Mariners vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 4:12 a.m.

The Seattle Mariners versus the Los Angeles Angels is on the MLB schedule for Friday.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Mariners vs Angels Game Info

• Seattle Mariners (74-85) vs. Los Angeles Angels (61-98)
• Date: Friday, September 25, 2026
• Time: 10:10 p.m. ET
• Venue: T-Mobile Park -- Seattle, Washington
• Coverage: Mariners.TV and ABTV

Mariners vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-132) | LAA: (+112)
• Spread: SEA: -1.5 (+180) | LAA: +1.5 (-220)
• Total: 6.5 -- Over: (-138) | Under: (+112)

Mariners vs Angels Probable Starting Pitchers

Probable Pitchers: Bryce Miller (Mariners) - 4-9, 3.99 ERA vs Reid Detmers (Angels) - 6-8, 3.47 ERA

The probable starters are Bryce Miller (4-9) for the Mariners and Reid Detmers (6-8) for the Angels. Miller and his team have a record of 2-17-0 against the spread when he starts. Miller's team is 3-12 this season when he starts and they are the moneyline favorite. The Angels have a 15-16-0 ATS record in Detmers' 31 starts that had a set spread. The Angels have a 7-16 record in Detmers' 23 starts this season when they were the underdog on the moneyline.

Mariners vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (50.7%)

Mariners vs Angels Moneyline

• Seattle is the favorite, -132 on the moneyline, while Los Angeles is a +112 underdog on the road.

Mariners vs Angels Spread

• The Mariners are hosting the Angels and are favored by 1.5 runs on the spread. The Mariners are +180 to cover the runline, with the Angels being -220.

Mariners vs Angels Over/Under

• The over/under for the Mariners versus Angels game on Sept. 25 has been set at 6.5, with -138 odds on the over and +112 odds on the under.

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Mariners vs Angels Betting Trends

• The Mariners have been favorites in 122 games this season and have come away with the win 60 times (49.2%) in those contests.
• This season Seattle has been victorious 45 times in 81 chances when named as a favorite of at least -132 on the moneyline.
• The Mariners and their opponents have hit the over in 83 of their 157 games with a total set by oddsmakers this season.
• The Mariners are 56-101-0 against the spread in their 157 games with a line set by sportsbooks this season.
• The Angels have been the moneyline underdog 127 total times this season. They've finished 45-82 in those games.
• Los Angeles has a 35-59 record (winning just 37.2% of its games) when playing as a moneyline underdog of +112 or longer.
• The Angels have had an over/under set by bookmakers 158 times, and have combined with opponents to go over the total in 67 of those games (67-88-3).
• The Angels have collected an 83-75-0 record ATS this season (covering 52.5% of the time).

Mariners Player Leaders

• Randy Arozarena leads Seattle with 156 hits and an OBP of .380, plus a team-best slugging percentage of .479. He's batting .279.
• He ranks 25th in batting average, 10th in on-base percentage, and 25th in slugging among qualified hitters in MLB.
• Arozarena will look for his third straight game with a hit in this contest. In his last five games he is batting .200 with a double, a home run, five walks and an RBI.
• Josh Naylor is batting .265 with 22 doubles, 10 home runs and 44 walks, while slugging .354 with an on-base percentage of .321.
• Among all qualifying batters, he is 49th in batting average, 85th in on-base percentage and 126th in slugging percentage.
• Julio Rodriguez has collected 147 base hits, an OBP of .311 and a slugging percentage of .407 this season.
• Rodriguez has recorded at least one base hit in five games in a row. In his last five games he is batting .526 with two doubles, a home run, a walk and four RBIs.
• Dominic Canzone has been key for Seattle with 121 hits, an OBP of .330 plus a slugging percentage of .477.

Angels Player Leaders

• Zach Neto has put up a team-best slugging percentage (.431) and paces the Angels in hits (145). He's batting .238 and with an on-base percentage of .327.
• Including all the qualifying hitters in MLB, he is 101st in batting average, 77th in on-base percentage and 63rd in slugging percentage.
• Neto hopes to build on a three-game hitting streak in this matchup. In his last five games he is batting .176 with five walks and an RBI.
• Mike Trout paces his team with a .385 on-base percentage. He has a batting average of .246 while slugging .428.
• Including all qualifying players, he is 87th in batting average, fifth in on-base percentage and 65th in slugging percentage.
• Vaughn Grissom has 22 doubles, 13 home runs and 30 walks while batting .241.
• Wade Meckler has 14 doubles, three home runs and 32 walks while hitting .298.

Mariners vs Angels Head to Head

• 9/24/2026: 6-4 LAA (Favorite: Mariners, Spread: -1.5, Total: 6.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/16/2026: 7-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/15/2026: 2-1 LAA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 9/14/2026: 6-4 LAA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/2/2026: 1-0 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 6/30/2026: 8-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 6/29/2026: 6-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 4/5/2026: 8-7 LAA (Favorite: Mariners, Spread: -1.5, Total: 9, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/4/2026: 1-0 LAA (Favorite: Mariners, Spread: -1.5, Total: 9.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/3/2026: 3-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)

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