Padres vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 19

Odds updated as of 7:11 p.m.

On Friday in MLB, the San Diego Padres are up against the Chicago White Sox.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs White Sox Game Info

• San Diego Padres (83-70) vs. Chicago White Sox (57-96)
• Date: Friday, September 19, 2025
• Time: 7:40 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and SDPA

Padres vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-190) | CHW: (+160)
• Spread: SD: -1.5 (-125) | CHW: +1.5 (+104)
• Total: 8 -- Over: (-114) | Under: (-106)

Padres vs White Sox Probable Starting Pitchers

Probable Pitchers: Dylan Cease (Padres) - 8-11, 4.59 ERA vs Davis Martin (White Sox) - 6-10, 4.01 ERA

The Padres will give the nod to Dylan Cease (8-11, 4.59 ERA), who is eyeing win No. 9 on the season, and the White Sox will turn to Davis Martin (6-10, 4.01 ERA). Cease's team is 14-16-0 against the spread in his starts this season. Cease's team is 14-7 this season when he starts and they are the moneyline favorite. The White Sox have gone 11-11-0 ATS in Martin's 22 starts with a set spread. The White Sox are 8-14 in Martin's 22 starts this season that they were the underdog on the moneyline.

Padres vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (63.5%)

Padres vs White Sox Moneyline

• Looking at the moneyline for White Sox-Padres, Chicago is the underdog at +160, and San Diego is -190 playing on the road.

Padres vs White Sox Spread

• The Padres are at the White Sox and are favored by 1.5 runs on the spread. The Padres are -125 to cover the runline, with the White Sox being +104.

Padres vs White Sox Over/Under

• The Padres-White Sox game on Sept. 19 has been given an over/under of 8 runs. The over is set at -114 and the under at -106.

Bet on San Diego Padres vs. Chicago White Sox on FanDuel today!

Padres vs White Sox Betting Trends

• The Padres have won in 49, or 59.8%, of the 82 contests they have been named as odds-on favorites in this year.
• This season San Diego has come away with a win 14 times in 21 chances when named as a favorite of at least -190 on the moneyline.
• Contests with the Padres have gone over the total set by bookmakers in 66 of 151 chances this season.
• The Padres are 81-70-0 against the spread in their 151 games with a line set by sportsbooks this season.
• The White Sox have gone 53-91 in games they were listed as the moneyline underdog (winning 36.8% of those games).
• Chicago has a 13-37 record (winning only 26% of its games) when playing as a moneyline underdog of +160 or longer.
• In the 148 games oddsmakers have set an over/under for the White Sox, they have combined with opponents to go over the total 68 times (68-72-8).
• The White Sox have collected an 84-64-0 record ATS this season.

Padres Player Leaders

• Fernando Tatis Jr. is hitting .266 with 27 doubles, two triples, 22 home runs and 88 walks. He has an on-base percentage of .369 while slugging .436.
• Among all qualifying hitters in the majors, his batting average ranks 46th, his on-base percentage ranks 13th, and he is 69th in slugging.
• Tatis has picked up at least one hit in two straight games. In his last five games he is batting .500 with a home run, four walks and two RBIs.
• Manny Machado leads San Diego with 164 hits. He is batting .279 this season and has 59 extra-base hits. He's also slugging .468 with an on-base percentage of .339.
• His batting average is 27th among qualified players, his on-base percentage 51st, and his slugging percentage 42nd.
• Machado heads into this game looking to extend his five-game hit streak. In his last five games he is batting .474 with three home runs, two walks and eight RBIs.
• Luis Arraez has hit seven homers with a team-high .386 SLG this season.
• Arraez enters this game with seven games in a row with at least one hit. During his last 10 outings he is hitting .297 with three walks and two RBIs.
• Ramon Laureano has been key for San Diego with 121 hits, an OBP of .347 plus a slugging percentage of .524.

White Sox Player Leaders

• Miguel Vargas a has .308 on-base percentage to pace the White Sox. He's batting .227 while slugging .391.
• Including all the qualifying hitters in the majors, he is 136th in batting average, 111th in on-base percentage and 111th in slugging percentage.
• Andrew Benintendi has 16 doubles, two triples, 20 home runs and 39 walks while hitting .240. He's slugging .431 with an on-base percentage of .306.
• Lenyn Sosa has racked up a slugging percentage of .424 and has 128 hits, both team-best numbers for the White Sox.
• Chase Meidroth is hitting .269 with 15 doubles, five home runs and 44 walks.

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