Guardians vs Royals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 2:11 a.m.

The MLB schedule on Friday includes the Cleveland Guardians facing the Kansas City Royals.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Guardians vs Royals Game Info

• Cleveland Guardians (83-76) vs. Kansas City Royals (68-91)
• Date: Friday, September 25, 2026
• Time: 7:40 p.m. ET
• Venue: Kauffman Stadium -- Kansas City, Missouri
• Coverage: Royals.TV and CleGuardians.TV

Guardians vs Royals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-142) | KC: (+120)
• Spread: CLE: -1.5 (+122) | KC: +1.5 (-146)
• Total: 7.5 -- Over: (-122) | Under: (+100)

Guardians vs Royals Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 14-8, 3.63 ERA vs Noah Cameron (Royals) - 9-8, 3.92 ERA

The probable pitchers are Gavin Williams (14-8) for the Guardians and Noah Cameron (9-8) for the Royals. Williams' team is 14-15-0 against the spread in his starts this season. Williams' team has been victorious in 58.3% of the games he's started as the moneyline favorite with a record of 14-10. The Royals have a 12-14-0 ATS record in Cameron's 26 starts that had a set spread. The Royals are 2-12 in Cameron's 14 starts this season that they were the underdog on the moneyline.

Guardians vs Royals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Royals win (56.2%)

Guardians vs Royals Moneyline

• Looking at the moneyline for Royals-Guardians, Kansas City is the underdog at +120, and Cleveland is -142 playing on the road.

Guardians vs Royals Spread

• The Royals are +1.5 on the spread (-146 to cover), and Cleveland is +122 to cover the runline.

Guardians vs Royals Over/Under

• The Guardians-Royals contest on Sept. 25 has been given an over/under of 7.5 runs. The over is set at -122 and the under at +100.

Bet on Cleveland Guardians vs. Kansas City Royals on FanDuel today!

Guardians vs Royals Betting Trends

• The Guardians have won in 47, or 52.8%, of the 89 contests they have been named as odds-on favorites in this year.
• This year Cleveland has won 22 of 34 games when listed as at least -142 on the moneyline.
• The Guardians and their opponents have gone over in 73 of their 150 games with a total set by sportsbooks this season.
• In 150 games with a line this season, the Guardians have a mark of 72-78-0 against the spread.
• The Royals have been the underdog on the moneyline 101 total times this season. They've finished 39-62 in those games.
• Kansas City has gone 14-27 in games it has played as a moneyline underdog with odds of +120 or longer (34.1%).
• The Royals have played in 152 games with an over/under set, and have combined with opponents to go over the total 70 times (70-79-3).
• The Royals have covered 50% of their games this season, going 76-76-0 against the spread.

Guardians Player Leaders

• Chase DeLauter leads Cleveland with 140 hits, batting .287 this season with 47 extra-base hits. He has an on-base percentage of .361 and a slugging percentage of .452.
• Among all qualified batters in baseball, he is 13th in batting average, 27th in on-base percentage, and 42nd in slugging.
• Steven Kwan leads the Guardians with an OPS of .722. He has a slash line of .280/.378/.344 this season.
• Among qualified batters, his batting average ranks him 22nd, his on-base percentage 11th, and his slugging percentage 129th.
• Jose Ramirez is batting .237 with a .373 slugging percentage and 51 RBI this year.
• Brayan Rocchio has been key for Cleveland with 131 hits, an OBP of .310 plus a slugging percentage of .376.

Royals Player Leaders

• Bobby Witt Jr. has racked up an on-base percentage of .360 and a slugging percentage of .443. Both lead the Royals. He's batting .282.
• Including all the qualifying hitters in the majors, he ranks 18th in batting average, 28th in on-base percentage and 52nd in slugging percentage.
• Witt enters this matchup on a six-game hitting streak. During his last 10 outings he is hitting .308 with two doubles and four walks.
• Carter Jensen is batting .235 with 33 doubles, two triples, 25 home runs and 64 walks. He's slugging .451 with an on-base percentage of .320.
• He is 104th in batting average, 87th in on-base percentage and 45th in slugging percentage in MLB.
• Jac Caglianone has racked up 141 hits, a team-high for the Royals.
• Vinnie Pasquantino has 20 doubles, two triples, 15 home runs and 50 walks while hitting .246.

Guardians vs Royals Head to Head

• 8/30/2026: 11-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +164)
• 8/29/2026: 8-3 KC (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +146)
• 8/28/2026: 3-0 KC (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +120)
• 5/7/2026: 8-5 CLE (Favorite: Royals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 5/6/2026: 3-1 CLE (Favorite: Royals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 5/5/2026: 5-3 KC (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/4/2026: 6-2 KC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/8/2026: 10-2 CLE (Favorite: Royals, Spread: -1.5, Total: 7, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/7/2026: 2-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/6/2026: 4-2 KC (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -118, Underdog Moneyline: +100)

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