardians Betting Trends

• The Phillies have won in 18, or 60%, of the 30 contests they have been named as odds-on favorites in this year.
• Philadelphia has a record of 15-6 when favored by -132 or more this year.
• The Phillies and their opponents have hit the over in 18 of their 37 games with a total set by oddsmakers this season.
• The Phillies have posted a record of 19-18-0 against the spread this season.
• The Guardians have compiled an 11-11 record in games they were the underdog on the moneyline (winning 50% of those games).
• Cleveland is 4-5 (winning 44.4% of its games) when playing as a moneyline underdog of +112 or longer.
• The Guardians have combined with opponents to go over the total 21 times this season for a 21-15-1 record against the over/under.
• The Guardians have put together an 18-19-0 record ATS this season (covering 48.6% of the time).

Phillies Player Leaders

• Kyle Schwarber leads Philadelphia in OBP (.402) and total hits (35) this season. He's batting .257 batting average while slugging .559.
• Among the qualifying hitters in MLB, his batting average ranks 71st, his on-base percentage ranks ninth, and he is eighth in slugging.
• Bryce Harper is hitting .229 with seven doubles, six home runs and 27 walks, while slugging .403 with an on-base percentage of .349.
• Among all qualifying hitters, he ranks 112th in batting average, 55th in on-base percentage and 89th in slugging percentage.
• Trea Turner has an OPS of .783, fueled by an OBP of .379 and a team-best slugging percentage of .404 this season.
• Turner takes an eight-game hitting streak into this game. During his last 10 games he is batting .442 with three doubles, a home run, two walks and four RBIs.
• Bryson Stott is batting .271 with a .338 OBP and 20 RBI for Philadelphia this season.

Guardians Player Leaders

• Steven Kwan has accumulated a .394 on-base percentage and a .460 slugging percentage, both team-high numbers for the Guardians. He's batting .333.
• He ranks fourth in batting average, 12th in on-base percentage and 49th in slugging percentage among all qualified hitters in the majors.
• Kwan takes a seven-game hitting streak into this game. In his last 10 games he is hitting .300 with two doubles, six walks and two RBIs.
• Jose Ramirez is hitting .278 with seven doubles, six home runs and 12 walks. He's slugging .466 with an on-base percentage of .338.
• His batting average ranks 45th among all qualified players, his on-base percentage is 67th, and he is 46th in slugging.
• Kyle Manzardo has 25 hits, a team-best for the Guardians.
• Carlos Santana is hitting .229 with three doubles, four home runs and 16 walks.

Phillies vs Guardians Head to Head

• 5/9/2025: 6-0 CLE (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/28/2024: 4-3 CLE (Favorite: Phillies, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/27/2024: 8-0 PHI (Favorite: Phillies, Spread: -1.5, Total: 9.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 7/26/2024: 3-1 CLE (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 7/23/2023: 8-5 PHI (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/22/2023: 1-0 CLE (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/21/2023: 6-5 CLE (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)

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