Orioles vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 6:11 p.m.

The Baltimore Orioles versus the Washington Nationals is on the MLB schedule for Tuesday.

We've got you covered, in terms of the vital info about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Orioles vs Nationals Game Info

• Baltimore Orioles (9-12) vs. Washington Nationals (9-13)
• Date: Tuesday, April 22, 2025
• Time: 6:45 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN and MASN2

Orioles vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-136) | WSH: (+116)
• Spread: BAL: -1.5 (+112) | WSH: +1.5 (-134)
• Total: 9 -- Over: (-105) | Under: (-115)

Orioles vs Nationals Probable Starting Pitchers

Probable Pitchers: Dean Kremer (Orioles) - 2-2, 6.41 ERA vs Mitchell Parker (Nationals) - 2-1, 1.85 ERA

The Orioles will call on Dean Kremer (2-2) versus the Nationals and Mitchell Parker (2-1). Kremer and his team are 2-2-0 ATS this season when he starts. Kremer's team is 1-1 this season when he starts and they're favored on the moneyline. When Parker starts, the Nationals are 3-1-0 against the spread. The Nationals are 2-1 in Parker's three starts this season that they were the moneyline underdog.

Orioles vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (59%)

Orioles vs Nationals Moneyline

• Baltimore is a -136 favorite on the moneyline, while Washington is a +116 underdog at home.

Orioles vs Nationals Spread

• The Nationals are +1.5 on the run line against the Orioles. The Nationals are -134 to cover, and the Orioles are +112.

Orioles vs Nationals Over/Under

• An over/under of 9 has been set for Orioles-Nationals on April 22, with the over being -105 and the under -115.

Bet on Baltimore Orioles vs. Washington Nationals on FanDuel today!

Orioles vs Nationals Betting Trends

• The Orioles have won in five, or 41.7%, of the 12 contests they have been named as odds-on favorites in this year.
• This season Baltimore has come away with a win one time in five chances when named as a favorite of at least -136 on the moneyline.
• The Orioles' games have gone over the total in 14 of their 21 opportunities.
• The Orioles are 8-13-0 against the spread in their 21 games that had a posted line this season.
• The Nationals have won seven of the 17 games they were the underdog on the moneyline this season (41.2%).
• Washington has a 4-9 record (winning only 30.8% of its games) when it has played as a moneyline underdog of +116 or longer.
• The Nationals have played in 22 games with an over/under set, and have combined with opponents to go over the total 12 times (12-10-0).
• The Nationals have covered 45.5% of their games this season, going 10-12-0 against the spread.

Orioles Player Leaders

• Cedric Mullins leads Baltimore in OBP (.429), slugging percentage (.627) and total hits (19) this season. He has a .284 batting average.
• He is 50th in batting average, fifth in on-base percentage, and seventh in slugging among all qualified hitters in the majors.
• Mullins hopes to build on a three-game hitting streak in this matchup. During his last five outings he is batting .235 with a double, two home runs, five walks and two RBI.
• Adley Rutschman is hitting .208 with two doubles, four home runs and 10 walks. He's slugging .390 with an on-base percentage of .299.
• He ranks 131st in batting average, 113th in on-base percentage and 92nd in slugging in the major leagues.
• Ryan O'Hearn is batting .296 with a .519 slugging percentage and six RBI this year.
• Heston Kjerstad has been key for Baltimore with 12 hits, an OBP of .300 plus a slugging percentage of .500.

Nationals Player Leaders

• James Wood is leading the Nationals with 19 hits. He's batting .232 and slugging .524 with an on-base percentage of .337.
• Including all the qualified hitters in MLB, his batting average is 99th, his on-base percentage is 76th, and he is 27th in slugging.
• Keibert Ruiz is batting .306 with two doubles, two home runs and four walks. He's slugging .417 with an on-base percentage of .359.
• He is currently 26th in batting average, 49th in on-base percentage and 83rd in slugging percentage among all qualifying batters.
• Nate Lowe has an on-base percentage of .375 and a slugging percentage of .474. Both lead the Nationals.
• Alex Call is batting .293 with two doubles, a triple and 10 walks.

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