Guardians vs Rockies Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 21

Odds updated as of 5:12 a.m.

MLB action on Friday includes the Cleveland Guardians facing the Colorado Rockies.

We've got you covered, in terms of the most important information regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Rockies Game Info

• Cleveland Guardians (62-66) vs. Colorado Rockies (50-77)
• Date: Friday, August 21, 2026
• Time: 8:40 p.m. ET
• Venue: Coors Field -- Denver, Colorado
• Coverage: Rockies.TV and CleGuardians.TV

Guardians vs Rockies Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-158) | COL: (+134)
• Spread: CLE: -1.5 (-110) | COL: +1.5 (-110)
• Total: 10.5 -- Over: (-122) | Under: (+100)

Guardians vs Rockies Probable Starting Pitchers

Probable Pitchers: Joey Cantillo (Guardians) - 9-7, 3.80 ERA vs Tanner Gordon (Rockies) - 0-3, 5.55 ERA

The Guardians will give the nod to Joey Cantillo (9-7, 3.80 ERA), who is eyeing win No. 10 on the season, and the Rockies will counter with Tanner Gordon (0-3, 5.55 ERA). Cantillo and his team have a record of 16-10-0 against the spread when he starts. Cantillo's team is 7-5 this season when he starts and they are the moneyline favorite. The Rockies are 2-3-0 against the spread when Gordon starts. The Rockies have been the underdog on the moneyline in five of Gordon's starts this season, and they went 2-3 in those matchups.

Guardians vs Rockies Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (53.6%)

Guardians vs Rockies Moneyline

• Cleveland is the favorite, -158 on the moneyline, while Colorado is a +134 underdog despite being at home.

Guardians vs Rockies Spread

• The Rockies are +1.5 on the run line against the Guardians. The Rockies are -110 to cover, and the Guardians are -110.

Guardians vs Rockies Over/Under

• The over/under for the Guardians versus Rockies contest on Aug. 21 has been set at 10.5, with -122 odds on the over and +100 odds on the under.

Bet on Cleveland Guardians vs. Colorado Rockies on FanDuel today!

Guardians vs Rockies Betting Trends

• The Guardians have been chosen as favorites in 70 games this year and have walked away with the win 33 times (47.1%) in those games.
• This year Cleveland has won seven of 12 games when listed as at least -158 on the moneyline.
• The Guardians and their opponents have hit the over in 60 of their 122 games with a total set by oddsmakers this season.
• The Guardians have posted a record of 58-64-0 against the spread this season.
• The Rockies have compiled a 47-73 record in games they were the underdog on the moneyline (winning 39.2% of those games).
• When it has played as a moneyline underdog with odds of +134 or longer, Colorado has gone 23-54 (29.9%).
• The Rockies have had an over/under set by oddsmakers 124 times, and have combined with opponents to go over the total in 61 of those games (61-60-3).
• The Rockies have a 66-58-0 record ATS this season.

Guardians Player Leaders

• Chase DeLauter leads Cleveland with 115 hits and a team-best slugging percentage of .442. He's batting .285 with an on-base percentage of .358.
• Among all qualified batters in baseball, he ranks 19th in batting average, 35th in on-base percentage, and 53rd in slugging.
• Jose Ramirez is batting .239 with 20 doubles, 10 home runs and 54 walks. He's slugging .382 with an on-base percentage of .340.
• Among qualified hitters, his batting average places him 104th, his on-base percentage 60th, and his slugging percentage 114th.
• Steven Kwan has 108 hits this season and a team-best OBP of .372.
• Brayan Rocchio is batting .251 with a .314 OBP and 52 RBI for Cleveland this season.

Rockies Player Leaders

• Jake McCarthy is hitting .295 with 26 doubles, seven triples, 13 home runs and 22 walks. He's slugging .490 with an on-base percentage of .334.
• Including all the qualifying players in MLB, he ranks ninth in batting average, 69th in on-base percentage and 21st in slugging percentage.
• TJ Rumfield's .372 on-base percentage and .447 slugging percentage both pace his team. He has a batting average of .292.
• Including all qualified hitters, he is 12th in batting average, 14th in on-base percentage and 50th in slugging percentage.
• Willi Castro is hitting .264 with 18 doubles, a triple, 14 home runs and 37 walks.
• Mickey Moniak is hitting .266 with 15 doubles, four triples, 20 home runs and 18 walks.

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