Marlins vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for July 22

Odds updated as of 6:12 p.m.

The MLB's Tuesday schedule includes the Miami Marlins taking on the San Diego Padres.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Marlins vs Padres Game Info

• Miami Marlins (46-53) vs. San Diego Padres (55-45)
• Date: Tuesday, July 22, 2025
• Time: 6:40 p.m. ET
• Venue: loanDepot park -- Miami, Florida
• Coverage: FDSFL and SDPA

Marlins vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIA: (-132) | SD: (+112)
• Spread: MIA: -1.5 (+164) | SD: +1.5 (-200)
• Total: 8 -- Over: (-112) | Under: (-108)

Marlins vs Padres Probable Starting Pitchers

Probable Pitchers: Edward Cabrera (Marlins) - 3-4, 3.61 ERA vs Stephen Kolek (Padres) - 3-4, 4.24 ERA

The Marlins will give the nod to Edward Cabrera (3-4, 3.61 ERA), who is eyeing win No. 4 on the season, and the Padres will counter with Stephen Kolek (3-4, 4.24 ERA). Cabrera's team is 12-4-0 against the spread this season in his starts. Cabrera's team lost his only start as a favorite this season. The Padres have gone 7-5-0 against the spread when Kolek starts. The Padres have been the underdog on the moneyline in five of Kolek's starts this season, and they went 1-4 in those matchups.

Marlins vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (50.9%)

Marlins vs Padres Moneyline

• Miami is the favorite, -132 on the moneyline, while San Diego is a +112 underdog on the road.

Marlins vs Padres Spread

• The Marlins are 1.5-run home favorites on the runline against the Padres. The Marlins are +164 to cover, and the Padres are -200.

Marlins vs Padres Over/Under

• The over/under for Marlins-Padres on July 22 is 8. The over is -112, and the under is -108.

Bet on Miami Marlins vs. San Diego Padres on FanDuel today!

Marlins vs Padres Betting Trends

• The Marlins have won in three of the 10 contests they have been named as odds-on favorites in this year.
• Miami has a record of 1-6 when favored by -132 or more this year.
• The Marlins and their opponents have gone over the total this season in 45 of their 95 opportunities.
• The Marlins have an against the spread record of 56-39-0 in 95 games with a line this season.
• The Padres have won 22 of the 46 games they were the underdog on the moneyline this season (47.8%).
• San Diego has a 17-18 record (winning 48.6% of its games) when playing as a moneyline underdog of +112 or longer.
• The Padres have had an over/under set by bookmakers 98 times, and have combined with opponents to go over the total in 41 of those games (41-54-3).
• The Padres have a 54-44-0 record against the spread this season (covering 55.1% of the time).

Marlins Player Leaders

• Kyle Stowers leads Miami in OBP (.370) and total hits (94) this season. He's batting .295 batting average while slugging .564.
• Among qualified hitters in baseball, his batting average ranks eighth, his on-base percentage ranks 19th, and he is sixth in slugging.
• Otto Lopez has 11 doubles, 11 home runs and 32 walks. He's batting .251 and slugging .392 with an on-base percentage of .324.
• He is 96th in batting average, 86th in on-base percentage and 113th in slugging among qualified batters.
• Lopez heads into this game looking to extend his five-game hit streak. In his last five games he is batting .300 with two doubles, a home run, three walks and six RBIs.
• Xavier Edwards has an OPS of .712, fueled by an OBP of .355 and a team-best slugging percentage of .357 this season.
• Edwards brings a six-game hitting streak into this matchup. In his last 10 outings he is batting .333 with five doubles, a triple, a home run, a walk and seven RBIs.
• Agustin Ramirez has 14 home runs, 44 RBI and a batting average of .241 this season.

Padres Player Leaders

• Manny Machado has accumulated 109 hits with a .487 slugging percentage, both team-best stats for the Padres. He's batting .285 and with an on-base percentage of .347.
• Including all qualifying hitters, he ranks 23rd in batting average, while his on-base percentage is 51st and he is 29th in slugging.
• Fernando Tatis Jr. has a .365 OBP to lead his team. He has a batting average of .265 while slugging .443.
• Including all qualifying hitters, his batting average places him 68th, his on-base percentage ranks 26th, and he is 66th in slugging.
• Luis Arraez is hitting .283 with 17 doubles, four triples, five home runs and 19 walks.
• Xander Bogaerts is batting .268 with 21 doubles, six home runs and 43 walks.

Marlins vs Padres Head to Head

• 7/21/2025: 2-1 SD (Favorite: Marlins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/28/2025: 10-8 MIA (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/27/2025: 8-6 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/26/2025: 4-3 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/11/2024: 7-6 MIA (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 8/10/2024: 9-8 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 8/9/2024: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/29/2024: 9-1 MIA (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 5/28/2024: 4-0 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/27/2024: 2-1 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)

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