Diamondbacks vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 21

Odds updated as of 5:12 a.m.

MLB action on Friday includes the Arizona Diamondbacks taking on the Cincinnati Reds.

We've got you covered, in terms of the vital information regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Diamondbacks vs Reds Game Info

• Arizona Diamondbacks (67-61) vs. Cincinnati Reds (61-67)
• Date: Friday, August 21, 2026
• Time: 9:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: Dbacks.TV and Reds.TV

Diamondbacks vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-154) | CIN: (+130)
• Spread: ARI: -1.5 (+136) | CIN: +1.5 (-164)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Diamondbacks vs Reds Probable Starting Pitchers

Probable Pitchers: Eduardo Rodríguez (Diamondbacks) - 12-4, 2.71 ERA vs Nick Lodolo (Reds) - 3-2, 4.52 ERA

This contest's pitching matchup is set, as the Diamondbacks will send Eduardo Rodriguez (12-4) to the mound, while Nick Lodolo (3-2) will get the nod for the Reds. Rodríguez's team is 16-9-0 against the spread in his starts this season. When Rodriguez starts a game and his team is the favorite on the moneyline, they have a record of 8-3. The Reds have gone 6-8-0 ATS in Lodolo's 14 starts that had a set spread. The Reds have a 4-5 record in Lodolo's nine starts this season when they were the moneyline underdog.

Diamondbacks vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (63%)

Diamondbacks vs Reds Moneyline

• Looking at the moneyline for Reds-Diamondbacks, Cincinnati is the underdog at +130, and Arizona is -154 playing at home.

Diamondbacks vs Reds Spread

• The Diamondbacks are 1.5-run home favorites on the runline against the Reds. The Diamondbacks are +136 to cover, and the Reds are -164.

Diamondbacks vs Reds Over/Under

• Diamondbacks versus Reds on Aug. 21 has an over/under of 8.5 runs, with the odds on the over -105 and the under set at -115.

Bet on Arizona Diamondbacks vs. Cincinnati Reds on FanDuel today!

Diamondbacks vs Reds Betting Trends

• The Diamondbacks have won in 30, or 58.8%, of the 51 contests they have been named as odds-on favorites in this year.
• This season Arizona has come away with a win six times in 10 chances when named as a favorite of at least -154 on the moneyline.
• The Diamondbacks and their opponents have gone over the total this season in 55 of their 127 opportunities.
• In 127 games with a line this season, the Diamondbacks have a mark of 68-59-0 against the spread.
• The Reds have been the underdog on the moneyline 83 total times this season. They've finished 39-44 in those games.
• Cincinnati is 7-13 (winning only 35% of its games) when it has played as a moneyline underdog of +130 or longer.
• The Reds have played in 125 games with a set over/under, and have combined with their opponents to go over the total 66 times (66-57-2).
• The Reds have a 66-59-0 record against the spread this season (covering 52.8% of the time).

Diamondbacks Player Leaders

• Corbin Carroll leads Arizona in total hits (114) this season while batting .246 with 59 extra-base hits. He has an on-base percentage of .346 and a slugging percentage of .484.
• Among qualifying batters in baseball, his batting average ranks 87th, his on-base percentage ranks 52nd, and he is 26th in slugging.
• Geraldo Perdomo is hitting .244 with 17 doubles, six triples, nine home runs and 75 walks. He's slugging .371 with an on-base percentage of .355.
• He ranks 90th in batting average, 38th in on-base percentage and 119th in slugging in the major leagues.
• Gabriel Moreno leads Arizona with an OBP of .385 this season while batting .307 with 46 walks and 55 runs scored.
• Moreno brings a 13-game hitting streak into this game. During his last 10 outings he is batting .341 with six doubles, a triple, two home runs, four walks and 12 RBIs.
• Nolan Arenado has been key for Arizona with 100 hits, an OBP of .322 plus a slugging percentage of .443.

Reds Player Leaders

• Sal Stewart has a team-high slugging percentage (.474) while pacing the Reds in hits (126). He's batting .259 and with an on-base percentage of .335.
• He is 67th in batting average, 66th in on-base percentage and 31st in slugging percentage among all qualified batters in the big leagues.
• Stewart hopes to build on a five-game hitting streak in this matchup. In his last five games he is hitting .263 with a double, a home run, two walks and five RBIs.
• Elly De La Cruz paces his team with a .343 on-base percentage. He has a batting average of .259 while slugging .467.
• Including all qualifying hitters, he ranks 67th in batting average, 56th in on-base percentage and 38th in slugging percentage.
• JJ Bleday is hitting .219 with 13 doubles, a triple, 20 home runs and 59 walks.
• Matt McLain is batting .200 with 17 doubles, 12 home runs and 43 walks.

Diamondbacks vs Reds Head to Head

• 6/14/2026: 5-3 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 10, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/13/2026: 2-1 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 6/12/2026: 5-2 ARI (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/24/2025: 6-1 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 8/23/2025: 10-1 ARI (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/22/2025: 6-5 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/8/2025: 4-2 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/7/2025: 13-1 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/15/2024: 2-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 5/14/2024: 6-2 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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