Mariners vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 10:11 p.m.

The Friday schedule in MLB includes a matchup between the Seattle Mariners and the Los Angeles Angels.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this matchup.

Mariners vs Angels Game Info

• Seattle Mariners (74-85) vs. Los Angeles Angels (61-98)
• Date: Friday, September 25, 2026
• Time: 10:10 p.m. ET
• Venue: T-Mobile Park -- Seattle, Washington
• Coverage: Mariners.TV and ABTV

Mariners vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-118) | LAA: (+100)
• Spread: SEA: +1.5 (-210) | LAA: -1.5 (+172)
• Total: 6.5 -- Over: (-115) | Under: (-105)

Mariners vs Angels Probable Starting Pitchers

Probable Pitchers: Bryce Miller (Mariners) - 4-9, 3.99 ERA vs Reid Detmers (Angels) - 6-8, 3.47 ERA

The probable starters are Bryce Miller (4-9) for the Mariners and Reid Detmers (6-8) for the Angels. Miller's team is 2-17-0 against the spread in his starts this season. Miller's team has been victorious in 20% of the games he's started as the moneyline favorite with a record of 3-12. The Angels have gone 15-16-0 against the spread when Detmers starts. The Angels have been the moneyline underdog in 23 of Detmers' starts this season, and they went 7-16 in those matchups.

Mariners vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (62.7%)

Mariners vs Angels Moneyline

• The Mariners vs Angels moneyline has Seattle as a -118 favorite, while Los Angeles is a +100 underdog on the road.

Mariners vs Angels Spread

• The Angels are 1.5-run favorites against the spread for this matchup with the Mariners. The Angels are +172 to cover, while the Mariners are -210 to cover as a 1.5-run underdog on the runline.

Mariners vs Angels Over/Under

• The Mariners-Angels contest on Sept. 25 has been given an over/under of 6.5 runs. The over is set at -115 and the under at -105.

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Mariners vs Angels Betting Trends

• The Mariners have won in 60, or 49.2%, of the 122 contests they have been named as odds-on favorites in this year.
• This season Seattle has been victorious 55 times in 106 chances when named as a favorite of at least -118 on the moneyline.
• The Mariners and their opponents have gone over in 83 of their 157 games with a total set by sportsbooks this season.
• The Mariners have posted a record of 56-101-0 against the spread this season.
• The Angels are 45-82 in games they were listed as the moneyline underdog (winning 35.4% of those games).
• Los Angeles is 40-70 (winning just 36.4% of its games) when it has played as a moneyline underdog of +100 or longer.
• The Angels have played in 158 games with a set over/under, and have combined with opponents to go over the total 67 times (67-88-3).
• The Angels are 83-75-0 against the spread this season.

Mariners Player Leaders

• Randy Arozarena leads Seattle in OBP (.380), slugging percentage (.479) and total hits (156) this season. He has a .279 batting average.
• Among all qualified hitters in MLB, his batting average ranks 24th, his on-base percentage ranks 10th, and he is 25th in slugging.
• Arozarena hopes to build on a two-game hitting streak in this matchup. During his last five outings he is hitting .200 with a double, a home run, five walks and an RBI.
• Josh Naylor has 22 doubles, 10 home runs and 44 walks. He's batting .265 and slugging .354 with an on-base percentage of .321.
• He is 50th in batting average, 85th in on-base percentage and 126th in slugging in MLB.
• Julio Rodriguez has collected 147 base hits, an OBP of .311 and a slugging percentage of .407 this season.
• Rodriguez has recorded at least one base hit in five games in a row. During his last five outings he is batting .526 with two doubles, a home run, a walk and four RBIs.
• Dominic Canzone has 22 home runs, 75 RBI and a batting average of .260 this season.

Angels Player Leaders

• Zach Neto has a slugging percentage of .431 and has 145 hits, both team-best numbers for the Angels. He's batting .238 and with an on-base percentage of .327.
• Including all the qualified players in MLB, his batting average ranks 101st, his on-base percentage ranks 77th, and he is 63rd in slugging.
• Neto enters this matchup on a three-game hitting streak. In his last five games he is batting .176 with five walks and an RBI.
• Mike Trout has a .385 on-base percentage to lead his team. He has a batting average of .246 while slugging .428.
• He ranks 87th in batting average, fifth in on-base percentage and 65th in slugging percentage in the big leagues.
• Vaughn Grissom has 22 doubles, 13 home runs and 30 walks while hitting .241.
• Wade Meckler is batting .298 with 14 doubles, three home runs and 32 walks.

Mariners vs Angels Head to Head

• 9/24/2026: 6-4 LAA (Favorite: Mariners, Spread: -1.5, Total: 6.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/16/2026: 7-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/15/2026: 2-1 LAA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 9/14/2026: 6-4 LAA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/2/2026: 1-0 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 6/30/2026: 8-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 6/29/2026: 6-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 4/5/2026: 8-7 LAA (Favorite: Mariners, Spread: -1.5, Total: 9, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/4/2026: 1-0 LAA (Favorite: Mariners, Spread: -1.5, Total: 9.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/3/2026: 3-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)

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