White Sox vs Rockies Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 2:11 a.m.

The MLB slate on Friday includes the Chicago White Sox facing the Colorado Rockies.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

White Sox vs Rockies Game Info

• Chicago White Sox (82-77) vs. Colorado Rockies (57-102)
• Date: Friday, September 25, 2026
• Time: 7:40 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and Rockies.TV

White Sox vs Rockies Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHW: (-235) | COL: (+194)
• Spread: CHW: -1.5 (+100) | COL: +1.5 (-120)
• Total: 8.5 -- Over: (+110) | Under: (-134)

White Sox vs Rockies Probable Starting Pitchers

Probable Pitchers: Sean Burke (White Sox) - 10-7, 3.40 ERA vs Tomoyuki Sugano (Rockies) - 12-11, 5.36 ERA

This contest's pitching matchup is set, as the White Sox will send Sean Burke (10-7) to the mound, while Tomoyuki Sugano (12-11) will take the ball for the Rockies. Burke's team is 14-12-0 against the spread this season in his starts. When Burke starts a game and his team is the favorite on the moneyline, they have a record of 8-3. The Rockies are 17-10-0 against the spread when Sugano starts. The Rockies are 14-13 in Sugano's 27 starts this season that they were the underdog on the moneyline.

White Sox vs Rockies Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: White Sox win (62.1%)

White Sox vs Rockies Moneyline

• The White Sox vs Rockies moneyline has Chicago as a -235 favorite, while Colorado is a +194 underdog on the road.

White Sox vs Rockies Spread

• The Rockies are +1.5 on the spread (-120 to cover), and Chicago is +100 to cover the runline.

White Sox vs Rockies Over/Under

• White Sox versus Rockies, on Sept. 25, has an over/under of 8.5, with the over being +110 and the under -134.

Bet on Chicago White Sox vs. Colorado Rockies on FanDuel today!

White Sox vs Rockies Betting Trends

• The White Sox have won in 24, or 55.8%, of the 43 contests they have been named as odds-on favorites in this year.
• These are the best odds of a victory sportsbooks have given Chicago this season, with a -235 moneyline set for this game.
• The White Sox and their opponents have gone over in 88 of their 156 games with a total set by sportsbooks this season.
• The White Sox are 88-68-0 against the spread in their 156 games with a line set by sportsbooks this season.
• The Rockies have put together a 54-98 record in games they were listed as the moneyline underdog (winning 35.5% of those games).
• Colorado has a 6-18 record (winning only 25% of its games) when it has played as a moneyline underdog of +194 or longer.
• The Rockies have combined with opponents to go over the total 76 times this season for a 76-77-3 record against the over/under.
• The Rockies have collected an 81-75-0 record ATS this season.

White Sox Player Leaders

• Miguel Vargas leads Chicago with 147 hits, batting .252 this season with 65 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .479.
• He is 75th in batting average, 25th in on-base percentage, and 25th in slugging among all qualified hitters in baseball.
• Vargas has hit safely in six games in a row. In his last 10 games he is hitting .333 with a double, three home runs, 10 walks and 13 RBIs.
• Chase Meidroth has hit 16 homers this season while driving in 63 runs. He's batting .275 this season and slugging .413 with an on-base percentage of .350.
• His batting average is 33rd among qualified players, his on-base percentage 43rd, and his slugging percentage 79th.
• Meidroth has picked up a hit in four games in a row. During his last five outings he is hitting .444 with a double, two home runs, a walk and seven RBIs.
• Sam Antonacci leads Chicago in OBP (.365) this season, fueled by 127 hits.
• Antonacci brings a three-game hitting streak into this matchup. In his last five games he is batting .278 with a double, a walk and three RBIs.
• Tristan Peters is batting .269 with a .341 OBP and 56 RBI for Chicago this season.

Rockies Player Leaders

• Jake McCarthy is hitting .295 with 30 doubles, 13 triples, 15 home runs and 29 walks. He's slugging .483 with an on-base percentage of .337.
• Including all qualifying hitters, he is eighth in batting average, while his on-base percentage is 58th and he is 23rd in slugging.
• TJ Rumfield has a .388 OBP while slugging .446. Both pace his team. He has a batting average of .297.
• His batting average is seventh among all qualified players, his on-base percentage is third, and he is 48th in slugging.
• Hunter Goodman has collected 124 hits, a team-best for the Rockies.
• Kyle Karros has 21 doubles, three triples, 13 home runs and 53 walks while batting .258.

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