Padres vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 9:11 p.m.

The Friday schedule in MLB includes a matchup between the San Diego Padres and the Arizona Diamondbacks.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Padres vs Diamondbacks Game Info

• San Diego Padres (89-70) vs. Arizona Diamondbacks (85-74)
• Date: Friday, September 25, 2026
• Time: 9:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and Dbacks.TV

Padres vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-126) | ARI: (+108)
• Spread: SD: -1.5 (+168) | ARI: +1.5 (-205)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Padres vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Casey Mize (Padres) - 6-9, 3.96 ERA vs Brandon Pfaadt (Diamondbacks) - 7-3, 3.72 ERA

The probable pitchers are Casey Mize (6-9) for the Padres and Brandon Pfaadt (7-3) for the Diamondbacks. When Mize starts, his team is 11-14-0 against the spread this season. Mize's team is 9-6 this season when he starts and they are the moneyline favorite. The Diamondbacks have a 15-3-0 ATS record in Pfaadt's 18 starts that had a set spread. The Diamondbacks have been the underdog on the moneyline in 11 of Pfaadt's starts this season, and they went 8-3 in those matchups.

Padres vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (60.7%)

Padres vs Diamondbacks Moneyline

• San Diego is a -126 favorite on the moneyline, while Arizona is a +108 underdog on the road.

Padres vs Diamondbacks Spread

• The Diamondbacks are at the Padres, and are +1.5 on the runline. The Diamondbacks are +168 to cover the spread, and the Padres are -205.

Padres vs Diamondbacks Over/Under

• The Padres-Diamondbacks contest on Sept. 25 has been given an over/under of 7.5 runs. The over is set at -115 and the under at -105.

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Padres vs Diamondbacks Betting Trends

• The Padres have been victorious in 48, or 61.5%, of the 78 contests they have been chosen as favorites in this season.
• This season San Diego has been victorious 34 times in 54 chances when named as a favorite of at least -126 on the moneyline.
• The Padres' games have gone over the total in 74 of their 159 opportunities.
• In 159 games with a line this season, the Padres have a mark of 92-67-0 against the spread.
• The Diamondbacks have won 47.6% of the games this season they were the moneyline underdog (39-43).
• When playing as a moneyline underdog with odds of +108 or longer, Arizona has a 27-32 record (winning 45.8% of its games).
• The Diamondbacks have combined with opponents to go over the total 68 times this season for a 68-85-4 record against the over/under.
• The Diamondbacks have collected an 83-74-0 record ATS this season.

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego in OBP (.358), slugging percentage (.470) and total hits (179) this season. He has a .289 batting average.
• Among the qualifying hitters in baseball, his batting average ranks 12th, his on-base percentage ranks 33rd, and he is 31st in slugging.
• Tatis hopes to build on a seven-game hitting streak in this matchup. In his last 10 games he is batting .286 with two doubles, four home runs, three walks and seven RBIs.
• Jackson Merrill has 26 doubles, five triples, 26 home runs and 40 walks. He's batting .252 and slugging .440 with an on-base percentage of .300.
• Among qualified hitters, he is 75th in batting average, 115th in on-base percentage and 54th in slugging percentage.
• Manny Machado is batting .216 with a .405 slugging percentage and 87 RBI this year.
• Xander Bogaerts has been key for San Diego with 117 hits, an OBP of .327 plus a slugging percentage of .335.

Diamondbacks Player Leaders

• Corbin Carroll has 32 doubles, 17 triples, 22 home runs and 73 walks while hitting .240. He's slugging .472 with an on-base percentage of .331.
• He is 97th in batting average, 67th in on-base percentage and 30th in slugging percentage among all qualified hitters in the majors.
• Carroll takes a four-game hitting streak into this game. During his last five outings he is hitting .250 with a double, a triple, three walks and six RBIs.
• Gabriel Moreno's 144 hits, .384 OBP and .486 slugging percentage all pace his team. He has a batting average of .308.
• Including all qualifying hitters, he is third in batting average, seventh in on-base percentage and 20th in slugging percentage.
• Geraldo Perdomo has accumulated a team-high .373 slugging percentage.
• Ketel Marte is batting .250 with 30 doubles, three triples, 22 home runs and 50 walks.

Padres vs Diamondbacks Head to Head

• 8/6/2026: 5-1 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -104, Underdog Moneyline: -104)
• 8/5/2026: 10-4 ARI (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +122)
• 8/4/2026: 9-4 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -114, Underdog Moneyline: +104)
• 8/3/2026: 5-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: +100)
• 7/9/2026: 3-1 ARI (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/8/2026: 10-4 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/7/2026: 4-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/6/2026: 8-0 ARI (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/26/2026: 12-7 ARI (Favorite: Padres, Spread: -1.5, Total: 15, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/25/2026: 6-4 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 16, Favorite Moneyline: -116, Underdog Moneyline: -102)

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