Iowa State vs Iowa Prediction, Odds, Picks, Best Bets for Week 2 2025

College football's Saturday slate includes the Iowa State Cyclones facing the Iowa Hawkeyes.

We've got you covered, in terms of the most important information regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Iowa State vs Iowa Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Iowa State: (-162) | Iowa: (+134)
• Spread: Iowa State: -3.5 (-106) | Iowa: +3.5 (-114)
• Total: 42.5 -- Over: (-110) | Under: (-110)

Iowa State vs Iowa Betting Trends

• Iowa State hasn't lost a game against the spread this season.
• Iowa State has covered every time (1-0) as a 3.5-point favorite or greater this year.
• One of two Iowa State games have gone over the point total this year.
• Iowa has not won a game against the spread this year.
• Iowa and its opponent have yet to hit the over this year.

Iowa State vs Iowa Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Hawkeyes win (51.4%)

Iowa State vs Iowa Point Spread

Iowa is an underdog by 3.5 points against Iowa State. Iowa is -114 to cover the spread, and Iowa State is -106.

Iowa State vs Iowa Over/Under

A total of 42.5 points has been set for the Iowa State-Iowa game on Sept. 6, with the over available at -110 and the under at -110.

Iowa State vs Iowa Moneyline

Iowa is a +134 underdog on the moneyline, while Iowa State is a -162 favorite.

Iowa State vs. Iowa Points Insights

• The Cyclones had an average implied point total of 29.0 last season, which is 6.0 points higher than their implied total in Saturday's game (23).
• The average implied point total last season for the Hawkeyes (23.9) is 3.9 more points than the team's implied total in this matchup (20).

Iowa State vs. Iowa Game Info

• Game day: Saturday, September 6, 2025
• Game time: 12 p.m. ET
• TV channel: FOX
• Location: Ames, Iowa
• Stadium: Jack Trice Stadium

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