NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 15

The Week 15 NFL slate features several top-tier games, including a matchup between the Buffalo Bills and the Detroit Lions.

If you're seeking additional betting information for Week 15 in the NFL, we've got you covered with odds for all the important matchups.

49ers vs. Rams

Matthew Stafford, who ranks fifth-best in the league in passing yards, will aim to lead the charge for the Los Angeles Rams (7-6) on Dec. 12 at 8:15 p.m. ET, when they visit the San Francisco 49ers (6-7) and their third-best pass D (182.6 passing yards allowed per game).

• Matchup: Los Angeles Rams at San Francisco 49ers
• Projected Favorite: 49ers (60.31% win probability)
• Spread: San Francisco (-3)
• Total: 48.5 -- Over: (-105) | Under: (-115)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on San Francisco vs. Los Angeles with FanDuel Sportsbook.

Titans vs. Bengals

Star quarterback Joe Burrow and the Cincinnati Bengals meet the Tennessee Titans on Sunday at 1 p.m. ET at Nissan Stadium.

• Matchup: Cincinnati Bengals at Tennessee Titans
• Projected Favorite: Bengals (53.67% win probability)
• Spread: Cincinnati (-5.5)
• Total: 46.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Tennessee vs. Cincinnati with FanDuel Sportsbook.

Giants vs. Ravens

One of the top running backs in football will be on display when Derrick Henry and the Baltimore Ravens visit the New York Giants on Sunday, December 15, 2024.

• Matchup: Baltimore Ravens at New York Giants
• Projected Favorite: Ravens (78.39% win probability)
• Spread: Baltimore (-16.5)
• Total: 43.5 -- Over: (-108) | Under: (-112)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New York vs. Baltimore with FanDuel Sportsbook.

Browns vs. Chiefs

On Sunday at 1 p.m. ET, two outstanding pass-catchers will be on display when Travis Kelce and the Kansas City Chiefs visit Jerry Jeudy and the Cleveland Browns.

• Matchup: Kansas City Chiefs at Cleveland Browns
• Projected Favorite: Chiefs (66.39% win probability)
• Spread: Kansas City (-4.5)
• Total: 41.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Cleveland vs. Kansas City with FanDuel Sportsbook.

Texans vs. Dolphins

When the Houston Texans (8-5) and the Miami Dolphins (6-7) square off on Sunday, Dec. 15 at 1 p.m. ET, they will both be aiming to stay on track after winning their last tilt. The Texans won 23-20 against the Jaguars, and the Dolphins are coming off a 32-26 victory over the Jets.

• Matchup: Miami Dolphins at Houston Texans
• Projected Favorite: Texans (64.27% win probability)
• Spread: Houston (-2.5)
• Total: 46.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Houston vs. Miami with FanDuel Sportsbook.

Jaguars vs. Jets

One of the top pass-catchers in football will be on display when Brian Thomas Jr. and the Jacksonville Jaguars host the New York Jets on Sunday, December 15, 2024.

• Matchup: New York Jets at Jacksonville Jaguars
• Projected Favorite: Jets (53.12% win probability)
• Spread: New York (-3.5)
• Total: 40.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Jacksonville vs. New York with FanDuel Sportsbook.

Saints vs. Commanders

On Sunday at 1 p.m. ET, a pair of excellent pass-catchers will be featured when Terry McLaurin and the Washington Commanders visit Alvin Kamara and the New Orleans Saints.

• Matchup: Washington Commanders at New Orleans Saints
• Projected Favorite: Commanders (67.75% win probability)
• Spread: Washington (-7.5)
• Total: 43.5 -- Over: (-120) | Under: (-102)
• Time: 1 p.m. ET
• Channel: FOX

Bet on New Orleans vs. Washington with FanDuel Sportsbook.

Panthers vs. Cowboys

One of the best pass-catchers in football will be featured when CeeDee Lamb and the Dallas Cowboys visit the Carolina Panthers on Sunday, December 15, 2024.

• Matchup: Dallas Cowboys at Carolina Panthers
• Projected Favorite: Panthers (56.00% win probability)
• Spread: Carolina (-2.5)
• Total: 42.5 -- Over: (-104) | Under: (-118)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Carolina vs. Dallas with FanDuel Sportsbook.

Lions vs. Bills

Two of the best offensive performers in football will be on display when running back Jahmyr Gibbs and the Detroit Lions host QB Josh Allen and the Buffalo Bills on Sunday, December 15, 2024.

• Matchup: Buffalo Bills at Detroit Lions
• Projected Favorite: Lions (62.64% win probability)
• Spread: Detroit (-2.5)
• Total: 54.5 -- Over: (-110) | Under: (-110)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Detroit vs. Buffalo with FanDuel Sportsbook.

Eagles vs. Steelers

Saquon Barkley, who ranks first in the NFL in rushing yards, will try to lead the charge for the Philadelphia Eagles (11-2) on Dec. 15 at 4:25 p.m. ET, when they host the Pittsburgh Steelers (10-3) and their fourth-best run defense (91.5 rushing yards allowed per game).

• Matchup: Pittsburgh Steelers at Philadelphia Eagles
• Projected Favorite: Eagles (70.15% win probability)
• Spread: Philadelphia (-5.5)
• Total: 42.5 -- Over: (-115) | Under: (-105)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Philadelphia vs. Pittsburgh with FanDuel Sportsbook.

Broncos vs. Colts

The Denver Broncos (8-5) are slated to collide with the Indianapolis Colts (6-7) at Empower Field at Mile High on Sunday, Dec. 15 at 4:25 p.m. ET. Both teams won their previous tilt, as the Broncos defeated the Browns 41-32, and the Colts won 25-24 against the Patriots.

• Matchup: Indianapolis Colts at Denver Broncos
• Projected Favorite: Broncos (67.08% win probability)
• Spread: Denver (-3.5)
• Total: 43.5 -- Over: (-110) | Under: (-110)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Denver vs. Indianapolis with FanDuel Sportsbook.

Chargers vs. Buccaneers

At SoFi Stadium on Sunday, the Los Angeles Chargers face the Tampa Bay Buccaneers.

• Matchup: Tampa Bay Buccaneers at Los Angeles Chargers
• Projected Favorite: Chargers (52.35% win probability)
• Spread: Los Angeles (-3)
• Total: 45.5 -- Over: (-115) | Under: (-105)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Los Angeles vs. Tampa Bay with FanDuel Sportsbook.

Cardinals vs. Patriots

The Arizona Cardinals (6-7), who were defeated by the Seahawks in their last tilt, host the New England Patriots (3-10) at State Farm Stadium on Dec. 15 at 4:25 p.m. ET. The Patriots lost to the Colts in their last game.

• Matchup: New England Patriots at Arizona Cardinals
• Projected Favorite: Cardinals (72.67% win probability)
• Spread: Arizona (-6.5)
• Total: 46.5 -- Over: (-104) | Under: (-118)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Arizona vs. New England with FanDuel Sportsbook.

Seahawks vs. Packers

When the Green Bay Packers (9-4) and the Seattle Seahawks (8-5) meet on Sunday, Dec. 15 at 8:20 p.m. ET, the Packers will be attempting to rebound from a loss to the Lions, and the Seahawks will be looking to follow up their recent victory over the Cardinals with another win.

• Matchup: Green Bay Packers at Seattle Seahawks
• Projected Favorite: Packers (51.69% win probability)
• Spread: Green Bay (-2.5)
• Total: 47.5 -- Over: (-118) | Under: (-104)
• Time: 8:20 p.m. ET
• Channel: NBC

Bet on Seattle vs. Green Bay with FanDuel Sportsbook.

Vikings vs. Bears

One of the best pass-catchers in football will be on show when Justin Jefferson and the Minnesota Vikings host the Chicago Bears on Monday, December 16, 2024.

• Matchup: Chicago Bears at Minnesota Vikings
• Projected Favorite: Vikings (83.77% win probability)
• Spread: Minnesota (-7)
• Total: 44.5 -- Over: (-104) | Under: (-118)
• Time: 8 p.m. ET
• Channel: ABC

Bet on Minnesota vs. Chicago with FanDuel Sportsbook.

Raiders vs. Falcons

The Atlanta Falcons (6-7) and the Las Vegas Raiders (2-11), who both lost their last contest, will meet at 8:30 p.m. ET on Monday, Dec. 16. In their previous games, the Falcons lost 42-21 to the Vikings, and the Raiders were taken down by the Buccaneers 28-13.

• Matchup: Atlanta Falcons at Las Vegas Raiders
• Projected Favorite: Falcons (57.66% win probability)
• Spread: Atlanta (-5.5)
• Total: 44.5 -- Over: (-110) | Under: (-110)
• Time: 8:30 p.m. ET
• Channel: ESPN

Bet on Las Vegas vs. Atlanta with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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