Padres vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 8:13 p.m.

MLB action on Saturday includes the San Diego Padres taking on the Chicago White Sox.

We've got you covered, in terms of the most important information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Padres vs White Sox Game Info

• San Diego Padres (88-66) vs. Chicago White Sox (36-118)
• Date: Saturday, September 21, 2024
• Time: 8:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: NBCS-CHI

Padres vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-320) | CHW: (+260)
• Spread: SD: -1.5 (-142) | CHW: +1.5 (+118)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Padres vs White Sox Probable Starting Pitchers

Probable Pitchers: Martín Pérez (Padres) - 4-5, 4.36 ERA vs Chris Flexen (White Sox) - 2-14, 5.09 ERA

The probable starters are Martin Perez (4-5) for the Padres and Chris Flexen (2-14) for the White Sox. Pérez's team is 11-12-0 against the spread in his starts this season. Perez's team is 5-5 this season when he starts and they are the moneyline favorite. When Flexen starts, the White Sox have gone 7-21-0 against the spread. The White Sox are 4-24 in Flexen's 28 starts this season that they were the moneyline underdog.

Padres vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (64.8%)

Padres vs White Sox Moneyline

• The Padres vs White Sox moneyline has San Diego as a -320 favorite, while Chicago is a +260 underdog on the road.

Padres vs White Sox Spread

• The White Sox are at +1.5 on the runline against the Padres. The White Sox are +118 to cover the spread, and the Padres are -142.

Padres vs White Sox Over/Under

• An over/under of 7.5 has been set for Padres-White Sox on Sept. 21, with the over being -115 and the under -105.

Bet on San Diego Padres vs. Chicago White Sox on FanDuel today!

Padres vs White Sox Betting Trends

• The Padres have been favorites in 96 games this season and have come away with the win 55 times (57.3%) in those contests.
• These are the best odds of a victory sportsbooks have given San Diego this season, with a -320 moneyline set for this game.
• Contests with the Padres have gone over the total set by bookmakers in 80 of 152 chances this season.
• In 152 games with a line this season, the Padres have a mark of 76-76-0 against the spread.
• The White Sox have won 29 of the 141 games they were the underdog on the moneyline this season (20.6%).
• Chicago is 2-5 (winning only 28.6% of its games) when it has played as a moneyline underdog of +260 or longer.
• The White Sox have combined with opponents to go over the total 66 times this season for a 66-78-5 record against the over/under.
• The White Sox have collected a 60-89-0 record against the spread this season.

Padres Player Leaders

• Jurickson Profar leads San Diego in OBP (.384) this season, fueled by 152 hits. He has a .283 batting average and a slugging percentage of .461.
• Among qualified hitters, he ranks 21st in batting average, his on-base percentage ranks seventh, and he is 40th in slugging.
• Manny Machado is batting .279 with 29 doubles, 29 home runs and 42 walks, while slugging .484 with an on-base percentage of .328.
• Among all qualified hitters, he ranks 26th in batting average, 60th in on-base percentage and 23rd in slugging percentage.
• Machado brings a four-game streak with at least one hit into this contest. During his last five outings he is hitting .350 with a double, three home runs and six RBI.
• Jackson Merrill has 155 hits and is batting .292 this season.
• Merrill heads into this matchup with two games in a row with at least one hit. In his last five games he is batting .333 with two doubles, a home run, two walks and three RBI.
• Luis Arraez leads San Diego in slugging percentage (.390) thanks to 34 extra-base hits.

White Sox Player Leaders

• Andrew Vaughn has racked up 133 hits with a .413 slugging percentage, both team-best stats for the White Sox. He's batting .247 and with an on-base percentage of .299.
• He is 79th in batting average, 112th in on-base percentage and 78th in slugging percentage among all qualifying hitters in the big leagues.
• Vaughn heads into this matchup on a six-game hitting streak. During his last 10 outings he is hitting .333 with two doubles, a triple, two home runs, a walk and five RBI.
• Andrew Benintendi is hitting .226 with 19 doubles, 19 home runs and 41 walks. He's slugging .393 with an on-base percentage of .289.
• He is 119th in batting average, 121st in on-base percentage and 98th in slugging percentage in the big leagues.
• Gavin Sheets has racked up a team-best .308 on-base percentage.
• Nicky Lopez has 12 doubles, three triples, a home run and 37 walks while hitting .243.

Padres vs White Sox Head to Head

• 9/20/2024: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -295, Underdog Moneyline: +240)
• 10/1/2023: 2-1 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 9/30/2023: 6-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/29/2023: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 10/2/2022: 2-1 CHW (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 10/1/2022: 5-2 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/30/2022: 3-1 CHW (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -230, Underdog Moneyline: +190)

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