Brewers vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 2:11 a.m.

The Milwaukee Brewers versus the St. Louis Cardinals is on the MLB schedule for Friday.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Brewers vs Cardinals Game Info

• Milwaukee Brewers (100-59) vs. St. Louis Cardinals (77-82)
• Date: Friday, September 25, 2026
• Time: 7:40 p.m. ET
• Venue: American Family Field -- Milwaukee, Wisconsin
• Coverage: Brewers.TV and Cardinals.TV

Brewers vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-172) | STL: (+144)
• Spread: MIL: -1.5 (+130) | STL: +1.5 (-156)
• Total: 7.5 -- Over: (-142) | Under: (+116)

Brewers vs Cardinals Probable Starting Pitchers

Probable Pitchers: Robert Gasser (Brewers) - 5-5, 4.01 ERA vs Michael McGreevy (Cardinals) - 7-9, 3.84 ERA

This contest's pitching matchup is set, as the Brewers will send Robert Gasser (5-5) to the mound, while Michael McGreevy (7-9) will get the nod for the Cardinals. Gasser's team is 9-10-0 against the spread this season in his starts. Gasser's team has been victorious in 69.2% of the games he's started as the moneyline favorite with a record of 9-4. The Cardinals have a 17-13-0 record against the spread in McGreevy's starts. The Cardinals have an 11-10 record in McGreevy's 21 starts this season when they were the moneyline underdog.

Brewers vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (64.5%)

Brewers vs Cardinals Moneyline

• The Brewers vs Cardinals moneyline has Milwaukee as a -172 favorite, while St. Louis is a +144 underdog on the road.

Brewers vs Cardinals Spread

• The Brewers are hosting the Cardinals and are favored by 1.5 runs (+130 to cover) on the runline. St. Louis is -156 to cover.

Brewers vs Cardinals Over/Under

• Brewers versus Cardinals, on Sept. 25, has an over/under of 7.5, with the over being -142 and the under +116.

Bet on Milwaukee Brewers vs. St. Louis Cardinals on FanDuel today!

Brewers vs Cardinals Betting Trends

• The Brewers have won in 79, or 64.8%, of the 122 contests they have been named as odds-on favorites in this year.
• This year Milwaukee has won 23 of 32 games when listed as at least -172 on the moneyline.
• The Brewers' games have gone over the total in 69 of their 158 opportunities.
• The Brewers have an against the spread mark of 82-76-0 in 158 games with a line this season.
• The Cardinals have gone 46-54 in games they were the underdog on the moneyline (winning 46% of those games).
• St. Louis has a record of 8-11 when it has played as a moneyline underdog with odds of +144 or longer (42.1%).
• The Cardinals have played in 155 games with an over/under set, and have combined with their opponents to go over the total 71 times (71-77-7).
• The Cardinals have covered 53.5% of their games this season, going 83-72-0 ATS.

Brewers Player Leaders

• Brice Turang leads Milwaukee in slugging percentage (.444) thanks to 58 extra-base hits. He has a .267 batting average and an on-base percentage of .366.
• Among all qualified hitters, he is 45th in batting average, his on-base percentage ranks 16th, and he is 51st in slugging.
• Turang will look for his fourth straight game with a hit in this contest. In his last five games he is hitting .273 with a double, a home run and an RBI.
• William Contreras is batting .271 with 27 doubles, a triple, 18 home runs and 60 walks, while slugging .419 with an on-base percentage of .341.
• He is 39th in batting average, 53rd in on-base percentage and 72nd in slugging among qualified batters.
• Jake Bauers leads his team in OBP (.393) and total hits (125) this season.
• Jackson Chourio has been key for Milwaukee with 146 hits, an OBP of .345 plus a slugging percentage of .483.
• Chourio enters this matchup on a two-game hitting streak. During his last five outings he is hitting .200 with a home run, three walks and an RBI.

Cardinals Player Leaders

• Alec Burleson has put up a team-best .464 slugging percentage. He's batting .279 with an on-base percentage of .343.
• Including all the qualified hitters in the big leagues, his batting average is 25th, his on-base percentage is 51st, and he is 36th in slugging.
• Jordan Walker's 162 hits lead his team. He has a batting average of .271 while slugging .467 with an on-base percentage of .330.
• He is currently 39th in batting average, 69th in on-base percentage and 33rd in slugging percentage among all qualifying hitters.
• Ivan Herrera has put up an on-base percentage of .356, a team-high for the Cardinals.
• JJ Wetherholt is batting .246 with 15 doubles, 17 home runs and 64 walks.

Brewers vs Cardinals Head to Head

• 7/9/2026: 8-4 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/8/2026: 5-1 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 7/7/2026: 10-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/7/2026: 4-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 7/6/2026: 4-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 5/27/2026: 2-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/26/2026: 6-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 5/25/2026: 5-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 5/6/2026: 6-2 MIL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/4/2026: 6-3 STL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)

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