White Sox vs Rockies Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 7:11 p.m.

The Chicago White Sox are among the MLB teams in action on Friday, versus the Colorado Rockies.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

White Sox vs Rockies Game Info

• Chicago White Sox (82-77) vs. Colorado Rockies (57-102)
• Date: Friday, September 25, 2026
• Time: 7:40 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and Rockies.TV

White Sox vs Rockies Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHW: (-250) | COL: (+205)
• Spread: CHW: -1.5 (-114) | COL: +1.5 (-105)
• Total: 8.5 -- Over: (-105) | Under: (-115)

White Sox vs Rockies Probable Starting Pitchers

Probable Pitchers: Sean Burke (White Sox) - 10-7, 3.40 ERA vs Tomoyuki Sugano (Rockies) - 12-11, 5.36 ERA

This contest's pitching matchup is set, as the White Sox will send Sean Burke (10-7) to the mound, while Tomoyuki Sugano (12-11) will get the nod for the Rockies. When Burke starts, his team is 14-12-0 against the spread this season. Burke's team has a record of 8-3 this season when he starts and they are the favorite on the moneyline. The Rockies have a 17-10-0 ATS record in Sugano's 27 starts with a set spread. The Rockies are 14-13 in Sugano's 27 starts this season that they were the underdog on the moneyline.

White Sox vs Rockies Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: White Sox win (68.1%)

White Sox vs Rockies Moneyline

• Chicago is a -250 favorite on the moneyline, while Colorado is a +205 underdog on the road.

White Sox vs Rockies Spread

• The White Sox are 1.5-run home favorites on the runline against the Rockies. The White Sox are -114 to cover, and the Rockies are -105.

White Sox vs Rockies Over/Under

• The over/under for the White Sox versus Rockies game on Sept. 25 has been set at 8.5, with -105 odds on the over and -115 odds on the under.

Bet on Chicago White Sox vs. Colorado Rockies on FanDuel today!

White Sox vs Rockies Betting Trends

• The White Sox have been favorites in 43 games this season and have come away with the win 24 times (55.8%) in those contests.
• Oddsmakers have given Chicago the best odds of winning it has seen this season, with a -250 moneyline listed for this contest.
• The White Sox and their opponents have gone over in 88 of their 156 games with a total set by sportsbooks this season.
• In 156 games with a line this season, the White Sox have a mark of 88-68-0 against the spread.
• The Rockies have won 35.5% of the games this season they were the moneyline underdog (54-98).
• When playing as a moneyline underdog with odds of +205 or longer, Colorado has a 5-14 record (winning just 26.3% of its games).
• The Rockies have played in 156 games with an over/under set, and have combined with opponents to go over the total 76 times (76-77-3).
• The Rockies have an 81-75-0 record against the spread this season (covering 51.9% of the time).

White Sox Player Leaders

• Miguel Vargas has 147 hits, which is tops among Chicago hitters this season, while batting .252 with 65 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .479.
• Among qualified batters in baseball, he ranks 75th in batting average, 25th in on-base percentage, and 25th in slugging.
• Vargas hopes to build on a six-game hitting streak in this matchup. In his last 10 outings he is hitting .333 with a double, three home runs, 10 walks and 13 RBIs.
• Chase Meidroth has hit 16 homers this season while driving in 63 runs. He's batting .275 this season and slugging .413 with an on-base percentage of .350.
• He is 33rd in batting average, 42nd in on-base percentage and 79th in slugging in MLB.
• Meidroth enters this game looking to extend his four-game hit streak. During his last five outings he is batting .444 with a double, two home runs, a walk and seven RBIs.
• Sam Antonacci leads Chicago in OBP (.365) this season, fueled by 127 hits.
• Antonacci enters this matchup with three games in a row with at least one hit. During his last five outings he is batting .278 with a double, a walk and three RBIs.
• Tristan Peters has been key for Chicago with 115 hits, an OBP of .341 plus a slugging percentage of .444.

Rockies Player Leaders

• Jake McCarthy has 30 doubles, 13 triples, 15 home runs and 29 walks while hitting .295. He's slugging .483 with an on-base percentage of .337.
• Including all the qualified players in the big leagues, he is eighth in batting average, 58th in on-base percentage and 23rd in slugging percentage.
• TJ Rumfield paces his team with a .388 on-base percentage, and has a club-leading .446 slugging percentage. He has a batting average of .297.
• Including all qualifying players, his batting average places him seventh, his on-base percentage is third, and he is 48th in slugging.
• Hunter Goodman has collected 124 hits, a team-high for the Rockies.
• Kyle Karros is hitting .258 with 21 doubles, three triples, 13 home runs and 53 walks.

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