Guardians vs Royals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 7:11 p.m.

The Cleveland Guardians versus the Kansas City Royals is on the MLB schedule for Friday.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Royals Game Info

• Cleveland Guardians (83-76) vs. Kansas City Royals (68-91)
• Date: Friday, September 25, 2026
• Time: 7:40 p.m. ET
• Venue: Kauffman Stadium -- Kansas City, Missouri
• Coverage: Royals.TV and CleGuardians.TV

Guardians vs Royals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-142) | KC: (+120)
• Spread: CLE: -1.5 (+120) | KC: +1.5 (-144)
• Total: 7.5 -- Over: (+106) | Under: (-130)

Guardians vs Royals Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 14-8, 3.63 ERA vs Noah Cameron (Royals) - 9-8, 3.92 ERA

This contest's pitching matchup is set, as the Guardians will send Gavin Williams (14-8) to the mound, while Noah Cameron (9-8) will get the nod for the Royals. Williams and his team have a record of 14-15-0 against the spread when he starts. Williams' team is 14-10 this season when he starts and they are the moneyline favorite. When Cameron starts, the Royals have gone 12-14-0 against the spread. The Royals have a 2-12 record in Cameron's 14 starts this season when they were the underdog on the moneyline.

Guardians vs Royals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (54.4%)

Guardians vs Royals Moneyline

• Looking at the moneyline for Royals-Guardians, Kansas City is the underdog at +120, and Cleveland is -142 playing on the road.

Guardians vs Royals Spread

• The Guardians are at the Royals and are favored by 1.5 runs on the spread. The Guardians are +120 to cover the runline, with the Royals being -144.

Guardians vs Royals Over/Under

• The Guardians-Royals game on Sept. 25 has been given an over/under of 7.5 runs. The over is set at +106 and the under at -130.

Bet on Cleveland Guardians vs. Kansas City Royals on FanDuel today!

Guardians vs Royals Betting Trends

• The Guardians have been chosen as favorites in 89 games this year and have walked away with the win 47 times (52.8%) in those games.
• This season Cleveland has been victorious 22 times in 34 chances when named as a favorite of at least -142 on the moneyline.
• The Guardians' games have gone over the total in 73 of their 150 opportunities.
• The Guardians have posted a record of 72-78-0 against the spread this season.
• The Royals have won 39 of the 101 games they were listed as the moneyline underdog this season (38.6%).
• Kansas City has a 14-27 record (winning only 34.1% of its games) when it has played as a moneyline underdog of +120 or longer.
• The Royals have played in 152 games with a set over/under, and have combined with their opponents to go over the total 70 times (70-79-3).
• The Royals have a 76-76-0 record ATS this season (covering 50% of the time).

Guardians Player Leaders

• Chase DeLauter leads Cleveland in total hits (140) this season while batting .287 with 47 extra-base hits. He has an on-base percentage of .361 and a slugging percentage of .452.
• Among the qualified hitters in the majors, his batting average ranks 13th, his on-base percentage ranks 27th, and he is 42nd in slugging.
• Steven Kwan has a slash line of .280/.378/.344 this season and a team-best OPS of .722.
• Among all qualifying batters, he is 22nd in batting average, 11th in on-base percentage and 129th in slugging percentage.
• Jose Ramirez has 110 hits this season and has a slash line of .237/.323/.373.
• Brayan Rocchio has been key for Cleveland with 131 hits, an OBP of .310 plus a slugging percentage of .376.

Royals Player Leaders

• Bobby Witt Jr. has a .360 on-base percentage and a .443 slugging percentage, both team-high numbers for the Royals. He's batting .282.
• He ranks 18th in batting average, 28th in on-base percentage and 52nd in slugging percentage among all qualified hitters in the majors.
• Witt enters this game on a six-game hitting streak. In his last 10 games he is hitting .308 with two doubles and four walks.
• Carter Jensen is hitting .235 with 33 doubles, two triples, 25 home runs and 64 walks. He's slugging .451 with an on-base percentage of .320.
• Including all qualifying hitters, his batting average puts him 104th, his on-base percentage ranks 87th, and he is 44th in slugging.
• Jac Caglianone paces the Royals with 141 hits.
• Vinnie Pasquantino is batting .246 with 20 doubles, two triples, 15 home runs and 50 walks.

Guardians vs Royals Head to Head

• 8/30/2026: 11-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +164)
• 8/29/2026: 8-3 KC (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +146)
• 8/28/2026: 3-0 KC (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +120)
• 5/7/2026: 8-5 CLE (Favorite: Royals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 5/6/2026: 3-1 CLE (Favorite: Royals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 5/5/2026: 5-3 KC (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/4/2026: 6-2 KC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/8/2026: 10-2 CLE (Favorite: Royals, Spread: -1.5, Total: 7, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/7/2026: 2-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/6/2026: 4-2 KC (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -118, Underdog Moneyline: +100)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!