Indiana vs Iowa Prediction, Odds, Picks, Best Bets for Week 5 2025

College football's Saturday schedule includes the Indiana Hoosiers taking on the Iowa Hawkeyes.

Get the latest NCAA football odds ahead of this game on FanDuel Sportsbook.

Indiana vs Iowa Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Indiana: (-319) | Iowa: (+255)
• Spread: Indiana: -9.5 (-105) | Iowa: +9.5 (-115)
• Total: 47.5 -- Over: (-108) | Under: (-112)

Indiana vs Iowa Betting Trends

• Indiana's record against the spread is 3-1-0.
• As at least a 9.5-point favorite, Indiana has two wins ATS (2-1).
• Indiana has played four games this season, and three of them have gone over the total.
• Iowa's record against the spread in 2025 is 3-1-0.
• Iowa has played two games (out of four) which finished over the total this season.

Indiana vs Iowa Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Hoosiers win (77.1%)

Indiana vs Iowa Point Spread

Iowa is listed as an underdog by 9.5 points (-115 odds), and Indiana, the favorite, is -105 to cover.

Indiana vs Iowa Over/Under

The Indiana-Iowa game on Sept. 27 has been given an over/under of 47.5 points. The over is -108 and the under is -112.

Indiana vs Iowa Moneyline

Indiana is a -319 favorite on the moneyline, while Iowa is a +255 underdog.

Indiana vs. Iowa Points Insights

Indiana vs. Iowa Game Info

• Game day: Saturday, September 27, 2025
• Game time: 3:30 p.m. ET
• TV channel: Peacock
• Location: Iowa City, Iowa
• Stadium: Kinnick Stadium

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Check out even more in-depth Indiana vs. Iowa analysis on FanDuel Research.