Brewers vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 7:11 p.m.

The Friday slate in MLB includes a matchup between the Milwaukee Brewers and the St. Louis Cardinals.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Brewers vs Cardinals Game Info

• Milwaukee Brewers (100-59) vs. St. Louis Cardinals (77-82)
• Date: Friday, September 25, 2026
• Time: 7:40 p.m. ET
• Venue: American Family Field -- Milwaukee, Wisconsin
• Coverage: Brewers.TV and Cardinals.TV

Brewers vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-188) | STL: (+158)
• Spread: MIL: -1.5 (+120) | STL: +1.5 (-144)
• Total: 7.5 -- Over: (-118) | Under: (-104)

Brewers vs Cardinals Probable Starting Pitchers

Probable Pitchers: Robert Gasser (Brewers) - 5-5, 4.01 ERA vs Michael McGreevy (Cardinals) - 7-9, 3.84 ERA

This contest's pitching matchup is set, as the Brewers will send Robert Gasser (5-5) to the mound, while Michael McGreevy (7-9) will take the ball for the Cardinals. Gasser's team is 9-10-0 against the spread in his starts this season. Gasser's team has a record of 9-4 this season when he starts and they are the favorite on the moneyline. The Cardinals have gone 17-13-0 ATS in McGreevy's 30 starts with a set spread. The Cardinals have been the moneyline underdog in 21 of McGreevy's starts this season, and they went 11-10 in those matchups.

Brewers vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (65.2%)

Brewers vs Cardinals Moneyline

• St. Louis is a +158 underdog on the moneyline, while Milwaukee is a -188 favorite at home.

Brewers vs Cardinals Spread

• The Cardinals are at +1.5 on the runline against the Brewers. The Cardinals are -144 to cover the spread, and the Brewers are +120.

Brewers vs Cardinals Over/Under

• A total of 7.5 runs has been set for the Brewers-Cardinals game on Sept. 25, with the over available at -118 and the under at -104.

Bet on Milwaukee Brewers vs. St. Louis Cardinals on FanDuel today!

Brewers vs Cardinals Betting Trends

• The Brewers have won in 79, or 64.8%, of the 122 contests they have been named as odds-on favorites in this year.
• Milwaukee has a record of 20-7 in contests when bookmakers favor them by -188 or more on the moneyline.
• The Brewers' games have gone over the total in 69 of their 158 opportunities.
• The Brewers are 82-76-0 against the spread in their 158 games that had a posted line this season.
• The Cardinals have won 46 of the 100 games they were the underdog on the moneyline this season (46%).
• St. Louis has a 5-9 record (winning only 35.7% of its games) when playing as a moneyline underdog of +158 or longer.
• The Cardinals have had an over/under set by oddsmakers 155 times, and have combined with opponents to go over the total in 71 of those games (71-77-7).
• The Cardinals have collected an 83-72-0 record ATS this season.

Brewers Player Leaders

• Brice Turang leads Milwaukee in slugging percentage (.444) thanks to 58 extra-base hits. He has a .267 batting average and an on-base percentage of .366.
• Among qualified hitters, he is 45th in batting average, his on-base percentage ranks 16th, and he is 51st in slugging.
• Turang hopes to build on a three-game hitting streak in this matchup. During his last five outings he is hitting .273 with a double, a home run and an RBI.
• William Contreras is batting .271 with 27 doubles, a triple, 18 home runs and 60 walks, while slugging .419 with an on-base percentage of .341.
• Among qualified batters, he is 39th in batting average, 53rd in on-base percentage and 72nd in slugging percentage.
• Jake Bauers leads his team in OBP (.393) and total hits (125) this season.
• Jackson Chourio has been key for Milwaukee with 146 hits, an OBP of .345 plus a slugging percentage of .483.
• Chourio takes a two-game hitting streak into this game. In his last five games he is hitting .200 with a home run, three walks and an RBI.

Cardinals Player Leaders

• Alec Burleson has put up a team-high .464 slugging percentage. He's batting .279 with an on-base percentage of .343.
• Including all qualified players, he ranks 25th in batting average, while his on-base percentage ranks 51st and he is 36th in slugging.
• Jordan Walker paces his team with 162 hits. He has a batting average of .271 while slugging .467 with an on-base percentage of .330.
• His batting average is 39th among all qualified players, his on-base percentage is 70th, and he is 33rd in slugging.
• Ivan Herrera has accumulated a team-high .356 on-base percentage.
• JJ Wetherholt has 15 doubles, 17 home runs and 64 walks while batting .246.

Brewers vs Cardinals Head to Head

• 7/9/2026: 8-4 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/8/2026: 5-1 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 7/7/2026: 10-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/7/2026: 4-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 7/6/2026: 4-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 5/27/2026: 2-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/26/2026: 6-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 5/25/2026: 5-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 5/6/2026: 6-2 MIL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/4/2026: 6-3 STL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)

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