White Sox vs Mets Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 21

Odds updated as of 7:12 p.m.

Friday's slate in the MLB includes a matchup between the Chicago White Sox and the New York Mets.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

White Sox vs Mets Game Info

• Chicago White Sox (66-61) vs. New York Mets (58-70)
• Date: Friday, August 21, 2026
• Time: 7:40 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and WPIX

White Sox vs Mets Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHW: (-126) | NYM: (+116)
• Spread: CHW: -1.5 (+158) | NYM: +1.5 (-192)
• Total: 7.5 -- Over: (-124) | Under: (+102)

White Sox vs Mets Probable Starting Pitchers

Probable Pitchers: Sean Burke (White Sox) - 7-6, 3.15 ERA vs Sean Manaea (Mets) - 4-5, 4.22 ERA

This contest's pitching matchup is set, as the White Sox will send Sean Burke (7-6) to the mound, while Sean Manaea (4-5) will take the ball for the Mets. Burke's team is 10-11-0 against the spread this season in his starts. Burke's team has won 66.7% of his starts when they are favored on the moneyline (4-2). The Mets are 6-6-0 against the spread when Manaea starts. The Mets are 3-5 in Manaea's eight starts this season that they were the moneyline underdog.

White Sox vs Mets Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: White Sox win (51.9%)

White Sox vs Mets Moneyline

• Chicago is the favorite, -126 on the moneyline, while New York is a +116 underdog on the road.

White Sox vs Mets Spread

• The White Sox are favored by 1.5 runs at home versus the Mets. The White Sox are +158 to cover the spread, while the Mets are -192.

White Sox vs Mets Over/Under

• The over/under for White Sox-Mets on Aug. 21 is 7.5. The over is -124, and the under is +102.

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White Sox vs Mets Betting Trends

• The White Sox have been victorious in 14, or 58.3%, of the 24 contests they have been chosen as favorites in this season.
• This season Chicago has come away with a win seven times in 12 chances when named as a favorite of at least -126 on the moneyline.
• The White Sox and their opponents have gone over the total this season in 68 of their 124 opportunities.
• The White Sox are 73-51-0 against the spread in their 124 games that had a posted line this season.
• The Mets have won 17 of the 53 games they were listed as the moneyline underdog this season (32.1%).
• When it has played as a moneyline underdog with odds of +116 or longer, New York has a 6-18 record (winning just 25% of its games).
• The Mets have had an over/under set by bookmakers 124 times, and have combined with opponents to go over the total in 54 of those games (54-63-7).
• The Mets have put together a 57-67-0 record against the spread this season.

White Sox Player Leaders

• Miguel Vargas is batting .240 with 29 doubles, a triple, 28 home runs and 72 walks. He has an on-base percentage of .347 while slugging .487.
• Among qualified batters in baseball, he ranks 101st in batting average, 50th in on-base percentage, and 24th in slugging.
• Munetaka Murakami has 75 hits, which ranks first among Chicago batters this season. He's batting .227 with 42 extra-base hits. He's also slugging .530 with an on-base percentage of .363.
• Among qualifying batters, he is 119th in batting average, 26th in on-base percentage and 11th in slugging percentage.
• Chase Meidroth has hit 12 homers with a team-high .406 SLG this season.
• Sam Antonacci has 99 hits this season and a team-best OBP of .364.

Mets Player Leaders

• Bo Bichette has a .388 slugging percentage, which leads the Mets. He's batting .266 with an on-base percentage of .314.
• Including all qualifying players, he ranks 50th in batting average, while his on-base percentage is 102nd and he is 107th in slugging.
• Carson Benge leads his team with 125 hits and a .334 OBP. He has a batting average of .272 while slugging .418.
• Including all qualified hitters, his batting average places him 38th, his on-base percentage is 69th, and he is 83rd in slugging.
• Francisco Lindor has seven doubles, four triples, 12 home runs and 34 walks while batting .239.
• Marcus Semien has 10 doubles, a triple, 14 home runs and 32 walks while hitting .209.

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