Iowa vs Michigan State Prediction, Odds, Picks, Best Bets for Week 13 2025

In college football action on Saturday, the Iowa Hawkeyes take on the Michigan State Spartans.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

Iowa vs Michigan State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Iowa: (-1149) | Michigan State: (+730)
• Spread: Iowa: -17.5 (-102) | Michigan State: +17.5 (-120)
• Total: 42.5 -- Over: (-110) | Under: (-110)

Iowa vs Michigan State Betting Trends

• Against the spread, Iowa is 8-2-0 this season.
• Iowa has won once ATS (1-1) as a 17.5-point or higher favorite this season.
• This year, four of Iowa's 10 games have gone over the point total.
• Michigan State's record against the spread in 2025 is 5-5-0.
• Michigan State has covered every time (2-0) as a 17.5-point or greater underdog this year.
• There have been six Michigan State games (out of 10) that hit the over this season.

Iowa vs Michigan State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Hawkeyes win (87.9%)

Iowa vs Michigan State Point Spread

Iowa is favored by 17.5 points versus Michigan State. Iowa is -102 to cover the spread, while Michigan State is -120.

Iowa vs Michigan State Over/Under

The over/under for the Iowa versus Michigan State game on Nov. 22 has been set at 42.5, with -110 odds on the over and -110 odds on the under.

Iowa vs Michigan State Moneyline

Looking at the moneyline for Iowa-Michigan State, Iowa is the favorite at -1149, and Michigan State is +730.

Iowa vs. Michigan State Points Insights

Iowa vs. Michigan State Game Info

• Game day: Saturday, November 22, 2025
• Game time: 3:30 p.m. ET
• TV channel: Fox Sports 1
• Location: Iowa City, Iowa
• Stadium: Kinnick Stadium

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Check out even more in-depth Iowa vs. Michigan State analysis on FanDuel Research.