Guardians vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 12:12 p.m.

The MLB schedule on Wednesday includes the Cleveland Guardians facing the Houston Astros.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding this game.

Guardians vs Astros Game Info

• Cleveland Guardians (14-11) vs. Houston Astros (9-16)
• Date: Wednesday, April 22, 2026
• Time: 1:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and SCHN

Guardians vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-152) | HOU: (+128)
• Spread: CLE: -1.5 (+136) | HOU: +1.5 (-164)
• Total: 8 -- Over: (-114) | Under: (-106)

Guardians vs Astros Probable Starting Pitchers

Probable Pitchers: Tanner Bibee (Guardians) - 0-2, 4.81 ERA vs Peter Lambert (Astros) - 0-1, 7.20 ERA

The probable starters are Tanner Bibee (0-2) for the Guardians and Peter Lambert (0-1) for the Astros. Bibee and his team have a record of 1-4-0 against the spread when he starts. Bibee's team is 0-2 this season when he starts and they're favored on the moneyline. Lambert has started just one game with a set spread, which the Astros failed to cover. The Astros have yet to be named a moneyline underdog when Lambert starts this season.

Guardians vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (50.4%)

Guardians vs Astros Moneyline

• The Guardians vs Astros moneyline has Cleveland as a -152 favorite, while Houston is a +128 underdog on the road.

Guardians vs Astros Spread

• The Astros are +1.5 on the run line against the Guardians. The Astros are -164 to cover, and the Guardians are +136.

Guardians vs Astros Over/Under

• A total of 8 runs has been set for the Guardians-Astros game on April 22, with the over available at -114 and the under at -106.

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Guardians vs Astros Betting Trends

• The Guardians have been victorious in six of the 10 contests they have been chosen as favorites in this season.
• Cleveland has played as a favorite of -152 or more just one time this year and came away with a win in that game.
• Contests with the Guardians have gone over the total set by sportsbooks in 13 of 25 chances this season.
• The Guardians are 15-10-0 against the spread in their 25 games that had a posted line this season.
• The Astros have won 37.5% of the games this season they were the moneyline underdog (3-5).
• Houston has played in three games as a moneyline underdog with odds of +128 or longer without claiming a victory.
• The Astros have played in 25 games with an over/under set, and have combined with their opponents to go over the total 18 times (18-7-0).
• The Astros have collected a 9-16-0 record ATS this season (covering only 36% of the time).

Guardians Player Leaders

• Jose Ramirez leads Cleveland with a slugging percentage of .489, fueled by 11 extra-base hits. He has a .233 batting average and an on-base percentage of .367.
• Among qualified hitters in baseball, his batting average ranks 109th, his on-base percentage ranks 41st, and he is 38th in slugging.
• Ramirez will look for his fourth straight game with a hit in this matchup. During his last five outings he is batting .286 with a double, two home runs, eight walks and two RBIs.
• Chase DeLauter leads Cleveland in total hits (17) this season while batting .221 with 11 extra-base hits. He's slugging .506 with an on-base percentage of .322.
• His batting average is 129th among qualified players, his on-base percentage 106th, and his slugging percentage 31st.
• Brayan Rocchio leads the Guardians with an OPS of .830. He has a slash line of .284/.384/.446 this season.
• Rocchio enters this game with eight games in a row with at least one hit. In his last 10 games he is hitting .382 with two doubles, two home runs, three walks and nine RBIs.
• Steven Kwan has an OPS of .596, fueled by an OBP of .308 and a team-best slugging percentage of .287 this season.

Astros Player Leaders

• Yordan Alvarez has put up a team-high OBP (.456) and slugging percentage (.747), while leading the Astros in hits (30, while batting .330).
• Including all qualified hitters, he ranks fourth in batting average, while his on-base percentage ranks second and he is second in slugging.
• Alvarez takes an eight-game hitting streak into this game. In his last 10 outings he is batting .293 with four doubles, four home runs, five walks and 10 RBIs.
• Christian Walker is hitting .261 with seven doubles, five home runs and 12 walks. He's slugging .511 with an on-base percentage of .353.
• He is 68th in batting average, 59th in on-base percentage and 30th in slugging percentage in the big leagues.
• Jose Altuve has six doubles, three home runs and 15 walks while hitting .266.
• Carlos Correa is batting .286 with five doubles, a home run and 12 walks.

Guardians vs Astros Head to Head

• 4/21/2026: 8-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 4/20/2026: 9-2 HOU (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/9/2025: 4-2 CLE (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 7/8/2025: 10-6 CLE (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 7/7/2025: 7-5 CLE (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/8/2025: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/7/2025: 5-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/6/2025: 4-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/28/2024: 4-3 HOU (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/27/2024: 5-2 HOU (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)

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