Guardians vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for April 25

Odds updated as of 12:12 p.m.

The Cleveland Guardians are among the MLB squads busy on Saturday, up against the Boston Red Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this game.

Guardians vs Red Sox Game Info

• Cleveland Guardians (14-10) vs. Boston Red Sox (14-13)
• Date: Saturday, April 26, 2025
• Time: 1:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: Apple TV+

Guardians vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-110) | BOS: (-106)
• Spread: CLE: +1.5 (-182) | BOS: -1.5 (+150)
• Total: 8 -- Over: (-105) | Under: (-115)

Guardians vs Red Sox Probable Starting Pitchers

Probable Pitchers: Ben Lively (Guardians) - 1-2, 3.86 ERA vs Tanner Houck (Red Sox) - 0-2, 7.66 ERA

The Guardians will give the nod to Ben Lively (1-2) against the Red Sox and Tanner Houck (0-2). When Lively starts, his team is 2-3-0 against the spread this season. Lively's team won his only start as a favorite this season. The Red Sox have gone 1-4-0 ATS in Houck's five starts that had a set spread. The Red Sox were the underdog on the moneyline for two Houck starts this season -- they split the games.

Guardians vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (50.3%)

Guardians vs Red Sox Moneyline

• Looking at the moneyline for Guardians-Red Sox, Cleveland is the favorite at -110, and Boston is -106 playing on the road.

Guardians vs Red Sox Spread

• The Red Sox are 1.5-run favorites against the spread for this matchup with the Guardians. The Red Sox are +150 to cover, while the Guardians are -182 to cover as a 1.5-run underdog on the runline.

Guardians vs Red Sox Over/Under

• Guardians versus Red Sox on April 26 has an over/under of 8 runs, with the odds on the over -105 and the under set at -115.

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Guardians vs Red Sox Betting Trends

• The Guardians have come away with eight wins in the 10 contests they have been listed as the favorites in this season.
• This season Cleveland has been victorious eight times in 10 chances when named as a favorite of at least -110 on the moneyline.
• The Guardians' games have gone over the total in 12 of their 24 opportunities.
• The Guardians have an against the spread mark of 11-13-0 in 24 games with a line this season.
• The Red Sox have gone 3-4 in games they were the underdog on the moneyline (winning 42.9% of those games).
• Boston has a 3-4 record (winning 42.9% of its games) when playing as a moneyline underdog of -106 or longer.
• The Red Sox have had an over/under set by bookmakers 27 times, and have combined with opponents to go over the total in 11 of those games (11-14-2).
• The Red Sox have gone 13-14-0 against the spread this season.

Guardians Player Leaders

• Steven Kwan has an OPS of .889, fueled by an OBP of .394 to go with a slugging percentage of .495. He has a .337 batting average, as well.
• Among all qualifying batters, he ranks sixth in batting average, his on-base percentage ranks 17th, and he is 32nd in slugging.
• Kwan has recorded a base hit in seven games in a row. During his last 10 games he is hitting .350 with two doubles, two home runs, four walks and six RBI.
• Jose Ramirez is batting .265 with four doubles, five home runs and nine walks, while slugging .494 with an on-base percentage of .330.
• He is 61st in batting average, 76th in on-base percentage and 33rd in slugging in the majors.
• Kyle Manzardo leads Cleveland with 16 hits. He is batting .219 this season and 11 of his hits have gone for extra bases.
• Manzardo has recorded a hit in six games in a row. During his last 10 games he is batting .212 with two doubles, three home runs, five walks and seven RBI.
• Gabriel Arias is batting .270 with a .321 OBP and 10 RBI for Cleveland this season.

Red Sox Player Leaders

• Alexander David Bregman has accumulated a team-high OBP (.393) and slugging percentage (.563), and paces the Red Sox in hits (33, while batting .320).
• Including all qualifying hitters in the big leagues, his batting average puts him 11th, his on-base percentage ranks 18th, and he is 14th in slugging.
• Bregman takes a five-game hitting streak into this matchup. In his last five games he is batting .444 with three doubles, a home run, three walks and five RBI.
• Wilyer Abreu is hitting .271 with six doubles, four home runs and 16 walks. He's slugging .482 with an on-base percentage of .386.
• He is currently 54th in batting average, 26th in on-base percentage and 39th in slugging percentage among all qualifying hitters.
• Jarren Duran is batting .250 with seven doubles, two triples, a home run and eight walks.
• Trevor Story is hitting .297 with two doubles, five home runs and four walks.

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