Padres vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 4:11 a.m.

The MLB's Friday slate includes the San Diego Padres taking on the Arizona Diamondbacks.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs Diamondbacks Game Info

• San Diego Padres (89-70) vs. Arizona Diamondbacks (85-74)
• Date: Friday, September 25, 2026
• Time: 9:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and Dbacks.TV

Padres vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-132) | ARI: (+112)
• Spread: SD: -1.5 (+172) | ARI: +1.5 (-210)
• Total: 7.5 -- Over: (-108) | Under: (-112)

Padres vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Casey Mize (Padres) - 6-9, 3.96 ERA vs Brandon Pfaadt (Diamondbacks) - 7-3, 3.72 ERA

This contest's pitching matchup is set, as the Padres will send Casey Mize (6-9) to the mound, while Brandon Pfaadt (7-3) will get the nod for the Diamondbacks. Mize and his team are 11-14-0 ATS this season when he starts. When Mize starts a game and his team is the favorite on the moneyline, they have a record of 9-6. The Diamondbacks have a 15-3-0 ATS record in Pfaadt's 18 starts that had a set spread. The Diamondbacks have been the underdog on the moneyline in 11 of Pfaadt's starts this season, and they went 8-3 in those games.

Padres vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (64.1%)

Padres vs Diamondbacks Moneyline

• The moneyline numbers for Padres vs. Diamondbacks reveal San Diego as the favorite (-132) and Arizona as the underdog (+112) on the road.

Padres vs Diamondbacks Spread

• The Padres are hosting the Diamondbacks and are favored by 1.5 runs (+172 to cover) on the runline. Arizona is -210 to cover.

Padres vs Diamondbacks Over/Under

• Padres versus Diamondbacks, on Sept. 25, has an over/under of 7.5, with the over being -108 and the under -112.

Bet on San Diego Padres vs. Arizona Diamondbacks on FanDuel today!

Padres vs Diamondbacks Betting Trends

• The Padres have been chosen as favorites in 78 games this year and have walked away with the win 48 times (61.5%) in those games.
• San Diego has a record of 34-15 in contests when sportsbooks favor them by -132 or more on the moneyline.
• The Padres and their opponents have gone over the total this season in 74 of their 159 opportunities.
• In 159 games with a line this season, the Padres have a mark of 92-67-0 against the spread.
• The Diamondbacks have won 39 of the 82 games they were listed as the moneyline underdog this season (47.6%).
• Arizona has a 24-26 record (winning 48% of its games) when it has played as a moneyline underdog of +112 or longer.
• The Diamondbacks have combined with opponents to hit the over on the total 68 times this season for a 68-85-4 record against the over/under.
• The Diamondbacks have put together an 83-74-0 record ATS this season (covering 52.9% of the time).

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego in OBP (.358), slugging percentage (.470) and total hits (179) this season. He has a .289 batting average.
• Among all qualifying hitters in the majors, his batting average ranks 12th, his on-base percentage ranks 33rd, and he is 31st in slugging.
• Tatis has picked up at least one hit in seven straight games. During his last 10 outings he is batting .286 with two doubles, four home runs, three walks and seven RBIs.
• Jackson Merrill is batting .252 with 26 doubles, five triples, 26 home runs and 40 walks. He's slugging .440 with an on-base percentage of .300.
• Among qualifiers, he is 75th in batting average, 115th in on-base percentage and 54th in slugging percentage.
• Manny Machado has 125 hits this season and has a slash line of .216/.304/.405.
• Xander Bogaerts has 12 home runs, 56 RBI and a batting average of .227 this season.

Diamondbacks Player Leaders

• Corbin Carroll is hitting .240 with 32 doubles, 17 triples, 22 home runs and 73 walks. He's slugging .472 with an on-base percentage of .331.
• Including all the qualifying hitters in the big leagues, his batting average is 96th, his on-base percentage ranks 67th, and he is 30th in slugging.
• Carroll hopes to build on a four-game hitting streak in this matchup. During his last five outings he is batting .250 with a double, a triple, three walks and six RBIs.
• Gabriel Moreno paces his team with 144 hits and a .384 on-base percentage, with a team-high .486 slugging percentage. He has a batting average of .308.
• Including all qualified players, he ranks third in batting average, seventh in on-base percentage and 20th in slugging percentage.
• Geraldo Perdomo has a .373 slugging percentage, which leads the Diamondbacks.
• Ketel Marte is batting .250 with 30 doubles, three triples, 22 home runs and 50 walks.

Padres vs Diamondbacks Head to Head

• 8/6/2026: 5-1 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -104, Underdog Moneyline: -104)
• 8/5/2026: 10-4 ARI (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +122)
• 8/4/2026: 9-4 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -114, Underdog Moneyline: +104)
• 8/3/2026: 5-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: +100)
• 7/9/2026: 3-1 ARI (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/8/2026: 10-4 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/7/2026: 4-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/6/2026: 8-0 ARI (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/26/2026: 12-7 ARI (Favorite: Padres, Spread: -1.5, Total: 15, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/25/2026: 6-4 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 16, Favorite Moneyline: -116, Underdog Moneyline: -102)

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