Diamondbacks vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 21

Odds updated as of 9:12 p.m.

The MLB slate on Friday includes the Arizona Diamondbacks taking on the Cincinnati Reds.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Diamondbacks vs Reds Game Info

• Arizona Diamondbacks (67-61) vs. Cincinnati Reds (61-67)
• Date: Friday, August 21, 2026
• Time: 9:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: Dbacks.TV and Reds.TV

Diamondbacks vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-142) | CIN: (+132)
• Spread: ARI: -1.5 (+134) | CIN: +1.5 (-162)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Diamondbacks vs Reds Probable Starting Pitchers

Probable Pitchers: Eduardo Rodríguez (Diamondbacks) - 12-4, 2.71 ERA vs Nick Lodolo (Reds) - 3-2, 4.52 ERA

The probable starters are Eduardo Rodriguez (12-4) for the Diamondbacks and Nick Lodolo (3-2) for the Reds. Rodriguez and his team have a record of 16-9-0 against the spread when he starts. When Rodriguez starts a game and his team is the favorite on the moneyline, they have a record of 8-3. When Lodolo starts, the Reds are 6-8-0 against the spread. The Reds have a 4-5 record in Lodolo's nine starts this season when they were the underdog on the moneyline.

Diamondbacks vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (63.4%)

Diamondbacks vs Reds Moneyline

• The Diamondbacks vs Reds moneyline has Arizona as a -142 favorite, while Cincinnati is a +132 underdog on the road.

Diamondbacks vs Reds Spread

• The Diamondbacks are 1.5-run home favorites on the runline against the Reds. The Diamondbacks are +134 to cover, and the Reds are -162.

Diamondbacks vs Reds Over/Under

• A total of 8.5 runs has been set for the Diamondbacks-Reds game on Aug. 21, with the over available at -105 and the under at -115.

Bet on Arizona Diamondbacks vs. Cincinnati Reds on FanDuel today!

Diamondbacks vs Reds Betting Trends

• The Diamondbacks have been chosen as favorites in 51 games this year and have walked away with the win 30 times (58.8%) in those games.
• This season Arizona has been victorious 10 times in 19 chances when named as a favorite of at least -142 on the moneyline.
• The Diamondbacks and their opponents have hit the over in 55 of their 127 games with a total set by oddsmakers this season.
• The Diamondbacks are 68-59-0 against the spread in their 127 games with a line set by sportsbooks this season.
• The Reds have won 47% of the games this season they were the underdog on the moneyline (39-44).
• Cincinnati has a 7-11 record (winning only 38.9% of its games) when it has played as a moneyline underdog of +132 or longer.
• The Reds have had an over/under set by oddsmakers 125 times, and have combined with opponents to go over the total in 66 of those games (66-57-2).
• The Reds have put together a 66-59-0 record against the spread this season.

Diamondbacks Player Leaders

• Corbin Carroll leads Arizona in total hits (114) this season while batting .246 with 59 extra-base hits. He has an on-base percentage of .346 and a slugging percentage of .484.
• Among all qualified hitters, he ranks 87th in batting average, his on-base percentage ranks 52nd, and he is 26th in slugging.
• Geraldo Perdomo is batting .244 with 17 doubles, six triples, nine home runs and 75 walks, while slugging .371 with an on-base percentage of .355.
• Among all qualifying hitters, he is 90th in batting average, 38th in on-base percentage and 119th in slugging percentage.
• Gabriel Moreno leads Arizona in OBP (.385) this season, fueled by 109 hits.
• Moreno takes a 13-game hitting streak into this game. In his last 10 games he is hitting .341 with six doubles, a triple, two home runs, four walks and 12 RBIs.
• Nolan Arenado has 20 home runs, 63 RBI and a batting average of .243 this season.

Reds Player Leaders

• Sal Stewart has racked up 126 hits with a .474 slugging percentage, both team-high numbers for the Reds. He's batting .259 and with an on-base percentage of .335.
• Including all qualifying hitters in MLB, his batting average places him 68th, his on-base percentage is 66th, and he is 31st in slugging.
• Stewart heads into this matchup on a five-game hitting streak. In his last five games he is hitting .263 with a double, a home run, two walks and five RBIs.
• Elly De La Cruz has a .343 OBP to pace his team. He has a batting average of .259 while slugging .467.
• Including all qualified hitters, his batting average places him 68th, his on-base percentage is 56th, and he is 38th in slugging.
• JJ Bleday is batting .219 with 13 doubles, a triple, 20 home runs and 59 walks.
• Matt McLain has 17 doubles, 12 home runs and 43 walks while batting .200.

Diamondbacks vs Reds Head to Head

• 6/14/2026: 5-3 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 10, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/13/2026: 2-1 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 6/12/2026: 5-2 ARI (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/24/2025: 6-1 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 8/23/2025: 10-1 ARI (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/22/2025: 6-5 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/8/2025: 4-2 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/7/2025: 13-1 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/15/2024: 2-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 5/14/2024: 6-2 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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